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The Graded Prognostic Assessment (GPA) score has the best accuracy among prognostic scales for patients with brain metastases (BM). A wide range of GPA-derived scales have been established to different types of primary tumor BM. However, there is a high variability between them, and their characteristics have not been described altogether yet. We aim to summarize the features of the existent GPA-derived scales and to compare their predictor factors and their uses in clinical setting. Medline was searched from inception until January 2023 to identify studies related to the development, update, or validation of GPA. The initial search yielded 1,083 results. 16 original studies and 16 validation studies were included, comprising a total of 33,348 patients. 13 different scales were assessed, including: GPA, Diagnosis-Specific GPA, Extracranial Score, Lung-molGPA, Updated Renal GPA, Updated Gastrointestinal GPA, Modified Breast GPA, Integrated Melanoma GPA, Melanoma Mol GPA, Sarcoma GPA, Hepatocellular Carcinoma GPA, Colorectal Cancer GPA, and Uterine Cancer GPA. The most prevalent prognostic predictors were age, Karnofsky Performance Status, number of BM, and presence or absence of extracranial metastases. Treatment modalities consisted of whole brain radiation therapy, stereotactic radiosurgery, surgery, cranial radiotherapy, gamma knife radiosurgery, and BRAF inhibitor therapy. Median survival rates with no treatment and with a specific treatment ranged from 6.1 weeks to 33 months and from 3.1 to 21 months, respectively. Original GPA and GPA-derived scales are valid prognostic tools, but with heterogeneous survival results when compared to each other. More studies are needed to improve scientific evidence of these scales.

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The COVID-19 pandemic changed the routines of people, consequently changing the daily lives of their pets. Behavioral and emotional changes caused by the stress resulting from restrictions of social isolation and their consequences in the human-animal relationship have been discussed. However, there are still no studies that identify the factors that affect behavior and which are the most susceptible groups. The purpose of this study is to identify behavioral and emotional changes on dogs during the COVID-19 pandemic and their effects on the quality of life of animals and their owners. The methodology used was online questionnaires, which were posted on social networks aimed to dog owners in Rio de Janeiro state, Brazil. The results showed that age, sex, dog size, type of home, and restrictions imposed differently affected the type of behavioral change. However, the most frequent type of change was the worsening of previous conditions. Neutered behaviors directly interfered in the lives of owners and their pets, as owners managed the situation and sought information without guidance from a veterinarian, with the possibly consequence of worsening the situation in the future. Veterinarians should actively investigate behavioral changes that have occurred through anamnesis to avoid abandonment and instability in the human-animal relationship.

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Objetivo: compreender a utilização de tecnologias leves por profissionais de enfermagem na assistência a pacientes hospitalizados com covid-19. Método: estudo de abordagem qualitativa, desenvolvido com 23 profissionais de enfermagem, de hospitais de referência, para atendimento de pessoas com covid-19, entre maio e junho de 2021. A técnica de coleta de dados utilizada foi entrevista semiestruturada. Utilizou-se o referencial teórico-analítico da Análise de Discurso, de matriz francesa. Resultados: elaboraram-se as formações discursivas necessidades de saúde de pessoas hospitalizadas por covid-19, na perspectiva de profissionais de enfermagem; cuidados de enfermagem aos pacientes hospitalizados com covid-19 e tecnologias utilizadas; dificuldades enfrentadas na assistência de enfermagem aos pacientes hospitalizados com covid-19. Considerações finais: os profissionais de enfermagem não conseguiram identificar as tecnologias leves em suas práticas de cuidados, embora em seus discursos tenha sido identificado traços da utilização dessas tecnologias no seu cotidiano de trabalho.

Objetivo: comprender el uso de tecnologías ligeras por profesionales de enfermería en la asistencia a pacientes hospitalizados con covid-19. Método: estudio de abordaje cualitativo, desarrollado con 23 profesionales de enfermería, de hospitales de referencia, para atención de personas con covid-19, entre mayo y junio de 2021. La técnica de recolección de datos utilizada fue entrevista semiestructurada. Se utilizó el referencial teórico-analítico del Análisis de Discurso, de matriz francesa. Resultados: se elaboraron las formaciones discursivas necesidades de salud de personas hospitalizadas por covid-19, desde la perspectiva de profesionales de enfermería; cuidados de enfermería a los pacientes hospitalizados con covid-19 y tecnologías utilizadas; dificultades enfrentadas en la asistencia de enfermería a los pacientes hospitalizados con covid-19. Consideraciones finales: los profesionales de enfermería no consiguieron identificar las tecnologías ligeras en sus prácticas de atención, aunque en sus discursos se identificaron rasgos de la utilización de esas tecnologías en su cotidiano de trabajo.

