RESUMO
The prevalence and genotype distribution of human papillomavirus (HPV) provides the basis for designing HPV prevention programs. The prevalence rates of type-specific HPV and coinfections in samples of Mexican women were investigated in 822 women aged 18-87 years. HPV detection was performed using a Linear Array™ genotyping test. HPV infection was found in 12.4% of controls, 46.3% of those with cervical intraepithelial neoplasia 1, and 100% of those with cervical intraepithelial neoplasia 3 or cervical cancer. HPV 16 was the most prevalent type in all diagnosis groups. The HPV types most frequently found in cervical cancers were 16, 18, 45, 52, 58, and 39; HPV types 16, 62, 51, 84, 18, 53, and CP6108 were the most prevalent in control women. Considering HPV-positive samples only, coinfections occurred most often in controls (63%) and were less frequent in those with cervical cancer (26%). The most frequent viral types in coinfections with HPV 16 in control women were HPV 62, 51, and 84; in women with cervical cancers, HPV 18, 39, and 70 were most common. In conclusion, in addition to HPV types 16 and 18, types 45, 39, 58, 52, and 71 were found in cervical cancers in Mexican women (78%); among them, only 65% were attributable to HPV types 16 and 18. Therefore, it is necessary to consider these viral types in the design of new vaccines, and to determine whether certain HPV types coinfecting with HPV 16 in precursor lesions determine tumor progression or regression.
Assuntos
Genótipo , Papillomaviridae/classificação , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/epidemiologia , Infecções por Papillomavirus/virologia , Lesões Pré-Cancerosas/virologia , Displasia do Colo do Útero/virologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Coinfecção , Feminino , Técnicas de Genotipagem , Humanos , México/epidemiologia , Pessoa de Meia-Idade , Epidemiologia Molecular , Papillomaviridae/genética , Infecções por Papillomavirus/complicações , Prevalência , Adulto JovemRESUMO
BACKGROUND: Pregnancy during adolescence has been rising in the past years, and it is well known that preeclampsia affects teenagers, because maternal age and primigravida are risk factors. There are different ways and methods to predict preeclampsia, for example doppler velocimetry. OBJECTIVE: Determine S/D ratio of uterine artery in pregnant teenagers between 24-28 weeks and correlation with preeclampsia. MATERIAL AND METHOD: Observational study in 50 pregnant teenagers (14-19 years) obtaining uterine artery waveform at 24-28 weeks gestation recording S/D ratio. RESULTS: Sensitivity and specificity of 90% with a positive predictive value of 69.23% and negative predictive value of 97.3%. 13 patients had S/D ratio greater than 2.6, of which 5 had gestational hypertension, 3 with preeclampsia, 1 with Fetal Growth Restriction, 4 with normal pregnancy. Relative Risk was 25.62 (3.58-183.13) with odds ratio of 81.00 (6.83-2260.88) and p value 0.00002. CONCLUSION: analysis of uterine artery flow velocity waveforms is a method to predict preeclampsia.