RESUMO

Zanthoxylum chiloperone var. angustifolium root bark was studied with the aim of finding novel molecules able to overcome cancer stem cell chemoresistance. Purification of a methanol-soluble extract resulted in the isolation of a known pyranocoumarin, trans-avicennol (1). Compound 1 demonstrated antiproliferative activity on glioma-initiating cells, whereas it was inactive on human neural stem cells. trans-Avicennol (1) activated the MAPK/ERK pathway and was also evaluated for its ability to inhibit the enzyme indoleamine-2,3-dioxygenase.

Assuntos

Antineoplásicos Fitogênicos/isolamento & purificação , Antineoplásicos Fitogênicos/farmacologia , Cumarínicos/isolamento & purificação , Cumarínicos/farmacologia , Células-Tronco Neurais/efeitos dos fármacos , Pironas/isolamento & purificação , Pironas/farmacologia , Zanthoxylum/química , Animais , Antineoplásicos Fitogênicos/química , Cumarínicos/química , Humanos , Indolamina-Pirrol 2,3,-Dioxigenase/antagonistas & inibidores , Camundongos , Quinases de Proteína Quinase Ativadas por Mitógeno/efeitos dos fármacos , Estrutura Molecular , Paraguai , Casca de Planta/química , Pironas/química , Estereoisomerismo