1.
Assoc Gen Pract Jamaica Newsl
; 5(4): 23, Mar. 1986.
Artigo
em Inglês
| MedCarib
| ID: med-10477
2.
Arq Neuropsiquiatr
; 43(1): 11-6, 1985 Mar.
Artigo
em Português
| MEDLINE
| ID: mdl-3925929
RESUMO
Single doses of phenytoin (500 and 1.000 mg), carbamazepine 400 and 1.00 mg) and sodium valproate (600 mg) were given orally to 5 healthy young volunteers and serum concentrations determined between 1-8h after administration. The design was double-blind and placebo-controlled. Serum concentrations considered "therapeutic" were obtained after sodium valproate and the 100 mg dose of carbamazepine. The results suggest the loading-doses of phenytoin (1500-2000 mg) and carbamazepine (800 mg) are useful in the subacute control of frequent epileptic seizures on an out-patient basis, and that carbamazepine may be used for lasting control of seizures of status epilepticus treated initially with diazepam or other rapidly-acting preparation.