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1.
Psychiatry Res ; 195(1-2): 18-26, 2012 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-21824666

RESUMO

Previous studies have reported facial emotion recognition impairments in schizophrenic patients, as well as abnormalities in the N170 component of the event-related potential. Current research on schizophrenia highlights the importance of complexly-inherited brain-based deficits. In order to examine the N170 markers of face structural and emotional processing, DSM-IV diagnosed schizophrenia probands (n=13), unaffected first-degree relatives from multiplex families (n=13), and control subjects (n=13) matched by age, gender and educational level, performed a categorization task which involved words and faces with positive and negative valence. The N170 component, while present in relatives and control subjects, was reduced in patients, not only for faces, but also for face-word differences, suggesting a deficit in structural processing of stimuli. Control subjects showed N170 modulation according to the valence of facial stimuli. However, this discrimination effect was found to be reduced both in patients and relatives. This is the first report showing N170 valence deficits in relatives. Our results suggest a generalized deficit affecting the structural encoding of faces in patients, as well as the emotion discrimination both in patients and relatives. Finally, these findings lend support to the notion that cortical markers of facial discrimination can be validly considered as vulnerability markers.


Assuntos
Emoções , Potenciais Evocados/fisiologia , Face , Família/psicologia , Esquizofrenia/complicações , Psicologia do Esquizofrênico , Adulto , Análise de Variância , Discriminação Psicológica , Eletroencefalografia , Saúde da Família , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Estimulação Luminosa , Tempo de Reação/fisiologia , Reconhecimento Psicológico
2.
Psychiatry Res ; 185(1-2): 44-8, 2011 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-20580837

RESUMO

It is well established that schizophrenia is associated with difficulties in recognizing facial emotional expressions, but few studies have reported the presence of this deficit among their unaffected relatives. This study attempts to add new evidence of familial association on an emotional expression processing test. The study evaluated the performance of 93 paranoid schizophrenia patients, 110 first-degree relatives of probands from multiplex schizophrenia families, and 109 nonpsychiatric controls on a facial emotional recognition test using a computer morphing technique to present the dynamic expressions. The task entailed the recognition of a set of facial expressions depicting the six basic emotions presented in 21 successive frames of increasing intensity. The findings indicated that schizophrenia patients were consistently impaired for the recognition of the six basic facial expressions. In contrast, their unaffected relatives showed a selective impairment for the recognition of disgust and fearful expressions. Familial association of selective facial emotional expressions processing deficit may further implicate promising new endophenotypes that can advance the understanding of affective deficits in schizophrenia.


Assuntos
Emoções Manifestas/fisiologia , Saúde da Família , Transtornos da Memória/etiologia , Reconhecimento Psicológico/fisiologia , Esquizofrenia Paranoide/complicações , Adulto , Análise de Variância , Distribuição de Qui-Quadrado , Cuba , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Psicologia do Esquizofrênico , Adulto Jovem
3.
Eur Arch Psychiatry Clin Neurosci ; 259(8): 475-81, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19399358

RESUMO

The impairment of the Trail Making Test (TMT) performance as a measure of executive function deficits has been found both in patients with schizophrenia and in their unaffected first-degree relatives, suggesting that it might be considered as a familial vulnerability marker, but its heritability estimates are not well known. This study investigated the genetic heritability of impairments in TMT performance using a sample of 80 schizophrenia patients, 145 unaffected first-degree relatives and 127 healthy controls from families with multiple members with schizophrenia. Consistent with previous reports in the literature, relatives performed in between healthy controls and schizophrenia patients. Based on these results, a variance component-analysis provided small, but significant additive heritability estimates for performance indices relating performance in TMT-version A to TMT-version B. These results showed that this significant but small evidence of heritability on the one hand suggests an association with genetic predisposition to schizophrenia, but that TMT performance is also associated with epigenetic or environmental factors.


Assuntos
Transtornos Cognitivos/diagnóstico , Função Executiva/fisiologia , Família/psicologia , Fenótipo , Esquizofrenia/complicações , Esquizofrenia/genética , Psicologia do Esquizofrênico , Adolescente , Adulto , Idoso , Análise de Variância , Transtornos Cognitivos/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Teste de Sequência Alfanumérica , Adulto Jovem
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