Objective: to understand the use of light technologies by nursing professionals in the care of hospitalized patients with covid-19. Method: qualitative study, developed with 23 nursing professionals, from reference hospitals for care of people with covid-19, between May and June 2021. The data collection technique used was semi-structured interview. The theoretical-analytical framework of Discourse Analysis, of French matrix, was used. Results: the discursive training of health needs of people hospitalized with covid-19 was developed from the perspective of nursing professionals; nursing care for hospitalized patients with covid-19 and technologies used; difficulties faced in nursing care for hospitalized patients with covid-19. Final considerations: nursing professionals could not identify the light technologies in their care practices, although their discourses revealed traces of the use of these technologies in their daily work.

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Emerging pollutants have received increasing attention because of their potential environmental risks. As conventional treatment processes are not able to completely remove emerging pollutants, such as drugs, for example, the adsorption process is considered a complementary treatment. However, after some time of use, the adsorbent solids used in this type of process become saturated and there may be a higher demand for replacement of these materials, resulting in a large amount of solid waste. In this context, the objective of this study was to evaluate regeneration techniques of adsorbent solid depleted with emerging tetracycline pollutant. For this, tests were performed using three regenerative methods - thermal, chemical and ultrasonic, where through them were analyzed the influence of temperature, type of solvent and sonification time, respectively. Virgin, saturated and regenerated solids were characterized by their physical structure, micro and mesopore distribution and scanning electron microscopy. For all techniques employed, the regeneration efficiency reached values ⁣⁣above 85%. Thermal treatments at 200°C, 100% methanol solution, 100% deionized water with 60 °C heating and ultrasonic treatment at 5 and 20 minutes were chosen as the most viable methods for the study of adsorption/desorption cycles. Compared to the others, the heat treatment at 200°C remained with consistent results until the sixth cycle, presenting a regenerative capacity of 90%. Therefore, it has been selected as the most suitable regenerative agent, ensuring that CAG can be regenerated and used repeatedly in the treatment of tetracycline contaminated waters.

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The color of the berries is an important aspect of the quality of table grapes and crucial for marketing. The 'Rubi' table grapes grown in the subtropical climate generally lack color intensity due to the inhibition of anthocyanins by high temperatures during ripening. The exogenous application of abscisic acid (S-ABA) can be used to overcome this problem as the accumulation of anthocyanins in the berry skin is regulated by this plant growth regulator. The objective of this study was to assess the effect of the exogenous application of S-ABA at different stages of ripening on color development in 'Rubi' table grapes using the soluble solids (SS) content as a marker of ripening. The study was conducted during two seasons in commercial vineyards. The first trial was conducted in Marialva, Parana, Brazil, during the 2019 summer season crop (harvest in December). S-ABA (400 mg L-1) was exogenously applied at different stages of ripening of 'Rubi' table grapes (determined by the SS content of the berries): control (without application); SS = 8-9 ºBrix; SS = 10-11 ºBrix; SS = 8-9 ºBrix (two applications; the second one applied 10 days after the first); and SS = 10-11 ºBrix (two applications; the second one applied 10 days after the first). The second trial was conducted in Cambira, Parana, Brazil, during the 2020 off-season crop (harvest in May). S-ABA (400 mg L-1) was exogenously applied at different stages of ripening of 'Rubi' grapes: control (without application); SS = 6-7 ºBrix; SS = 7-8 ºBrix; SS = 9-10 ºBrix; SS = 6-7 ºBrix (two applications; the second one applied 14 days after the first); SS = 7-8 ºBrix (two applications; the second one applied 14 days after the first); and SS = 9-10 ºBrix (two applications; the second one applied 14 days after the first).(AU)

