RESUMO

BACKGROUND: Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis. OBJECTIVE: The aim of this study was to determine the association of CYP1A1 and COMT polymorphisms with this disease. MATERIAL AND METHODS: A pilot case-control study was conducted with Mexican women. Ninety-one breast cancer patients and 94 healthy controls were selected. Epidemiological and clinical questionnaires were answered by all participants, and genotyping data were obtained. CYP1A1 3801 T>C (rs4646903), CYP1A1 4889 A>G (rs1048943) and COMT 1947 G>A (rs4680) polymorphisms were analyzed by PCR-RFLP. RESULTS: The results showed a high risk of breast cancer in women carrying the CYP1A1 (3801 T>C) m2/m2 genotype (OR=2.52; 95%CI=1.04-6.08). The risk was higher in postmenopausal women (OR=3.38; 95%CI=1.05-10.87). No association between COMT 1947 G>A (rs4680) or CYP1A1 4889 A>G (rs1048943) and breast cancer was found. CONCLUSIONS: This study suggests that the CYP1A1 (3801 T>C) m2/m2 genotype may contribute to breast cancer susceptibility in Mexican women.

Assuntos

Neoplasias da Mama/genética , Carcinoma Ductal de Mama/genética , Catecol O-Metiltransferase/genética , Citocromo P-450 CYP1A1/genética , Proteínas de Neoplasias/genética , Polimorfismo de Nucleotídeo Único , Adulto , Idoso , Neoplasias da Mama/enzimologia , Neoplasias da Mama/epidemiologia , Carcinoma Ductal de Mama/enzimologia , Carcinoma Ductal de Mama/epidemiologia , Catecol O-Metiltransferase/fisiologia , Anticoncepcionais Femininos/efeitos adversos , Citocromo P-450 CYP1A1/fisiologia , Estrogênios/metabolismo , Estrogênios/uso terapêutico , Feminino , Predisposição Genética para Doença , Genótipo , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Proteínas de Neoplasias/fisiologia , Neoplasias Hormônio-Dependentes/enzimologia , Neoplasias Hormônio-Dependentes/epidemiologia , Neoplasias Hormônio-Dependentes/genética , Projetos Piloto , Pós-Menopausa , História Reprodutiva , Risco , Fumar/epidemiologia