RESUMO
The occurrence of aflatoxin M1 (AFM1) in infant formulae commercialized in the metropolitan area of Monterrey (Nuevo León, Mexico) was determined by using immunoaffinity column clean-up followed by HPLC determination with fluorimetric detection. For this, 55 infant formula powders were classified in two groups, starter (49 samples) and follow-on (6 samples) formulae. Eleven of the evaluated samples (20%) presented values above the permissible limit set by the European Union for infant formulae (25 ng/L), ranging from 40 to 450 ng/L. The estimated daily intake (EDI) for AFM1 was determined employing the average body weight (bw) of the groups of age in the ranges of 0-6 and 6-12 months, and 1-2 years. The results evidenced high intake values, ranging from 1.56 to 14 ng/kg bw/day, depending on the group. Finally, with the EDI value, the carcinogenic risk index was determined, presenting a high risk for all the evaluated groups. Based on these results, it is a necessary extra effort by the regulatory agencies to reduce the AFM1 presence in infant formulae consumed in Mexico.
Assuntos
Aflatoxina M1/análise , Exposição Dietética/análise , Contaminação de Alimentos/análise , Fórmulas Infantis/análise , Peso Corporal , Pré-Escolar , Monitoramento Ambiental , Humanos , Lactente , Recém-Nascido , México , Neoplasias , Medição de RiscoRESUMO
OBJECTIVE: To evaluate the psychometric properties of the Spanish version of the short-form of the Children Perceived Oral Health Questionnaire aimed at assessing child's oral health-related quality of life of children aged 11-14 years (CPQ11-14 ). A secondary objective was to explore its screening qualities for evaluating oral health needs and immediate referral for treatment. METHODS: This cross-sectional study was conducted during August-December of 2011 in Monterrey, Mexico (n = 303 schoolchildren). The CPQ11-14 consisted of 16 items and 2 key questions. Dental caries was diagnosed by visual-tactile exam, and malocclusion by WHO index. We estimated Cronbach's alpha and Spearman's correlations and compared rank scores with the Mann-Whitney test. As we did not have a preestablished cutoff point score, we identified one with the best combination of sensitivity/specificity values using receiver operating characteristic curves. RESULTS: Internal consistency was 0.85. Correlation was 0.40 (P < 0.001) between CPQ11-14 scores and self-perceived oral health rating and 0.51 (P < 0.001) between CPQ11-14 score and general well-being rating (concurrent validity). The mean score was 11.6 ± 8.6 for children in need of oral care and 8.1 ± 7.2 for those not in need of oral care (P < 0.01; discriminating validity). Sensitivity was 79.4% and specificity 48.7%; the positive and negative predictive values were 81.6% and 45.2%, respectively. CONCLUSIONS: The Spanish version short-form CPQ11-14 registered acceptable psychometric properties. We were able to identify a cutoff point score with acceptable sensitivity and positive predictive value but still needs future validation before generalizing its use.