A cor das bagas é um aspecto importante de qualidade e comercialização de uvas de mesa. A uva fina de mesa 'Rubi' produzida em clima subtropical geralmente apresenta deficiência de cor devido à inibição da formação de antocianinas pelas altas temperaturas durante a maturação. Um dos métodos utilizados para superar esse problema é a aplicação exógena de ácido abscísico (S-ABA), uma vez que o acúmulo de antocianinas na casca das bagas é controlado por esse regulador vegetal. O objetivo deste trabalho foi determinar o efeito da aplicação do S-ABA em diferentes fases de maturação no desenvolvimento da cor da uva fina de mesa 'Rubi', visando o incremento e uniformização da cor dos seus cachos, tendo como referência o teor de sólidos solúveis (SS) das bagas. O experimento foi avaliado em dois ensaios a campo, em pomares comerciais. O primeiro ensaio foi realizado em Marialva, Paraná, Brasil, durante a safra de verão (colheita em dezembro) de 2019. Os tratamentos foram constituídos da aplicação de S-ABA na concentração de 400 mg L-1, em diferentes fases de maturação da uva 'Rubi', de acordo com o teor de SS das bagas, assim descritos: controle (sem aplicação); SS = 8-9 ºBrix; SS = 10-11 ºBrix; SS = 8-9 ºBrix em duas aplicações, sendo a segunda realizada aos 10 dias após a primeira; e SS = 10-11 ºBrix, em duas aplicações, sendo a segunda realizada aos 10 dias após a primeira. O segundo ensaio foi realizado em Cambira, Paraná, Brasil, durante a safra temporona ou de outono (colheita em maio) de 2020. Os tratamentos foram constituídos da aplicação de S-ABA na concentração de 400 mg.L-1 em diferentes fases de maturação da uva 'Rubi', de acordo com o teor de SS das bagas, assim descritos: controle (sem aplicação); SS = 6-7 ºBrix; SS = 7-8 ºBrix; SS = 9-10 ºBrix; SS = 6-7 ºBrix em duas aplicações, sendo a segunda realizada aos 14 dias após a primeira; SS = 7-8 ºBrix em duas aplicações, sendo a segunda realizada aos 14 dias após a primeira; e SS = 9-10 ºBrix em duas aplicações, sendo a segunda realizada aos 14 dias após a primeira. O delineamento experimental de ambos experimentos foi em blocos casualizados com 4 repetições, sendo que cada parcela foi composta por uma videira. As variáveis analisadas foram antocianinas totais, índice de cor (CIRG), e atributos (L*, C*, h° e ΔE) das bagas.(AU)

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ABSTRACT The garden fleahopper, Microtechnites bractatus (Say) (Hemiptera: Miridae), is associated with several cultivated plant species and, despite its economic importance, little is known about its development and performance in such hosts. We described here, the morphology of immature stages, and evaluated the biology of M. bractatus in beans, potatoes, white clover, alfalfa, and wheat. The bioassays were carried out in the laboratory under controlled temperature (25±2ºC), humidity (UR70±15%), and photoperiod (12L:12D). The eggs of M. bractatus are elongated and slightly curved, without respiratory projections and light yellow in color, becoming dark at the end of the incubation period. Nymphs present an oval-shaped body, a reddish color that intensifies along with the development and dimorphic wing pads in the fifth instar. In the bioassays, the host plants influenced the biological aspects of M. bractatus, both in the immature and adult stages. Nymph survival was higher in clover and alfalfa, while in wheat, it was lower. Clover-fed insects had the longest longevity. The fecundity parameters and egg viability were favored in insects that fed on clover and alfalfa. The fertility life table showed that feeding M. bractatus with clover provides a higher net reproduction rate (R0) and a higher finite ratio of population increase (ʎ). This study contributes to bioecological and behavioral studies on M. bractatus and provides data for the recognition and characterization of individuals in the immature stage.

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ABSTRACT Objectives: to categorize factual elements of ethical-disciplinary nursing lawsuits in the state of Goiás. Methods: cross-sectional, retrospective study, based on secondary data obtained from ethical-disciplinary lawsuits filed at the Regional Nursing Council of Goiás (Coren-Goiás) between the years 2010 and 2019. Results: the highest number of lawsuits filed was in 2013 and 2014, with a greater frequency in the state capital. The majority came from the Nursing Ethics Committees and ex-officio complaints. The professional with most complaints was the nursing technician, aged between 31 and 40 years old, at the beginning of their career. The most common type of complaints referred to performing attributions that were not within the nursing competences. Conclusions: as a highlight are the contributions of this study to professional ethics in nursing and the clear need to consolidate these skills in nurses who are in training and in the continuous education for those already in the profession.

RESUMEN Objetivos: categorizar elementos fácticos de los procesos ético-disciplinarios de enfermería en Goiás. Métodos: estudio transversal, retrospectivo, basado en datos secundarios obtenidos de procesos ético-disciplinarios denunciados en el Consejo Regional de Enfermería de Goiás (CorenGoiás) entre 2010 y 2019. Resultados: el mayor número de procesos instaurados fue en 2013 y 2014, con mayor frecuencia en la capital del estado. La mayoría advino de las Comisiones de Ética de Enfermería y denuncias de oficio. El profesional más denunciado fue el técnico de enfermería, en la franja etaria entre 31 y 40 años, en inicio de carrera. El tipo de denuncia más común se referió a ejercer atribuciones que no son competencias de enfermería. Conclusiones: destacada la contribución de este estudio para la ética profesional en enfermería y necesidad clara de consolidación de esas competencias en el profesional en formación y educación permanente para aquellos que se encuentran en ejercicio de la profesión.

