RESUMO

BACKGROUND: Vitamin D status has been associated with metabolic syndrome (MetSyn) and its components in different populations, but few studies have assessed this among Hispanics. The objective of this analysis was to assess such association in a clinic-based sample of Hispanic adults. METHODS: Medical records were reviewed retrospectively for the years 2005-2013. MetSyn was assessed using the revised NCEP-ATP III criteria. Vitamin D status was evaluated from reported serum 25(OH)D levels. A multivariable logistic regression model was used to assess the association between MetSyn risk and vitamin D status, controlling for important confounders. RESULTS: From 1379 medical records evaluated, 712 met the inclusion criteria. Most were females (62.6%), with a mean age of 53.8 ± 14.1 years, mean body mass index (BMI) of 30.1 ± 6.4 kg/m(2), and mean serum 25(OH)D levels of 24.4 ± 8.3 ng/mL. MetSyn was identified in 40.5% of the participants. Serum 25(OH)D levels in those with MetSyn (22.7 ± 8.0 ng/mL) were significantly lower compared to those without MetSyn (25.5 ± 8.4 ng/mL; P < 0.001). Serum 25(OH)D levels were inversely correlated to triglycerides, waist circumference, and fasting blood glucose (P < 0.05). In the multivariable logistic regression model, decreased serum 25(OH)D levels were associated with higher odds of MetSyn, even after adjusting for age, gender, BMI, and seasonality. CONCLUSION: In this clinic-based sample, the odds of MetSyn increased as serum 25(OH)D levels decreased. These results have important public health implications for developing recommendations directed to increase vitamin D status in this sample.

Assuntos

Síndrome Metabólica/sangue , Síndrome Metabólica/etnologia , Vitamina D/sangue , Adulto , Idoso , Glicemia/análise , Índice de Massa Corporal , Feminino , Hispânico ou Latino , Humanos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Estudos Retrospectivos , Luz Solar , Triglicerídeos/sangue , Estados Unidos , Circunferência da Cintura

RESUMO

Studies show that vitamin D status is associated to obesity but data in Hispanic individuals is scarce. The aim of this study was to assess the association between vitamin D status and obesity in a clinic-based sample in Puerto Rico. We hypothesized that subjects with a higher adiposity would have a lower vitamin D status. We extracted the following data from medical records of a private clinic: age, gender, serum 25(OH)D levels, weight, height, and waist circumference. Body mass index (BMI) (kg/m(2)) and waist-to-height ratio were calculated and categorized according to standard guidelines. Statistical analyses included analysis of covariance, Pearson correlations and χ(2) test. From 797 individuals (mean age 53.7 ± 15.4 years; 63.5% females), 35.6% were overweight and 43.7% obese. Mean 25(OH)D levels were 24.7 ± 8.7 ng/mL; 5.3% had levels <12 ng/mL, 30.6% had levels 12 to 20 ng/mL, and 43.5% had levels 21 to 30 ng/mL. Mean 25(OH)D levels were significantly higher in normal weight and overweight males compared to obese males (P < .05) and in overweight females compared to obese females (P < .05). Levels were also higher in those with low risk compared to high risk of waist circumference and waist-to-height ratio (P < .001). BMI, waist circumference, and waist-to-height ratio were inversely correlated to 25(OH)D levels (P < .001). A greater proportion of obese individuals (41.4%) were vitamin D deficient or insufficient compared to the normal weight (33.9%) and overweight individuals (30.3%) (P < .05). In conclusion, in this clinic-based sample of Puerto Rican adults, those with higher BMI, waist circumference, and waist-to-height ratio had a significantly lower vitamin D status.

Assuntos

Obesidade/epidemiologia , Sobrepeso/epidemiologia , Deficiência de Vitamina D/epidemiologia , Vitamina D/sangue , Adiposidade , Adulto , Idoso , Composição Corporal , Índice de Massa Corporal , Peso Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estado Nutricional , Obesidade/sangue , Sobrepeso/sangue , Porto Rico/epidemiologia , Estudos Retrospectivos , Fatores de Risco , Deficiência de Vitamina D/sangue , Circunferência da Cintura , Razão Cintura-Estatura

RESUMO

BACKGROUND: Vitamin D deficiency is a public health problem around the world. Diabetes has been associated with vitamin D deficiency. We aimed to examine the association between the vitamin D status and diabetes in a clinic based sample of Hispanic adults in Puerto Rico. METHODS: Demographics and laboratory test results for serum 25(OH)D, Fasting Blood Glucose (FBG), and Haemoglobin A1C (HbAlc) were extracted from medical records. Vitamin D status was classified as deficient (<12 ng/ml); inadequate (12-20 ng/ml); insufficient (21-29 ng/ml) and optimal (≥30 ng/ml) using serum 25(OH)D levels. RESULTS: A total of 716 records were included in the analyses. Most were females (63.3%), with mean age of 54.1±14.9 y, mean BMI 30.1±6.3 kg/m2 and mean serum 25(OH)D levels of 24.3±8.6 ng/ml. Most were classified as diabetics (41.1%). Those with diabetes had lower 25(OH)D levels compared to pre-diabetic and normal glucose status (p<0.05). Serum 25(OH) D levels were inversely correlated to FBG and HbA1c in the total sample and in men (p<0.05). After adjusting for age, gender, BMI and seasonality, there was a greater risk of diabetes, but not prediabetes, in those with serum 25(OH)D levels <30 ng/ml. This risk increased from 1.8 times in those with vitamin D insufficiency to 4.2 times in those with vitamin D deficiency (<12 ng/ml). CONCLUSION: Diabetes risk significantly increased as serum 25(OH)D levels decreased in this group of Hispanic adults, underscoring the importance of routinely screening high risk individuals for vitamin D deficiency and offer supplementation to normalize serum levels.