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1.
Front Fungal Biol ; 2: 768648, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-37744129

RESUMO

Symbiotic strains of fungi in the genus Trichoderma affect growth and pathogen resistance of many plant species, but the interaction is not known in molecular detail. Here we describe the transcriptomic response of two cultivars of the crop Chenopodium quinoa to axenic co-cultivation with Trichoderma harzianum BOL-12 and Trichoderma afroharzianum T22. The response of C. quinoa roots to BOL-12 and T22 in the early phases of interaction was studied by RNA sequencing and RT-qPCR verification. Interaction with the two fungal strains induced partially overlapping gene expression responses. Comparing the two plant genotypes, a broad spectrum of putative quinoa defense genes were found activated in the cultivar Kurmi but not in the Real cultivar. In cultivar Kurmi, relatively small effects were observed for classical pathogen response pathways but instead a C. quinoa-specific clade of germin-like genes were activated. Germin-like genes were found to be more rapidly induced in cultivar Kurmi as compared to Real. The same germin-like genes were found to also be upregulated systemically in the leaves. No strong correlation was observed between any of the known hormone-mediated defense response pathways and any of the quinoa-Trichoderma interactions. The differences in responses are relevant for the capabilities of applying Trichoderma agents for crop protection of different cultivars of C. quinoa.

2.
Trends Mol Med ; 20(9): 519-28, 2014 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25164066

RESUMO

Therapies that selectively target cancer cells for death have been the center of intense research recently. One potential therapy may involve apoptin proteins, which are able to induce apoptosis in cancer cells leaving normal cells unharmed. Apoptin was originally discovered in the Chicken anemia virus (CAV); however, human gyroviruses (HGyV) have recently been found that also harbor apoptin-like proteins. Although the cancer cell specific activity of these apoptins appears to be well conserved, the precise functions and mechanisms of action are yet to be fully elucidated. Strategies for both delivering apoptin to treat tumors and disseminating the protein inside the tumor body are now being developed, and have shown promise in preclinical animal studies.


Assuntos
Antineoplásicos/farmacologia , Proteínas do Capsídeo/farmacologia , Sistemas de Liberação de Medicamentos/métodos , Animais , Antineoplásicos/administração & dosagem , Apoptose/efeitos dos fármacos , Proteínas do Capsídeo/fisiologia , Morte Celular/efeitos dos fármacos , Vírus da Anemia da Galinha/química , Gyrovirus/química , Humanos , Proteínas Virais/isolamento & purificação , Proteínas Virais/farmacologia
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