RESUMO Objetivos: categorizar elementos fáticos dos processos ético-disciplinares de enfermagem no estado de Goiás. Métodos: estudo transversal, retrospectivo, com base em dados secundários obtidos de processos ético-disciplinares autuados no Conselho Regional de Enfermagem de Goiás (CorenGoiás) entre os anos de 2010 e 2019. Resultados: o maior número de processos instaurados foi nos anos 2013 e 2014, com maior frequência na capital do estado. A maioria adveio das Comissões de Ética de Enfermagem e das denúncias de ofício. O profissional mais denunciado foi o técnico de enfermagem, na faixa etária entre 31 e 40 anos, no início da carreira. O tipo de denúncia mais comum referiu-se a exercer atribuições que não são competências da enfermagem. Conclusões: destaca-se a contribuição deste estudo para a ética profissional em enfermagem e a necessidade clara de consolidação dessas competências no profissional em formação e de educação permanente para aqueles que se encontram em exercício da profissão.

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OBJECTIVES: to categorize factual elements of ethical-disciplinary nursing lawsuits in the state of Goiás. METHODS: cross-sectional, retrospective study, based on secondary data obtained from ethical-disciplinary lawsuits filed at the Regional Nursing Council of Goiás (Coren-Goiás) between the years 2010 and 2019. RESULTS: the highest number of lawsuits filed was in 2013 and 2014, with a greater frequency in the state capital. The majority came from the Nursing Ethics Committees and ex-officio complaints. The professional with most complaints was the nursing technician, aged between 31 and 40 years old, at the beginning of their career. The most common type of complaints referred to performing attributions that were not within the nursing competences. CONCLUSIONS: as a highlight are the contributions of this study to professional ethics in nursing and the clear need to consolidate these skills in nurses who are in training and in the continuous education for those already in the profession.

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OBJECTIVE: To report the experience of the nursing supervised curricular internship in the program "O Brasil Conta Comigo" carried out in the Covid-19 pandemic. METHOD: Experience report of activities developed in Primary Health Care in a municipality in the southern region of the state of Goiás during the Covid-19 pandemic, from April to November 2020. RESULTS: The inclusion in the government program allowed the strengthening of the student's active role in the teaching-learning process and teaching-service approximation, with the student as the point of connection, which resulted in the implementation of actions for the fight against the pandemic in the municipality, such as elaboration, implementation, and evaluation of the service flowchart for people with suspected Covid-19. CONCLUSION: The experience was successful, as it consolidated knowledge regarding leadership and autonomy, integration between theory and practice, critical thinking, and evidence-based problem solving. The participation in the program allowed for contributions to assistance and management in the actions to combat the new coronavirus in the scope of primary care, as well as for the contribution to the training of the student tutored by nurses in the field and supervised by professors from the federal university of origin.

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OBJECTIVES: to assess the quality of life of master's and doctoral students in health. METHODS: this is a cross-sectional study carried out with 503 master's and doctoral students from the Brazilian Center-West, using the WHOQOL-BREF to analyze their quality of life. Analysis included Cronbach's alpha coefficient, confirmatory factor analysis and bivariate and multivariate analyzes. RESULTS: older age and having a child were associated with higher average quality of life scores, while diagnosis of anxiety/depression, difficulty in managing academic and personal activities and thinking about dropping out of course were associated with lower average scores in quality of life domains (p <0.05). CONCLUSIONS: master's and doctoral students have reduced quality of life during the entire training period, mainly in psychological and physical health. The management of academic activities and dropping out of course are the main variables associated with decreased students' quality of life.

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OBJECTIVE: Cardiovascular risk stratification is an important clinical practice to estimate the severity of cardiovascular disease in patients with type 2 diabetes. This study aimed to compare the stratification of global cardiovascular risk with the specific risk stratification for patients with type 2 diabetes, seen at specialized outpatient clinics, and to evaluate possible differences in diagnoses and treatments. METHODS: A total of 122 patients with type 2 diabetes treated at two specialized outpatient clinics, from 2017 to 2019, were studied. The cardiovascular risk stratification calculators, global risk score, Cardiovascular Risk Stratification Calculator, and United Kingdom Prospective Diabetes Study-Risk Engine, were used to calculate the risk of death from cardiovascular disease. The agreement between these calculators was analyzed using the kappa index. The indications for the use of statins and acetylsalicylic acid for the group studied were evaluated according to the Brazilian Diabetes Society Guideline. RESULTS: There was a low degree of agreement among the three risk calculators. The global risk score calculator showed insignificant agreement with the Cardiovascular Risk Stratification Calculator (kappa=0.0816; p=0.0671). There was no agreement between the global risk score calculator and United Kingdom Prospective Diabetes Study-Risk Engine (kappa=-0.099), or between the Cardiovascular Risk Stratification Calculator and United Kingdom Prospective Diabetes Study-Risk Engine (kappa=-0.0095). CONCLUSION: The substantial disagreements among the cardiovascular risk calculators may lead to different diagnoses and may consequently influence therapeutic strategies. The findings herein highlight the need for specific validated cardiovascular risk calculators for patients with DM2 that can reliably estimate risk in these individuals.

