RESUMO
The results of a study of markers of infection/immunity by hepatitis B virus in a community of the health area in "Cristobal Labra" polyclinics, City of Habana in 1995. The studied healthy adult population was not included in any vaccination strategy with hepatitis B vaccine. Two markers were studied: Hepatitis B surface antigen and its corresponding antibody (anti-HBs). HBsAg-positivity was 1.05% and anti-HBs positivity was 13.39%. Of anti-HBs-positive cases, 13.39% had titers from 10-50 UI/L and the rest (43.68%) had titers over 50 UI/L.
Assuntos
Anticorpos Anti-Hepatite B/sangue , Vírus da Hepatite B/imunologia , Hepatite B/imunologia , Adolescente , Adulto , Idoso , Cuba , Humanos , Pessoa de Meia-Idade , População UrbanaRESUMO
The usefulness of the whole sample taking in filter paper for the detection of anti-HAV IgM is described. 168 serum and filter paper samples were simultaneously compared. No alterations were observed in the specificity of the enzyme-linked immunosorbent assay for the catchment of IgM in the 52 samples of the control group or in the other 116 from patients with clinical suspicion of acute viral hepatitis. A sensitivity, specificity and coincidence of 100% was obtained on comparing the filter paper with the dilution 1:500 with the serum. The correlation established between the values of optical density of the positive results to anti-HAV IgM, the filter paper at dilution 1:500 and the serum was of 0.895. On applying this type of sample taking in a group of hospitalized patients, 100% of coindicence with clinical suspicion was attained. Besides, it was proved its usefulness for the diagnosis of a viral hepatitis outbreak. According to our results, it is recommended the introduction of this type of sample taking in the diagnosis of hepatitis A.