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1.
Mol Nutr Food Res ; 68(18): e2300050, 2024 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-39205544

RESUMO

Omega-3 (ω3) fatty acids are widely investigated for their anti-inflammatory potential, however, there is little evidence regarding their action in the lung parenchyma in the context of obesity. The objective is to investigate the effects of flaxseed oil (FS), rich in α-linolenic (C18:3 - ω3), on the lungs of obese mice. Mice were fed a high-fat diet (HF) for 8 weeks to induce obesity. Subsequently, a part of these animals received HF containing FS oil for another 8 weeks. The HF consumption induced weight gain and hyperglycemia. The lung parenchyma shows a complete fatty acids profile, compared to the control group (CT). In the lung parenchyma, FS increases the ω3 content and, notwithstanding a reduction in the interleukins (IL) IL1ß and IL18 contents compared to HF. However, FS promoted increased alveolar spaces, followed by MCP1 (Monocytes Chemoattractant Protein-1) positive cell infiltration and a dramatic reduction in the anti-inflammatory cytokine, IL10. Despite reducing the pulmonary inflammatory response, the consumption of a food source of ω3 was associated with alterations in the lipid profile and histoarchitecture of the lung parenchyma, which can lead to the development of pulmonary complications. This study brings an alert against the indiscriminate use of ω3 supplements, warranting caution.


Assuntos
Dieta Hiperlipídica , Óleo de Semente do Linho , Pulmão , Obesidade , Animais , Óleo de Semente do Linho/farmacologia , Óleo de Semente do Linho/administração & dosagem , Dieta Hiperlipídica/efeitos adversos , Pulmão/efeitos dos fármacos , Pulmão/patologia , Pulmão/metabolismo , Obesidade/dietoterapia , Obesidade/metabolismo , Masculino , Camundongos Endogâmicos C57BL , Camundongos , Camundongos Obesos , Interleucina-1beta/metabolismo , Interleucina-18/metabolismo , Quimiocina CCL2/metabolismo , Interleucina-10/metabolismo , Ácidos Graxos Ômega-3/farmacologia , Ácidos Graxos Ômega-3/administração & dosagem , Aumento de Peso/efeitos dos fármacos
2.
J Nutr Biochem ; 114: 109270, 2023 04.
Artigo em Inglês | MEDLINE | ID: mdl-36706930

RESUMO

It is known that long-term high-fat diet (HF) feeding drastically affects the adipose tissue, contributing to metabolic disorders. Recently, short-term HF consumption was shown to affect different neuronal signaling pathways. Thus, we aimed to evaluate the inflammatory effects of a short-term HF and whether a diet containing omega-3 fatty acid fats from flaxseed oil (FS) has protective effects. Mice were divided into three groups for 3 d, according to their diets: Control group (CT), HF, or FS for 3 d. Lipid profiles were assessed through mass spectrometry and inflammatory markers by RT-qPCR and Western blotting. After short-term HF, mice increased food intake, body weight, adiposity, and fasting glucose. Increased mRNA content of Ccl2 and Tnf was demonstrated in the HF compared to CT in mesenteric adipose tissue. In the liver, TNFα protein was higher in the HF group than in CT, followed by a decreased polyunsaturated fatty acids tissue incorporation in HF. On the other hand, the consumption of FS reduced food intake and fasting glucose, as well as increased omega-3 fatty acid incorporation in MAT and the liver. However, short-term FS was insufficient to control the early inflammation triggered by HF in MAT and the liver. These data demonstrated that a 3-d HF diet is enough to damage glucose homeostasis and trigger inflammation. In contrast, short-term FS protects against increased food intake and fasting glucose but not inflammation in mice.


Assuntos
Dieta Hiperlipídica , Ácidos Graxos Ômega-3 , Camundongos , Animais , Dieta Hiperlipídica/efeitos adversos , Óleo de Semente do Linho/farmacologia , Ácidos Graxos Ômega-3/farmacologia , Ácidos Graxos Ômega-3/metabolismo , Inflamação/metabolismo , Tecido Adiposo/metabolismo , Glucose/metabolismo , Camundongos Endogâmicos C57BL
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