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1.
Mem Inst Oswaldo Cruz ; 110(5): 684-6, 2015 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-26270594

RESUMO

This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.


Assuntos
Antibacterianos/farmacologia , Aderência Bacteriana/efeitos dos fármacos , Eritromicina/farmacologia , Laminina/efeitos dos fármacos , Penicilinas/farmacologia , Streptococcus pyogenes/efeitos dos fármacos , Humanos , Testes de Sensibilidade Microbiana
2.
Mem. Inst. Oswaldo Cruz ; 110(5): 684-686, Aug. 2015. tab
Artigo em Inglês | LILACS | ID: lil-755893

RESUMO

This study investigated the possible relationship between the invasiveness of group A Streptococcus (GAS) strains and their abilities to adhere to laminin and assessed the effects of subinhibitory concentrations of penicillin and erythromycin on the ability of GAS to adhere to laminin. The adherence of noninvasive and highly invasive isolates of GAS to laminin was significantly higher than the adherence displayed by isolates of low invasiveness. Antibiotic treatment caused significant reductions in adherence to laminin in all three groups of strains. Penicillin was more successful in reducing the adherence abilities of the tested GAS strains than erythromycin.

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Assuntos
Humanos , Antibacterianos/farmacologia , Aderência Bacteriana/efeitos dos fármacos , Eritromicina/farmacologia , Laminina/efeitos dos fármacos , Penicilinas/farmacologia , Streptococcus pyogenes/efeitos dos fármacos , Testes de Sensibilidade Microbiana
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