RESUMO
PURPOSE: The main objective of this study is to describe the prevalence, degree and risk of corneal involvement, and visual impact in a pediatric population with blepharokeratoconjunctivitis (BKC). METHODS: Retrospective, observational, case-control study. Clinical records of patients ≤16 years old with BKC seen between 2006 and 2012 were reviewed. The prevalence and relative risk of corneal involvement was evaluated between patients with and without corneal affection through a univariate and multivariate analysis with logistic regression. Visual acuity at presentation and at last follow-up visit was also analyzed. RESULTS: One hundred and fourteen children with BKC, with a male-to-female ratio of 1 : 1 and a mean age at diagnosis of 9.13 years. The mean follow-up time was 26.4 (±25) months. Corneal involvement was present in 39.5% of patients, varying from superficial punctate keratitis to perforation. Corneal changes were not seen in children under 4 years old. The risk of corneal affection was greater in patients with photophobia, hordeolum, female gender and asymmetric disease (OR of 2.69, 11.6, 2.35 and 2.77, respectively). The mean best-corrected visual acuity at presentation was 0.20 (corneal affected group), compared to 0.11 (unaffected group; P=0.02). CONCLUSIONS: Our study showed an older age at time of diagnosis and a worse visual outcome in patients with BKC and corneal disease compared with previous reports. Early diagnosis and detection of risk factors for corneal involvement, as well as adequate treatment, is mandatory to prevent serious long-term visual repercussions in children with BKC.
Assuntos
Blefarite/epidemiologia , Doenças da Córnea/epidemiologia , Ceratoconjuntivite/epidemiologia , Acuidade Visual/fisiologia , Blefarite/fisiopatologia , Estudos de Casos e Controles , Criança , Doença Crônica , Doenças da Córnea/fisiopatologia , Diagnóstico Precoce , Feminino , Seguimentos , Humanos , Ceratoconjuntivite/fisiopatologia , Masculino , México/epidemiologia , Prevalência , Estudos Retrospectivos , Fatores de RiscoRESUMO
Amphipterygium adstringens is a plant widely used in Mexican traditional medicine for its known anti-inflammatory and antiulcer properties. In this work, we evaluated the in vitro antimicrobial and antiproliferative activities of the methanolic extract of A. adstringens against oral pathogens such as Streptococcus mutans, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Candida albicans, and Candida dubliniensis, using microdilution (MIC) and agar diffusion methods (MBC), and the antiproliferative activity evaluating total growth inhibition (TGI) by staining the protein content with sulforhodamine B (SRB), using nine human cancer cell lines. Crude extract (CE) of A. adstringens showed some degree of activity against one or more of the strains with a MIC from 0.125 mg/mL to 63 mg/mL and MBC from 1.6 to 6.3 mg/mL and cytotoxic activity, particularly against NCI-ADR/RES, an ovarian cell line expressing multiple resistance drugs phenotype. The CE is a complex mixture of possible multitarget metabolites that could be responsible for both antimicrobial and antiproliferative activities, and further investigation is required to elucidate the identity of active compounds. Nevertheless the CE itself is useful in the development of new antimicrobial treatment based on natural products to prevent oral diseases and as alternative natural source for cancer treatment and prevention.
Assuntos
DNA de Neoplasias/análise , Neoplasias/diagnóstico , Biópsia por Agulha , Feminino , Citometria de Fluxo/métodos , Neoplasias dos Genitais Femininos/química , Neoplasias dos Genitais Femininos/diagnóstico , Neoplasias dos Genitais Femininos/patologia , Humanos , Masculino , Neoplasias/química , Neoplasias/patologia , Prognóstico , Coloração e Rotulagem/métodos , Neoplasias Urológicas/química , Neoplasias Urológicas/diagnóstico , Neoplasias Urológicas/patologiaRESUMO
Se presentan cuatro casos de sindrome de West (espasmos mioclonicos generalizados, detencion del desarrollo psicomotor e hipsarritmia), considerados resistentes al tratamiento tradicional (ACTH, nitrazepan, clonazepan, etc.); en los que se empleo fiebre alta (piretoterapia), producida con vacuna TBA, (tifica y paratifica), para el control del mismo. Dentro de los ocho dias subsiguientes al tratamiento con piretoterapia, las condiciones clinicas de estos ninos se reportaron con una disminucion progresiva de los espasmos mioclonicos generalizados y mejoria de su estado mental y desarrollo neurologico. Los electroencefalogramas de control senalaron desaparicion del trazo de hipsarritmia. Despues del analisis de los casos y su correlacion electroclinica, se sugiere que la piretoterapia sea un procedimiento util en esta entidad de epilepsia tan invalidante
Assuntos
Humanos , Hipertermia Induzida , Espasmos InfantisRESUMO
Se comunica la observacion de dos hermanos portadores de una enfermedad neurologica degenerativa con caracter autosomico recesivo; los datos clinicos predominantes en ambos se expresan por diplejia espastica, amiotrofia y retroceso de funciones intelectuales; en los dos casos se encontro ausencia de arginasa en eritrocitos y aumento de arginemia en suero. Los hallazgos clinicos en estos ninos, muestran dos fases de la evolucion de la enfermedad y los de laboratorio, confirman arginemia, senalando que se trata de una variedad de diplejia espastica familiar y arginemia y se suman a los diez casos previamente descritos en la literatura mundial
Assuntos
Pré-Escolar , Criança , Humanos , Masculino , Feminino , Erros Inatos do Metabolismo dos Aminoácidos , Arginase , Paralisia CerebralRESUMO
Se exponen las caracteristicas etiologicas, clinicas y evolutivas de 20 ninos con bronquiectasia
Assuntos
Bronquiectasia , Asma , Sarampo , Pneumonia , Tuberculose PulmonarRESUMO
En los ultimos anos se han estudiado en el Instituto Nacional de Neurologia y Neurocirugia de Mexico un numero progresivamente mayor de pacientes con esclerosis multiple bien definida. Tradicionalmente, Mexico ha sido considerado como una de las mas bajas areas de prevalencia de este padecimiento. Nuestras observaciones senalan un posible aumento de la esclerosis multiple en la poblacion mexicana, aunque este dato debe tomarse con reservas. Se indica la necesidad de conducir un estudio epidemiologico multicentrico para establecer y estudiar esta probabilidad. Se discuten en el presente trabajo las caracteristicas clinicas y de laboratorio, asi como las explicaciones probables de este incremento de pacientes con esclerosis multiple atendidos en el Instituto Nacional de Neurologia y Neurocirugia de Mexico