RESUMO
BACKGROUND: The lower third of the face and neck have distinct changes that occur with aging: the lost of the perfect jaw line due to laxicity of skin and fat deposits associated with "turkey neck." Theses changes can be globally and drastically addressed with traditional rhytidectomy, however patients increasingly seek less invasive procedures. Injections with Lipostabil Endovena-a mixture of phosphatidylcholine and deoxycholate, a bile salt-have been used to reduce unwanted, accumulated fat. Recent in vivo investigations indicate that phosphatidylcholine and deoxycholate cause adipocyte lysis, an inflammatory processes and fibrosis. These reactions lead to skin retraction. OBJECTIVE: This paper reports the author's experience treating aging neck using Lipostabil Endovena. RESULTS: Laxity of the skin improved in all patients. A marked reduction in double chins was noted and the jaw line was reconstructed. Adverse effects, including transient burning, erythema and local swelling were present in all patients, but resolved themselves without intervention. CONCLUSION: The author's clinical experience supports the conclusion that Lipostabil Endovena treats subcutaneous fat tissue and that fibrosis after the inflammatory process retracts the skin, tightening the injected area and improving the aging neck.
Assuntos
Técnicas Cosméticas , Fosfatidilcolinas/administração & dosagem , Envelhecimento da Pele/efeitos dos fármacos , Gordura Subcutânea/efeitos dos fármacos , Adulto , Queixo , Técnicas Cosméticas/efeitos adversos , Feminino , Seguimentos , Humanos , Arcada Osseodentária , Masculino , Pessoa de Meia-Idade , Pescoço , Fosfatidilcolinas/efeitos adversos , Rejuvenescimento , Resultado do TratamentoRESUMO
This article describes the author's experience with lipodissolve, a nonsurgical treatment to reduce fat deposits via the injection of a single component, phosphatidylcholine, a natural product found in the body. Lipodissolve is a relatively new aesthetic procedure used to dissolve smallish, localized, and defined zones of fat in the face and body.
Assuntos
Lipólise/fisiologia , Fosfatidilcolinas/uso terapêutico , Cirurgia Plástica/métodos , Tecido Adiposo/efeitos dos fármacos , Adulto , Envelhecimento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço , Fosfatidilcolinas/farmacologiaRESUMO
BACKGROUND: Subcutaneous injection of Lipostabil Endovena (Nattermann & Cie, Köln, Germany) has been used to treat periorbital fat pads, as well as localized fat deposits in the abdomen, neck, arms, and thighs. OBJECIVE: The goal of this article was to identify complications resulting from the use of Lipostabil Endovena for treating fat deposits. METHODS: A prospective study was conducted to identify complications associated with injection lipolysis with Lipostabil Endovena. Patients were surveyed at 48 hours, 2 weeks, and 2 months after the last injection session. RESULTS: The 739 patients surveyed received a total of 2852 vials injected. No general symptoms, such as fever, dizziness, gastrointestinal disturbances, or visual disturbances occurred, although local symptoms, including edema, hematoma, pain, and nodules, were reported. CONCLUSIONS: The lack of any reported general complications after injection lipolysis with Lipostabil Endovena is encouraging. However, larger studies are needed to confirm that the use of Lipostabil Endovena is safe.
RESUMO
BACKGROUND: Subcutaneous phosphatidylcholine to cause local lipolysis has been performed effectively and safely in the nonsurgical treatment of periorbital fat pads and also in the treatment of localized fat deposits in the abdomen, neck, arms and thighs. However, the studies do not explain the mechanism through which injectable phosphatidylcholine causes localized fat reduction. This study aimed to compare the local action of a phosphatidylcholine formulation with that of a physiologic saline solution in a histologic study investigating the fat tissue of rabbits. METHODS: Using a randomized, blind approach, 10 rabbits were injected with an experimental assay of phosphatidylcholine (the biologic model), and another 10 rabbits were injected with physiologic saline. A histologic study was conducted, and the Mann-Whitney test was applied. RESULTS: A marked difference was observed between the two groups with respect to necrosis, inflammatory exudation, and fibrosis. CONCLUSION: Necrosis of the fat cells in all the phosphatidylcholine-injected animals was observed. Further studies should be performed to clarify and determine the mechanisms of action.