RESUMO
ANTECEDENTES: La obesidad se ha asociado con estado proinflamatorio de bajo grado que se ha relacionado con el desarrollo del cáncer en general incluyendo el hematológico. OBJETIVOS: El presente trabajo tiene el objetivo de identificar la asociación del diagnóstico de obesidad acorde al índice de masa corporal (IMC) con indicadores pronóstico de pacientes adultos con Leucemia Linfoblástica Aguda (LAL). PACIENTES Y MÉTODO: Se trata de un estudio observacional, retrospectivo que incluyó pacientes hospitalizados con diagnóstico de LAL de linaje de células B. Se estimó el IMC con base al peso y talla registrado al ingreso de los pacientes. Se determinó el riesgo de recaídas, recaídas a médula ósea y supervivencia. Se utilizó el método de Kaplan-Meier mediante el test log-Rank en el análisis estadístico. RESULTADOS: Se incluyeron 128 pacientes. El peso y el IMC no mostraron una asociación significativa con el riesgo de recaídas. La frecuencia de recaída a médula ósea fue del 43,8%. La obesidad no impactó con la supervivencia global (p = 0,640) ni en la supervivencia libre de enfermedad (p = 0,527). La presencia de obesidad no se comportó como una variable de riesgo de recaída (p = 0,873). El IMC con punto de corte de 30 kg/m2 no se comportó como un factor de riesgo de recaída (OR 1.078). Conclusión: La obesidad no es un factor de riesgo independiente para el pronóstico de los pacientes adultos portadores de Leucemia Linfoblástica Aguda de linaje B.
BACKGROUND: Obesity has been associated with a low-grade proinflammatory state, and it has been related to the development of cancer in general, including hematologic cancer. AIM: The present work aimed to identify the association of the diagnosis of obesity according to the body mass index (BMI) with prognostic factors of adult patients with Acute Lymphoblastic Leukemia (ALL). PATIENTS AND METHOD: This observational, retrospective study included hospitalized patients diagnosed with ALL of the B-cell lineages. BMI was estimated based on the weight and height registered on clinical records at the admission of the patients. The relapse risk and bone marrow relapse were determined, and the survival rate was measured. The statistical analysis included the Kaplan-Meier method using the log-Rank test. Results: This study included 128 clinical records of patients. Weight had no significant association with relapse risk. The frequency of bone marrow relapse was 43.8%. Obesity did not impact overall survival (p = 0.640) or disease-free survival (p = 0.527). The presence of obesity does not behave as a relapse risk variable (p = 0.873). BMI with a 30 kg/m2 cut-off point did not influence relapse risk (OR 1.078). CONCLUSION: Obesity is not an independent risk factor for the prognosis of adult patients with Acute Lymphoblastic Leukemia B-lineage.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Índice de Massa Corporal , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Leucemia-Linfoma Linfoblástico de Células Precursoras/mortalidade , Obesidade/complicações , Prognóstico , Recidiva , Estudos Retrospectivos , Fatores de Risco , Intervalo Livre de Doença , Estimativa de Kaplan-MeierRESUMO
BACKGROUND: Obesity has been associated with a low-grade proinflammatory state, and it has been related to the development of cancer in general, including hematologic cancer. AIM: The present work aimed to identify the association of the diagnosis of obesity according to the body mass index (BMI) with prognostic factors of adult patients with Acute Lymphoblastic Leukemia (ALL). PATIENTS AND METHOD: This observational, retrospective study included hospitalized patients diagnosed with ALL of the B-cell lineages. BMI was estimated based on the weight and height registered on clinical records at the admission of the patients. The relapse risk and bone marrow relapse were determined, and the survival rate was measured. The statistical analysis included the Kaplan-Meier method using the log-Rank test. RESULTS: This study included 128 clinical records of patients. Weight had no significant association with relapse risk. The frequency of bone marrow relapse was 43.8%. Obesity did not impact overall survival (p = 0.640) or disease-free survival (p = 0.527). The presence of obesity does not behave as a relapse risk variable (p = 0.873). BMI with a 30 kg/m2 cut-off point did not influence relapse risk (OR 1.078). CONCLUSION: Obesity is not an independent risk factor for the prognosis of adult patients with Acute Lymphoblastic Leukemia B-lineage.
