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Med Oral Patol Oral Cir Bucal ; 17(5): e745-50, 2012 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-22549684

RESUMO

OBJECTIVE: The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC). STUDY DESIGN: We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies. RESULTS: We found p53 immunoexpression in 71.4% OLP cases and 68.7% OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy. CONCLUSIONS: Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease.


Assuntos
Carcinoma de Células Escamosas/imunologia , Líquen Plano Bucal/imunologia , Neoplasias Bucais/imunologia , Proteínas Proto-Oncogênicas c-bcl-2/imunologia , Proteína Supressora de Tumor p53/imunologia , Adulto , Idoso , Carcinoma de Células Escamosas/metabolismo , Feminino , Humanos , Líquen Plano Bucal/metabolismo , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/metabolismo , Proteínas Proto-Oncogênicas c-bcl-2/biossíntese , Proteína Supressora de Tumor p53/biossíntese , Adulto Jovem
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