RESUMO
1. Carbohydrate-dependent interactions have been more extensively studied during the last decade. Although the roles of carbohydrates in cellular functions are still poorly understood, the finding of carbohydrate-binding proteins in animal cells opened a great number of perspectives. 2. Animal lectins are associated with tumor progression, playing a key role in neoplastic cell interactions with endothelial cells and extracellular matrix glycoproteins such as laminin. 3. Here, we review the role of animal lectins in the migrating phenotype of neoplastic cells and normal cells such as T-lymphocytes.
Assuntos
Metabolismo dos Carboidratos , Matriz Extracelular/fisiologia , Animais , Antígenos Glicosídicos Associados a Tumores/metabolismo , Adesão Celular , Moléculas de Adesão Celular/metabolismo , Glicosilação , Humanos , Laminina/metabolismo , Lectinas/metabolismo , Ligação Proteica , Ratos , Linfócitos T/citologia , Timo/citologia , Células Tumorais CultivadasRESUMO
1. Carbohydrate-dependent interactions have been more extensively studied during the last decade. Althought the roles of carbohydrates in cellular functions are still poorly understood, the finding of carbohydrate-binding proteins in animal cells opened a great number of perspectives. 2. Animal lectins are associated with tumor progression, playing a key role in neoplastic cell interactions with endothelial cells and extracellular matrix glycoproteins such as laminin. 3. Here, we review the role of animal lectins in the migrating phenotype of neoplastic cells and normal cells such as T-lymphocytes