Assuntos
Índice de Massa Corporal , Obesidade , Leucemia-Linfoma Linfoblástico de Células Precursoras , Humanos , Masculino , Estudos Retrospectivos , Feminino , Obesidade/complicações , Adulto , Leucemia-Linfoma Linfoblástico de Células Precursoras/mortalidade , Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações , Fatores de Risco , Pessoa de Meia-Idade , Adulto Jovem , Prognóstico , Adolescente , Recidiva , Idoso , Estimativa de Kaplan-Meier , Intervalo Livre de DoençaRESUMO
Formative intervention is a participatory methodology that supports organizational change by means of an interactive and systematic dialogue carried out by researchers and participants. In this process, the researchers contribute to expanding the conversational space in the organization by supporting participants in examining and reflecting on their own work practices, as well as in modeling, shaping, and experimenting with innovations. Drawing on transcripts of videotaped sessions, this study analyzes how change is discursively sustained by the researchers who conduct the meetings within a formative intervention in a Mexican hospital. The quantitative and qualitative analysis focuses on the collective pronoun "we" as a membership categorization device deployed by the researchers for rhetorical and pragmatical aims, such as questioning about the state of necessity for the intervention, engaging the participants, or introducing a proposal of innovation with the participants. Results show how group membership and social identity markers are used by researchers to support emerging forms of collaboration, involvement of participants and the creation of common ground during the intervention process. In terms of the practical implications of the study, an informed and strategic use of membership categorization devices used by the researcher can increase the effectiveness of their formative and expansive role.
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El concepto de Economía Creativa o Naranja es relativamente nuevo en el mundo, pero se tienen muchas esperanzas en sus efectos positivos. Colombia no es ajena a esta tendencia, razón por la cual lo está estudiando. El Rosario aporta a la investigación.
The concept of Creative Economy or Orange is relatively new in the world, but hopes are high for its positive effects. Colombia is no stranger to this trend, which is why it is studying it. El Rosario contributes to the investigation.
Assuntos
Humanos , Economia , PesquisaRESUMO
Resumen La Selva Baja Caducifolia (SBC) es de gran importancia por su biodiversidad. En el Istmo-Costa de Oaxaca, México, se encuentran áreas con SBC y distinta categoría de protección (legislación mexicana): (1) Área Natural Protegida (ANP), (2) Área Destinada Voluntariamente para la Conservación (ADVC) y (3) Área de Uso Común (ADUC). En cada una de ellas se analizó la estructura de vegetación leñosa, plantas con DAP ≥ 2.5 cm, muestreando 15 parcelas de 100 m2. La riqueza observada fue de 90 especies incluidas en 36 familias y corresponde al 80 % (Jackknife) y 85 % (ICE) de la esperada. El análisis de agrupamiento identificó dos grupos con 90 % de disimilitud: el primero (G1) incluyó a todas las parcelas muestreadas del ANP; y el segundo (G2) aglomeró las del ADVC y ADUC. Los índices de Shannon, dominancia de Simpson y diversidad verdadera de Jost para el G1 fueron H'= 2.43, D= 0.21 y qD= 11 y para el G2, H'= 2.76, D= 0.28 y qD= 15, sin diferencias entre grupos (P < 0.05). Las especies con Valor de Importancia Relativa más elevado, en ambos grupos, corresponden a vegetación secundaria. La densidad de especies del G1 fue de 1 829 ind/ha y en el G2 de 2 370 ind/ha. Los promedios de altura (6.8 m) y área basal (19.7 m2/ha) del G1 no variaron significativamente (P < 0.05) con los del G2 (7.9 m y 22.1 m2/ha). Las ADVC y ADUC, semejantes en composición y estructura, difieren del ANP. Se sugiere seguir monitoreando la SBC.
Abstract Tropical dry forest (TDF) is important due to its biodiversity. In the Isthmus-Coastal region of the state of Oaxaca, in Southeast Mexico, there are many areas of TDF with varying categories of legal protection (1) Protected Natural Areas (PNA), (2) Voluntarily Designated Conservation Areas (VDCA) and (3) Areas of Common Use (ACU). In each of these, tree vegetation structure was analysed, recording plants with a DBH ≥ 2.5 cm and sampling 15 plots of 100 m2. Observed richness was 90 species, belonging to 36 families and corresponding to 80 % (Jackknife) and 85 % (ICE) of expected richness. A cluster analysis identified two groups with 90 % dissimilitude: the first (G1) included all the sampled plots in the PNA; and the second (G2), grouped together those from the VDCA and the ACU. The Shannon, Simpson dominance and Jost true diversity indices for G1 were H'= 2.43, D= 0.21 and qD= 11 and for G2, H'= 2.76, D= 0.28 and qD= 15 respectively, with no differences between groups (P < 0.05). The species that presented the highest relative importance value (RIV) in both groups, corresponded to secondary vegetation. Species density of G1 was 1 829 ind/ha and 2 370 ind/ha for G2. Mean height (6.8 m) and basal area (19.7 m2/ha) of G1 did not vary significantly (P < 0.05) when compared to G2 (7.9 m y 22.1 m2/ha). The VDCA and ACU presented similar composition and structure, differing from the PNA. Continual monitoring of the TDF is suggested. Rev. Biol. Trop. 66(2): 863-879. Epub 2018 June 01.
