Assuntos
Carcinoma de Células em Anel de Sinete/terapia , Neoplasias do Colo/terapia , Adulto , Idoso de 80 Anos ou mais , Antineoplásicos/uso terapêutico , Carcinoma de Células em Anel de Sinete/diagnóstico por imagem , Carcinoma de Células em Anel de Sinete/patologia , Neoplasias do Colo/diagnóstico por imagem , Neoplasias do Colo/patologia , Feminino , Humanos , Masculino , Cuidados Paliativos , Prognóstico , Recusa do Paciente ao TratamentoRESUMO
BACKGROUND/AIMS: Contradictory results regarding the optimal initial dose of levothyroxine in children with congenital hypothyroidism (CH) hamper the clinical management of these children during their early infancy. We explore the relationships between the initial dose of levothyroxine and endocrine control during the first 6 months and cognition at school age. SUBJECTS AND METHODS: Fifty children with CH, 14 boys (10+/-3.1 years) and 36 girls (9.7+/-2.6 years), at the Pediatric Endocrine Unit of the Hospital Gregorio Marañón in Madrid were studied. Neurocognitive evaluation was carried out exploring alertness and inhibitory control. The number of episodes of overtreatment during the first 6 months, the initial dose of levothyroxine, etiology and sex were the predictor variables. RESULTS: Inhibitory control was significantly lower in children with CH than in controls. An interaction with gender and etiology was obtained. Alertness had an inverse relationship with the number of episodes of overtreatment with no interaction with gender or etiology. CONCLUSION: Episodes of overtreatment and not the initial dose of levothyroxine are a risk factor for deficit in alertness whereas subtle inhibitory control deficit seems to be a permanent problem with the current therapeutic approach.
Assuntos
Hipotireoidismo Congênito/terapia , Função Executiva/efeitos dos fármacos , Terapia de Reposição Hormonal/métodos , Tiroxina/administração & dosagem , Criança , Hipotireoidismo Congênito/sangue , Hipotireoidismo Congênito/psicologia , Relação Dose-Resposta a Droga , Feminino , Terapia de Reposição Hormonal/efeitos adversos , Humanos , Lactente , Modelos Lineares , Masculino , Tireotropina/sangue , Tiroxina/sangueRESUMO
MATERIAL AND METHODS: Serum IgE levels and the relationship with some variables in 78 asthmatic children patients, (1 to 5), is reported. RESULTS SHOWED: 66% had more than one year of the evolution with the illness, 64% presented more than two asthma episodes per month arid 82% had required hospital care for their stability Laboratory results: 52 patients had higher concentration in IgE serum levels than normal limit (ranges: 8 to 12,000, median 687.27 Ul ml). From these patients, 92% had required hospital care; 96% they had more than 2 years of illness evolution and 72.96% they had a higher concentration of eosinophils. CONCLUSION: In this study, the results have allowed us to know characteristics of the patients with high serum IgE levels in our region. Also, the obtained data will allow us to base the design of further research.