RESUMO
BACKGROUND: Dermatophagoides pteronyssinus, Dermatophagoides siboney and Blomia tropicalis are the most important allergenic mites in Cuba. The aim of this study was to determine the degree of polysensitization and correlation of the skin prick test (SPT) reaction size to these mites in asthmatic patients. METHODS: A total of 232 adult patients with asthmatic symptoms caused by house dust and positive SPT to at least one mite were included. Standardized allergenic extracts were used in SPT. RESULTS: A total of 88.4% of patients were positive to D. siboney, 87.1% to D. pteronyssinus, and 68.1% to B. tropicalis. Sensitization to Dermatophagoides species was predominant, demonstrated by the fact that 31.9% of patients showed positive SPT to either D. siboney or D. pteronyssinus only, whereas only 5.6% was sensitized solely to B. tropicalis. Nevertheless, most patients (58.6%) were polysensitized to the 3 species. The mean wheal size produced by the different allergens in positive patients was similar (n.s. p > 0.05). Reaction size was strongly correlated (r = 0.71, p = 5.3 x 10-09) between D. siboney and D. pteronyssinus, whereas no significant correlation was found between D. pteronyssinus or D. siboney and B. tropicalis. CONCLUSIONS: The results of this study support the need to include the 3 allergens in diagnostic panels and for combined allergen-specific immunotherapy.
Assuntos
Alérgenos , Asma/etiologia , Dermatophagoides pteronyssinus/imunologia , Pyroglyphidae/imunologia , Sarcoptidae/imunologia , Testes Cutâneos , Adulto , Alérgenos/imunologia , Animais , Antígenos de Dermatophagoides/imunologia , Asma/epidemiologia , Asma/imunologia , Estudos Transversais , Cuba/epidemiologia , Poeira , Feminino , Humanos , Masculino , Prevalência , Especificidade da EspécieRESUMO
AIMS: The chronic urticaria and the angioedema affect to the population's wide sectors and up to now their cause is ignored. MATERIAL AND METHOD: They were studied during one year 50 mature patients with chronic urticaria coming from the ambulatory consultation of the service of alergología of the Hospital CQ Hermanos Ameijeiras. The diagnosis of chronic urticaria settled down clinically for observation of the lesions and for the time of its evolution that should exceed six weeks. It was included as group witness to 26 healthy individuals. RESULTS: They were high levels for the IgE seric in the patients' 70%; you even normal of IgA, IgG and IgM in the great majority of the cases. The determination of circulating immunocomplexs gave negative in 88% of the sick and only positive in 12%. The tests for cutirreacción with extracts alergénicos micóticos, in reading at the 48 hours, were not negative in a significant way, among the group of sick and in the group witness.