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OBJECTIVE: to understand the representations about sexuality of people diagnosed late with HIV infection and its implications in the delayed search for diagnosis. METHODS: this is a qualitative study, whose theoretical and methodological framework was Social Representation Theory. The research was carried out with 18 people diagnosed late with HIV infection through an open interview. For data analysis, Structural Narration Analysis was used, with support from MAXQDA 12®. RESULTS: representations about sexuality contributed to delayed diagnosis, such as trust in a fixed partnership, sexual intercourse is natural, sexuality as a taboo, search for pleasure in sexual intercourse, regardless of risks, denial of risk for HIV infection. FINAL CONSIDERATIONS: representations about sexuality participate in a web of stereotypes and riskier ways of living, which contribute to delayed diagnosis. Sexual health education remains necessary and essential throughout people's lives.

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OBJECTIVE: To describe the construction of a nursing leadership succession plan for a hospital based on the appreciative reflection of nurses. METHOD: Descriptive exploratory study with a qualitative approach carried out with nurses in a federal public teaching hospital. Data collection was carried out in two stages. The first was an individual interview, and the second was group mediation conducted based on the 4D Cycle and the assumptions of Appreciative Inquiry. Descriptive analysis of the findings was carried out. RESULTS: The data showed a highly qualified team of different generations, concerned with succession planning based on scientific evidence, involving teams and carried out carefully for nurses at different stages of their professional careers. CONCLUSION: The principles of Appreciative Inquiry allowed the construction of a succession plan to enhance leadership development actions in the hospital. The collaborative environment between generations was valued and planning focused on participatory management was created in the process. This aspect can profoundly change the institution's internal policy in several areas and point out ways to implement succession planning in different contexts.

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SUMMARY OBJECTIVE: Cardiovascular risk stratification is an important clinical practice to estimate the severity of cardiovascular disease in patients with type 2 diabetes. This study aimed to compare the stratification of global cardiovascular risk with the specific risk stratification for patients with type 2 diabetes, seen at specialized outpatient clinics, and to evaluate possible differences in diagnoses and treatments. METHODS: A total of 122 patients with type 2 diabetes treated at two specialized outpatient clinics, from 2017 to 2019, were studied. The cardiovascular risk stratification calculators, global risk score, Cardiovascular Risk Stratification Calculator, and United Kingdom Prospective Diabetes Study-Risk Engine, were used to calculate the risk of death from cardiovascular disease. The agreement between these calculators was analyzed using the kappa index. The indications for the use of statins and acetylsalicylic acid for the group studied were evaluated according to the Brazilian Diabetes Society Guideline. RESULTS: There was a low degree of agreement among the three risk calculators. The global risk score calculator showed insignificant agreement with the Cardiovascular Risk Stratification Calculator (kappa=0.0816; p=0.0671). There was no agreement between the global risk score calculator and United Kingdom Prospective Diabetes Study-Risk Engine (kappa=-0.099), or between the Cardiovascular Risk Stratification Calculator and United Kingdom Prospective Diabetes Study-Risk Engine (kappa=-0.0095). CONCLUSION: The substantial disagreements among the cardiovascular risk calculators may lead to different diagnoses and may consequently influence therapeutic strategies. The findings herein highlight the need for specific validated cardiovascular risk calculators for patients with DM2 that can reliably estimate risk in these individuals.

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Objetivou-se avaliar o comportamento fenológico, e as características físico-químicas e produtivas da videira ‘BRS Carmem’ cultivadas em Palotina, PR. A avaliação das videiras enxertadas sobre IAC 572 ‘Tropical’, espaçadas em 1,5 x 2,5 m, e conduzidas em espaldeira foi realizada nas safras 2019/2020 e 2020/2021. Foram utilizadas 20 plantas representativas do pomar experimental da UFPR –Setor Palotina. A avaliação do comportamento fenológico foi realizada a partir de observação de ramos selecionados, a partir da poda de frutificação realizada em meados de agosto, caracterizando-se a duração em dias de cada um dos seguintes subperíodos: poda à gema-algodão (PO-GA); poda à brotação (PO-BR); poda ao aparecimento da inflorescência (PO-AI); poda ao florescimento (PO-FL); poda ao início da maturação (PO-IM) das bagas; poda à colheita (PO-CO), sendo confeccionados diagramas em escala de dias. Por ocasião da colheita quantificou-se o número de cachos por planta, massa dos cachos e a partir destes dados foram estimadas a produção (kg planta-1) e produtividade (t ha-1). Para avaliaçãodo mosto foram coletados dois cachos por planta, dos quais retirou-se seis bagas por cachopara avaliação do teor de sólidos solúveis (SS), acidez titulável (AT), relação de índice de maturação (SS/AT) e o teor de antocianinas (mg g-1). Quanto ao número de cachos verificou se em média 48 cachos por planta com massa média de 133 g. As estimativas da produção por planta e produtividade foram de 6,4 kg e 17,1 t ha-1, respectivamente. Os teores médios de SS, AT, SS/AT e antocianinas, foram de 18°Brix, 0,97% deácido tartárico, 18,4 e 4,97 mg g-1, respectivamente. As características produtivas e a qualidade do mosto da ‘BRS Carmem’ cultivadas na região Oeste do Paraná estão dentro dos padrões desejáveis para elaboração de suco de uva.

