RESUMO

Children with acute lymphocytic leukemia were examined for evidence of intracranial calcifications with roentgenograms of the skull and computerized tomography. Of 39 children in their initial complete remission, ten were found to have subcortical cerebral calcifications. Significant associations were found between the presence of cerebral calcifications and systemic treatment with large cumulative doses of methotrexate.

Assuntos

Encefalopatias/induzido quimicamente , Calcinose/induzido quimicamente , Citarabina/efeitos adversos , Leucemia Linfoide/tratamento farmacológico , Metotrexato/efeitos adversos , Adolescente , Encefalopatias/diagnóstico por imagem , Calcinose/diagnóstico por imagem , Citarabina/uso terapêutico , Humanos , Metotrexato/uso terapêutico , Radiografia , Remissão Espontânea