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1.
J Pediatr ; 166(5): 1313-1315.e1, 2015 May.
Artigo em Inglês | MEDLINE | ID: mdl-25748567

RESUMO

UNLABELLED: This prospective observational pilot study evaluated the aerosolized intranasal route for dexmedetomidine as a safe, effective, and efficient option for infant and pediatric sedation for computed tomography imaging. The mean time to sedation was 13.4 minutes, with excellent image quality, no failed sedations, or significant adverse events. TRIAL REGISTRATION: Registered with ClinicalTrials.gov: NCT01900405.


Assuntos
Sedação Consciente/métodos , Dexmedetomidina/administração & dosagem , Tomografia Computadorizada por Raios X , Administração Intranasal , Aerossóis , Pré-Escolar , Feminino , Hemodinâmica , Humanos , Hipnóticos e Sedativos/administração & dosagem , Lactente , Masculino , Projetos Piloto , Estudos Prospectivos
2.
J Pediatr ; 163(4): 1217-9, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23809050

RESUMO

This pilot study introduces the aerosolized route for midazolam as an option for infant and pediatric sedation for computed tomography imaging. This technique produced predictable and effective sedation for quality computed tomography imaging studies with minimal artifact and no significant adverse events.


Assuntos
Administração Intranasal , Anestésicos Intravenosos/administração & dosagem , Sedação Consciente/métodos , Midazolam/administração & dosagem , Tomografia Computadorizada por Raios X , Aerossóis , Peso Corporal , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Segurança do Paciente , Projetos Piloto
3.
J Pediatr ; 161(5): 927-32, 2012 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-22704249

RESUMO

OBJECTIVES: To describe the efficacy and outcome of dexmedetomidine (Dex) via the intramuscular (IM) route for sedation for electroencephalography (EEG). STUDY DESIGN: Quality assurance data and EEG studies were reviewed for consecutive patients who received IM Dex for EEGs between August 2007 and September 2009. Sleep spindles, delta waves, and beta activity were evaluated to determine the deepest stage of sleep achieved. RESULTS: One hundred seven consecutive children (age 0.2-17 years) between August 2007 and September 2009 received IM Dex (range 1.0-4.5 mcg/kg). The average time to achieve sedation was 15.5 minutes (range 3.0-55.0) with an average of 54.5 minutes to meet discharge criteria following EEG studies, which averaged 34.2 ± 22.6 minutes. The deepest stage of sleep recorded for each child was: awake (n = 1), stage N2 (n = 51), and stage N3 (n = 55). Excessive beta activity was seen in only 1 patient. Epileptiform activity was noted in 11 patients. Hemodynamic fluctuations in heart rate and blood pressure were noted, none of which required pharmacologic intervention. All EEGs were successfully completed. CONCLUSION: We describe Stage 3 sleep and preserved background activity in response to Dex. We present the IM route as a new method, which preserves background EEG activity to provide safe and effective sedation for EEG studies.


Assuntos
Sedação Profunda/métodos , Dexmedetomidina/administração & dosagem , Eletroencefalografia/métodos , Injeções Intramusculares/métodos , Adolescente , Pressão Sanguínea/efeitos dos fármacos , Criança , Pré-Escolar , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Hipnóticos e Sedativos/farmacologia , Lactente , Recém-Nascido , Masculino , Pediatria/métodos , Sono , Fases do Sono
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