The objective of this study was to evaluate the phenological behavior and the physical-chemical and productive characteristics of the ‘BRS Carmem’ vine grown in the Western region of Paranástate (Brazil). The evaluation of vines grafted on IAC 572 ‘Tropical’, spaced at 1.5 x 2.5 m, and conducted on a backrest was performed in the harvests 2019/2020 and 2020/2021. Twenty plants representing the experimental orchard of UFPR -Palotina Sector were used. The evaluation of phenological behavior was performed from observation of selected branches, from the fruiting pruning carried out in mid-August, characterizing the duration in days of each of the following subperiods: cotton yolk pruning (PO-GA); pruning to sprouting (PO-BR); pruning to the appearance of inflorescence (PO-AI); pruning to flowering(PO-FL); pruning at the beginning of ripening (PO-IM) of the berries; pruning to harvest (PO-CO), and diagrams were made on a day scale. At the harvesttime, the number of bunchesper plant, mass of bunches was quantified and from these data the production (kg plant-1) and the productivity (t ha-1) were estimated. To evaluate the must, two bunches per plant were collected, and six berries were collected per bunch to evaluate soluble solids content (SS), titratable acidity (TA), maturation index ratio (SS/TA) and anthocyanin content (mg g-1). For the number of bunches was verified an average of 48 bunches per plant, with an average mass of 133 g. The production per plantand yieldestimateswere 6.4 kg and 17.1 t ha-1, respectively. The mean levels of SS, AT, SS/AT and anthocyanins were 18°Brix, 0.97% of tartaric acid, 18.4 and 4.97 mg g-1, respectively. Therefore, theproductivecharacteristics and the quality of the 'BRS Carmem' cultivated in the Western region of Paraná state are within the desirable standards for grape juicepreparation.

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The aim of this work was to evaluate different SO2-generating pads and liners to control gray mold in ventilated clamshell-packaged 'Rubi' table grapes grown under a two-cropping per year system. The treatments consisted of SO2-generating pads (slow release or dual release) and plastic liners with different perforations (microperforated; 2.0; 4.0 or 5.0 mm in diameter) and a control, only with the standard microperforated plastic liner. The packaged grapes were stored in a cold chamber at 1.0 ± 1.0 °C and 95% relative humidity. After 45 days, the grapes were removed from cold storage and placed, without liners and SO2-generating pads, for 3 days at room temperature (22.0 ± 1.0 °C). The evaluations occurred at 30 and 45 days after the beginning of cold storage, and the following variables were assessed: incidence of gray mold, mass loss, stem browning and shattered berries. At 3 days of shelf-life, the same variables were assessed, except mass loss. The completely randomized design was used as a statistical model with four replications, and each plot consisted of five bunches individually stored in ventilated clamshell-packaged. The dual release SO2-generating pads are efficient in controlling the gray mold in 'Rubi' table grapes regardless of the type of perforation of the plastic liners, with low mass loss and shattered berries, with good conservation of the freshness of the rachis. The disease was efficiently controlled in both annual crops. The slow-release SO2-generating pads, regardless of the type of perforation of the plastic liners, resulted in intermediate efficiency of gray mold control, with good physical quality of the bunches. Thus, the use of dual release SO2- generating pads is recommended to control gray mold in ventilated clamshell-packaged 'Rubi' table grapes.(AU)