Assuntos
Solo , Árvores/classificação , Agricultura Florestal/classificação , Espécies em Perigo de Extinção/estatística & dados numéricos , Conservação dos Recursos Naturais/estatística & dados numéricos , Áreas Protegidas/análise , Fenômenos Ecológicos e Ambientais , MéxicoRESUMO
Background: The aim of this paper was to determine the most common etiology of ocular evisceration in a tertiary-level hospital. Methods: Observational and retrospective study in the Ophthalmology Department from January 2013 to December 2016 at the Centro Médico Nacional Siglo XXI. Results: Of the 54 eviscerations, exogenous endophthalmitis was found 25.90%, ocular trauma 22.2%, painful blind eye 14.8%, perforated corneal ulcer and endogenous endophthalmitis both in 13% and perforated infectious corneal ulcers 11.1%; 70.4% were associated with systemic comorbidities and 79.6% were associated with ophthalmologic comorbidities. Conclusions: Exogenous endophthalmitis is the most frequent evisceration; the loss of an eyeball, has important social and labor impact, and economic for the Instituto Mexicano del Seguro Social.
Introducción: El objetivo de este trabajo fue describir la etiología más frecuente de evisceración ocular en un hospital de tercer nivel de atención. Métodos: Estudio observacional y retrospectivo en el servicio de Oftalmología del Hospital de Especialidades del CMN SXXI de enero del 2013 a diciembre del 2016. Resultados: De las 54 evisceraciones, se encontraron como causas principales: la endoftalmitis exógena (25.90%), el traumatismo ocular (22.2%), el ojo ciego doloroso (14.8%), la úlcera corneal perforada y la endoftalmitis endógena, ambas con 13%, así como las úlceras corneales perforadas infecciosas (11.1%); el 70.4% de estas causas estuvieron asociadas a comorbilidades sistémicas y el 79.6% a comorbilidades oftalmológicas. Conclusiones: Las endoftalmitis exógenas son las causas más frecuentes de evisceración; la pérdida de un globo ocular tiene importante repercusión social, laboral, y económico para el Instituto Mexicano del Seguro Social.
Assuntos
Oftalmopatias/cirurgia , Evisceração do Olho , Traumatismos Oculares/cirurgia , Oftalmopatias/epidemiologia , Traumatismos Oculares/epidemiologia , Humanos , México/epidemiologia , Estudos Retrospectivos , Centros de Atenção TerciáriaRESUMO
Objetivo: Determinar el efecto antibacteriano de tres cementos endodónticos (Super EBA, Ketac Endo y MTA) frente a tres especies bacterianas potencialmente patógenas de la pulpa y periápice radicular (Porphyromonas gingivalis, Streptococcus mutans y Enterococcus faecalis). Material y método: Las especies bacterianas fueron sembradas en 30 placas petri enriquecidas en sus propios medios; donde también se colocaron los respectivos cementos para luego en medios anaeróbicos ser expuestos en la incubadora a 37ºC y anotar el diámetro de los halos de inhibición a las 24, 48 y 168 horas como también las observaciones respectivas en las fichas de registro. Resultados: El efecto antibacteriano de los cementos estudiados se mantiene durante las 24 y 48 horas, mientras que para algunas bacterias se reduce levemente entre las 48 y 168 horas. Conclusiones: Los tres cementos presentaron efecto antibacteriano variable sobre las cepas estudiadas, siendo mayor el del Súper EBA, seguido por el Ketac Endo. El MTA tuvo el menor efecto antibacterial.
Objective: To determinate the antibacterial effect of three endodontics cements (Super EBA, Ketac Endo y MTA) on three potentially pathogenic bacterial species of the pulp and root (Porphyromonas gingivalis, Streptococcus mutans y Enterococcus faecalis). Material and Method: The bacterial species were planted in 30 Petri plates fortified in their own ways, where also were placed the cements; then they were taken to the incubator at 37ºC by anaerobic means; in order to take notes of the different diameters of the halos of inhibition and others observations at 24, 48 and 168 hours on the registration sheets. Results: The antibacterial effect of the study coments is maintained during the 24 and 48 hours, meanwhile to others bacterias it is reduce slawly between the 48 and 168 hours. Conclusions: The three cements presented variable antibacterial effects on the strains studied; being the largest for the Super EBA, followed by Ketac Endo and the lowest for the MTA.