Assuntos
Testes de Carcinogenicidade/história , Alcatrão/toxicidade , Neoplasias/etiologia , Nicotiana/toxicidade , Fumar/efeitos adversos , Animais , Argentina , Benzopirenos/toxicidade , Alcatrão/química , Feminino , História do Século XX , Humanos , Masculino , Neoplasias/mortalidade , Coelhos , Pesquisa/história , Nicotiana/químicaRESUMO
The experimentations effectuated to transmit leprosy, show that the human leprosy-bacillus, inoculated on inferior monkeys develops a tissue with granulations which has the clinical and histological characters of human leproma.The frotis of the nodes, as well as the histological preparations present numerous bacillus which resist the acids; they are ordered in bundles, and have the properties of the leprosy-bacillus. The giant-cells are very parasitic by the bacillus which is observed sometimes in a quantity of 30-40, occupying with preference the vacuole of these enormous cells.The lepromas produce themselves after a pariod of incubation which varies from 30 to days , reaching their highest development at about the 60th day.The receptibility of these animals varies with the race. Thus I attribute a very great importance to the terrain, as the injuries of the African monkey (plate 3) have been much more intensive and durable than in other monkeys, and it happened something what happens with other absolutely human conditions, for instance syphilis.On another inferior African monkey (Erythrocebus Pata) we could not observe any injury, in spite of various inoculations effectuated.There is no doubt that it would have been very interesting to make experimentations with anthropomorphous apes, but unfortunately, their high price did not allow them. In the same manner we observed that the development of these injuries depends on the original human leproma. The acute form with many bacillus and its proper treatment has produced the best lepromas.The reinoculation of these products of human lepromas on three monkeys which had developped 4 months ago lepromas with the characteristics that the period of incubation was shorter, 30 to only 15 days, and the evolution of the new leproma has been more intensive.When the development of the leproma begins after the priod of incubation, the general state of the animal changes compeltely. One observes an intensive anorexia with consecutive growing lean.The injuries developped on these monkeys can be considered to be a localized infection of experimetnal leprosy, but the development is far away to reproduce the human illness with its characteristics of a generalized process and progressive evolution.In these experimetnal lepromas must be seen the reaction of the tissue in presence of the bacillus named, which with its specific secretions originates the formation of a tissue with granulations and the formation.....