O objetivo deste trabalho foi avaliar diferentes folhas geradoras de SO2 e filmes plásticos perfurados, no controle do mofo cinzento em uvas de mesa 'Rubi' armazenadas individualmente em cumbucas plásticas ventiladas cultivadas sob dupla safra anual. Os tratamentos foram constituídos por folhas geradoras de SO2 (liberação lenta ou liberação dupla fase) e filmes plásticos com diferentes perfurações (microperfurado; 2,0; 4,0 ou 5,0 mm de diâmetro) e uma testemunha, somente com o filme plástico microperfurado. As uvas foram armazenadas em câmara refrigerada a 1,0 ± 1,0 °C e 95% de umidade relativa do ar. Após 45 dias, as uvas foram retiradas e mantidas sem os filmes plásticos e as folhas de SO2 por 3 dias em temperatura ambiente (22,0 ± 1,0 °C). As avaliações ocorreram aos 30 e 45 dias após o início do armazenamento refrigerado, quando foram analisadas as seguintes variáveis: incidência de mofo cinzento, perda de massa, escurecimento da ráquis e degrana de bagas. Aos 3 dias em temperatura ambiente, as mesmas variáveis foram novamente avaliadas, com exceção da perda de massa. O delineamento experimental foi inteiramente casualizado, com quatro repetições por tratamento, sendo cada parcela composta por cinco cachos armazenados individualmente em cumbucas plásticas ventiladas. Verificou-se que a folha de liberação dupla fase de SO2 é eficiente no controle do mofo cinzento nas uvas de mesa 'Rubi', independente do tipo de perfuração do filme plástico, com baixa perda de massa e degrana, e boa conservação do frescor da ráquis. A doença foi controlada com eficiência nas duas safras anuais. A folha de liberação lenta de SO2, independente do tipo de perfuração do filme plástico, resultou em eficiência intermediária de controle do mofo cinzento, com boa qualidade física dos cachos. A folha de liberação dupla fase de SO2 é recomendada para o controle do mofo cinzento em uvas de mesa 'Rubi' embaladas em cumbucas plásticas ventiladas.(AU)

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Resumo Com o passar dos anos, os pacientes têm procurado tratamentos ortodônticos com altas expectativas, em relação a resultado/qualidade, tempo e propostas mais estéticas de tratamento. Muitos afirmam que aparelhos vestibulares afetam diretamente sua autoestima e comprometem o seu bem-estar social. Neste artigo será exposto o relato de um caso clínico de uma paciente do sexo feminino, que buscou um tratamento ortodôntico confortável e imperceptível. A técnica 3D-BOT utilizada faz uso de fixação do fio nas faces oclusal dos dentes posteriores e lingual dos dentes anteriores, o que faz com que leigos não percebam a existência de tratamento ortodôntico, nem mesmo quando muito próximos ao paciente. Buscando refinar o tratamento foram utilizados alinhadores sequenciais digitais no arco superior apenas. Para a conclusão do caso relatado foi necessário um total de 12 visitas e as queixas principais da paciente, bem como as metas ortodônticas, funcionais e estéticas foram atingidas de uma forma imperceptível e sem atrapalhar a autoestima e o convívio social da paciente. (AU)

Absctract Over the years, patients have sought orthodontic treatments with high expectations, in relation to result/quality, time and more aesthetic treatment proposals. Many claim that vestibular devices directly affect their self-esteem and compromise their social well-being. This article will present a clinical case report of a female patient who sought a comfortable and imperceptible orthodontic treatment. The 3D-BOT technique used, makes use of wire fixation on the occlusal surface of posterior teeth and lingual of anterior teeth, which makes laypeople not realize the existence of orthodontic treatment, even when very close to the patient. Seeking to refine the treatment, sequential digital aligners were used in the upper arch only. To conclude the case reported a total of 12 visits were required and the patient's main complaints as well as the orthodontic, functional, and aesthetic goals were achieved, in an imperceptible way and without interfering with the patient's self-esteem and social life.(AU)

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Objetivou-se avaliar o comportamento fenológico, e as características físico-químicas e produtivas da videira ‘BRS Carmem cultivadas em Palotina, PR. A avaliação das videiras enxertadas sobre IAC 572 ‘Tropical, espaçadas em 1,5 x 2,5 m, e conduzidas em espaldeira foi realizada nas safras 2019/2020 e 2020/2021. Foram utilizadas 20 plantas representativas do pomar experimental da UFPR –Setor Palotina. A avaliação do comportamento fenológico foi realizada a partir de observação de ramos selecionados, a partir da poda de frutificação realizada em meados de agosto, caracterizando-se a duração em dias de cada um dos seguintes subperíodos: poda à gema-algodão (PO-GA); poda à brotação (PO-BR); poda ao aparecimento da inflorescência (PO-AI); poda ao florescimento (PO-FL); poda ao início da maturação (PO-IM) das bagas; poda à colheita (PO-CO), sendo confeccionados diagramas em escala de dias. Por ocasião da colheita quantificou-se o número de cachos por planta, massa dos cachos e a partir destes dados foram estimadas a produção (kg planta-1) e produtividade (t ha-1). Para avaliaçãodo mosto foram coletados dois cachos por planta, dos quais retirou-se seis bagas por cachopara avaliação do teor de sólidos solúveis (SS), acidez titulável (AT), relação de índice de maturação (SS/AT) e o teor de antocianinas (mg g-1). Quanto ao número de cachos verificou se em média 48 cachos por planta com massa média de 133 g. As estimativas da produção por planta e produtividade foram de 6,4 kg e 17,1 t ha-1, respectivamente. Os teores médios de SS, AT, SS/AT e antocianinas, foram de 18°Brix, 0,97% deácido tartárico, 18,4 e 4,97 mg g-1, respectivamente. As características produtivas e a qualidade do mosto da ‘BRS Carmem cultivadas na região Oeste do Paraná estão dentro dos padrões desejáveis para elaboração de suco de uva.(AU)

