RESUMO
BACKGROUND: metaplastic breast carcinoma (MBC) is uncommon, characterized by a heterogeneous mixture of histologic characteristics. OBJECTIVE: evaluate clinical and pathological characteristics in a population of patients with MBC in a reference center. MATERIALS AND METHODS: retrospective analysis of cases diagnosed with MBC at INCAN database from 2005-2011 was performed. Univariate assessment of clinical variables and their impact on disease free survival(DFS) and overall survival (OS) were evaluated. RESULTS: the records of 20 patients were identified. Median age was 49.5 (range: 33-75). Clinical stages at diagnosis were 6 I-II (30%) and 14 III-IV (70%). Three year OS was 52.1%. Patients< 40 years had an OS of 32.8 months vs. ≥ 40 years of 17.8 (p = 0.097). OS in stage I-II was 13.5 months vs. 23.3 months in III-IV (p = 0.99). Those who received neoadjuvant therapy had an OS of 26.57 vs. 14.36 in those who did not(p = 0.54). Those who received adjuvant therapy had an OS of 31.2 months vs. 11.15 in those who did not (p = 0.036). CONCLUSIONS: MBC has bad prognosis, nevertheless, age < 40 years and hormone receptor positivity, as well as adjuvant treatment seems to be factors that have an influence OS.
Assuntos
Neoplasias da Mama/patologia , Neoplasias da Mama/terapia , Adulto , Idoso , Intervalo Livre de Doença , Feminino , Humanos , Pessoa de Meia-Idade , PrognósticoRESUMO
BACKGROUND: Preterm birth is the most common cause of antepartum hospitalization. Currently little is known about neonatal morbidity in late preterm period. OBJECTIVE: To compare the short-term morbidity of infants born at term (37 0/7-41 0/7 weeks gestational age) of low-risk pregnancies with newborns in the late preterm period (34 0/7 to 36 6/7 weeks gestational age) of low-risk pregnancies. MATERIAL AND METHOD: retrospective study of births in the Hospital Metropolitano, Secretaria de Salud del Estado de Nuevo León (Mexico) between January 1, 2005 to December 31, 2007. The study included preterm births in the late period of low risk pregnancies in spontaneous labor, and three control cases matched at term of the same features for each of the late preterm. Neonatal complications were compared among those born in the late preterm period to term infants. RESULTS: Late preterm births accounted for 2.2% of births and had higher incidences of respiratory distress syndrome, longer hospital stay, jaundice requiring phototherapy and hypoglycemia than those born at term. CONCLUSION: Late preterm births are a vulnerable group with significant neonatal morbidity. It is necessary to design strategies to improve neonatal outcomes in late preterm group.