RESUMO
The applicability of endosseous implants is directly related to the topography and quality of the patient's residual bone. Several techniques have tried to expand the applicability through implant design alterations and surgical techniques for bone augmentation. This article describes an implant-induced bone expansion procedure that facilitates the placement of implants in atrophic alveolar ridges. This procedure expands the cortical plates of the alveolar ridges with or without fracture using wedge-shaped implants and the principles of guided tissue regeneration. The use of implants of larger diameters and the remodeling of the ridge external contour can be achieved with this procedure.
Assuntos
Processo Alveolar/patologia , Implantação Dentária Endóssea/métodos , Implantes Dentários , Arcada Osseodentária/patologia , Osteotomia/métodos , Processo Alveolar/fisiopatologia , Processo Alveolar/cirurgia , Atrofia , Remodelação Óssea/fisiologia , Reabsorção Óssea/fisiopatologia , Reabsorção Óssea/cirurgia , Implantação Dentária Endóssea/instrumentação , Planejamento de Prótese Dentária , Seguimentos , Gengivoplastia , Regeneração Tecidual Guiada Periodontal/instrumentação , Regeneração Tecidual Guiada Periodontal/métodos , Humanos , Arcada Osseodentária/fisiopatologia , Membranas Artificiais , Procedimentos Cirúrgicos Ortognáticos , Osteotomia/instrumentação , Propriedades de Superfície , Retalhos Cirúrgicos , CicatrizaçãoRESUMO
1. Norepinephrine (NE) and clonidine produce a phasic, dose-dependent contraction of the isolated guinea-pig terminal ileum. 2. The effect of NE was blocked by prazosin which produced a parallel rightward shift of the concentration-effect curve to NE, with a significant depression of maximum effects. 3. Yohimbine and indomethacin noncompetitively blocked, whereas practolol potentiated, the contractile effect of NE. 4. The contractile effect of clonidine was not antagonized by indomethacin or atropine. 5. These results suggest that the isolated guinea-pig terminal ileum has excitatory receptors sensitive to clonidine stimulation and excitatory alpha receptors sensitive to blockade by prazosin, and that the activation of the latter may be related to the activation of endogenous prostaglandin synthesis.
Assuntos
Clonidina/farmacologia , Íleo/efeitos dos fármacos , Músculo Liso/efeitos dos fármacos , Norepinefrina/farmacologia , Animais , Atropina/farmacologia , Cobaias , Técnicas In Vitro , Indometacina/farmacologia , Masculino , Contração Muscular/efeitos dos fármacos , Practolol/farmacologia , Prazosina/farmacologia , Ioimbina/farmacologiaRESUMO
In the present study we describe the morphological and morphometric alterations induced by Bolivia strain of the Trypanosoma cruzi in the mouse parotid gland during the acute period of infection. The acinar cells exhibit reduced eosinophilia, greater chromatin condensation, reduced height and consequent dislocation of the nucleus towards the basal pole. Then lumen is reduced. The ducts are dilated and lined with low cylindrical epithelium. The septa are wider. An intense lymphoplasmocytic infiltrate is present. Amastigotes was found in glandular acini cells, striated duct cells, inter and intralobular connective tissue, muscle walls of blood vessels, and inside the striated duct lumen.
Assuntos
Doença de Chagas/patologia , Glândula Parótida/patologia , Doença Aguda , Animais , CamundongosRESUMO
In the present study we describe the morphological and morphometric alterations induced by Trypanosoma cruzi (Bolivia strain) on the mice parotid gland, and the action of cocaine on the development of the gland of growing infected animals. The acinar cells of animals inoculated 28 d after birth showed reduced eosinophilia, greater chromatin condensation, reduced height, and basally dislocated nucleus. The area occupied by the acini was decreased and the nuclear volume was reduced. Reduced height of epithelial cells and decreased nuclear volume occurred in the striated and excretory ducts. The presence of lymphoplasmocyte infiltrates was also observed. The present results indicate delayed development of the infected mouse parotid gland. Our results indicate that cocaine perceptibly reduced the atrophy of the acinar cells and minimized the histopathological changes caused by T. cruzi in the parotid gland, in addition to significantly increasing the survival of infected animals. The presence of stroma with dilated capillaries and frequent inflammatory infiltrates showed that cocaine does not interfere with the inflammatory response.
Assuntos
Doença de Chagas/patologia , Cocaína/farmacologia , Neurotoxinas/metabolismo , Trypanosoma cruzi/metabolismo , Animais , Atrofia , Masculino , Camundongos , Neurotoxinas/biossíntese , Glândula Parótida/patologiaRESUMO
The anticholinesterase (antiChE) activity of ranylcypromine (TRCY) and its isomers was studied by employing dog plasma as a cholinesterase source. Changes in arterial blood pressure, elicited by a mixture of acetylcholine (Ach) and dog plasma with or without those drugs, as an indicator of their anti ChE activity were monitored. When TRCY or one of its isomers was present in concentrations higher than 125 microM in plasma containing Ach, the hypotensive effect of the latter was preserved. Such findings provide experimental evidence that TRCY and its isomers may exert antiChE activity.