The objective of this study was to evaluate the phenological behavior and the physical-chemical and productive characteristics of the ‘BRS Carmem vine grown in the Western region of Paranástate (Brazil). The evaluation of vines grafted on IAC 572 ‘Tropical, spaced at 1.5 x 2.5 m, and conducted on a backrest was performed in the harvests 2019/2020 and 2020/2021. Twenty plants representing the experimental orchard of UFPR -Palotina Sector were used. The evaluation of phenological behavior was performed from observation of selected branches, from the fruiting pruning carried out in mid-August, characterizing the duration in days of each of the following subperiods: cotton yolk pruning (PO-GA); pruning to sprouting (PO-BR); pruning to the appearance of inflorescence (PO-AI); pruning to flowering(PO-FL); pruning at the beginning of ripening (PO-IM) of the berries; pruning to harvest (PO-CO), and diagrams were made on a day scale. At the harvesttime, the number of bunchesper plant, mass of bunches was quantified and from these data the production (kg plant-1) and the productivity (t ha-1) were estimated. To evaluate the must, two bunches per plant were collected, and six berries were collected per bunch to evaluate soluble solids content (SS), titratable acidity (TA), maturation index ratio (SS/TA) and anthocyanin content (mg g-1). For the number of bunches was verified an average of 48 bunches per plant, with an average mass of 133 g. The production per plantand yieldestimateswere 6.4 kg and 17.1 t ha-1, respectively. The mean levels of SS, AT, SS/AT and anthocyanins were 18°Brix, 0.97% of tartaric acid, 18.4 and 4.97 mg g-1, respectively. Therefore, theproductivecharacteristics and the quality of the 'BRS Carmem' cultivated in the Western region of Paraná state are within the desirable standards for grape juicepreparation.(AU)

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ABSTRACT Objectives: to assess the quality of life of master's and doctoral students in health. Methods: this is a cross-sectional study carried out with 503 master's and doctoral students from the Brazilian Center-West, using the WHOQOL-BREF to analyze their quality of life. Analysis included Cronbach's alpha coefficient, confirmatory factor analysis and bivariate and multivariate analyzes. Results: older age and having a child were associated with higher average quality of life scores, while diagnosis of anxiety/depression, difficulty in managing academic and personal activities and thinking about dropping out of course were associated with lower average scores in quality of life domains (p <0.05). Conclusions: master's and doctoral students have reduced quality of life during the entire training period, mainly in psychological and physical health. The management of academic activities and dropping out of course are the main variables associated with decreased students' quality of life.

RESUMEN Objetivos: evaluar la calidad de vida de los estudiantes de maestría y doctorado en el área de la salud. Métodos: estudio transversal, realizado con 503 estudiantes de maestría y doctorado del Medio Oeste brasileño, utilizando el WHOQOL-BREF para analizar su calidad de vida. El análisis incluyó el coeficiente alfa de Cronbach, el análisis factorial confirmatorio y los análisis bivariados y multivariados. Resultados: la edad avanzada y tener un hijo se asociaron con puntuaciones medias más altas para la calidad de vida, mientras que el diagnóstico de ansiedad/depresión, la dificultad para manejar las actividades académicas y personales y la idea de abandonar el curso se asociaron con puntuaciones medias más bajas en los dominios de calidad de vida (p<0,05). Conclusiones: los estudiantes de maestría y doctorado han reducido la calidad de vida durante todo el período de formación, principalmente en salud psicológica y física. La gestión de las actividades académicas y el abandono del curso son las principales variables asociadas a la disminución de la calidad de vida de estos estudiantes.

RESUMO Objetivos: avaliar a qualidade de vida de estudantes de mestrado e doutorado da área da saúde. Métodos: estudo transversal, realizado com 503 mestrandos e doutorandos do Centro-Oeste brasileiro, usando o WHOQOL-BREF para analisar sua qualidade de vida. A análise incluiu o coeficiente alfa de Cronbach, análise fatorial confirmatória e análises bivariada e multivariada. Resultados: maior idade e ter filho associaram-se com maiores escores médios de qualidade de vida, enquanto diagnóstico de ansiedade/depressão, dificuldade em gerir atividades acadêmicas e pessoais e pensar em desistir do curso foram associados a menores escores médios nos domínios da qualidade de vida (p<0,05). Conclusões: estudantes de mestrado e doutorado têm redução da qualidade de vida durante todo o período de formação, principalmente na saúde psicológica e física. A gestão das atividades acadêmicas e desistir do curso são as principais variáveis associadas a diminuição da qualidade de vida desses estudantes.