Assuntos
Foliculite , Líquen Plano , Alopecia , Criança , Foliculite/diagnóstico , Humanos , Líquen Plano/diagnósticoAssuntos
Alopecia , Minoxidil , Sulfotransferases , Administração Oral , Alopecia/tratamento farmacológico , Alopecia/genética , Arilsulfotransferase/uso terapêutico , Feminino , Humanos , Minoxidil/uso terapêutico , Sulfotransferases/genética , Sulfotransferases/uso terapêutico , Resultado do TratamentoRESUMO
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lymphocytic scarring alopecia whose worldwide incidence is rising. Environmental triggers combined with genetic predisposition represent one of the current hypotheses in FFA aetiology. Familial clusters are opportunities to investigate the genetic basis of diseases. OBJECTIVES: Assess human leucocyte antigen (HLA) genetic variability in a Brazilian sample of a large familial cluster (six sisters and one daughter) with FFA, unnafected familiar members and sporadic cases of FFA. METHODS: We addressed the HLA-A, HLA-B, HLA-C, HLA-G and HLA-E genetic variability in this family and in seven sporadic FFA cases, comparing allele frequencies with those reported for the São Paulo State from Brazil. RESULTS: Two susceptibility haplotypes, C*17:01:01:02/B*42:01:01:01 and C*07:02:01:03/B*07:02:01:01, were identified among familial cases and also in sporadic cases. The first haplotype is rare among Brazilians, and it was not previously reported as being associated with FFA. Both alleles were found in some different unaffected familiars, what emphasizes the role of environmental triggers in disease development. HLA-A, HLA-G and HLA-E genes were not associated to familiar nor FFA sporadic cases. CONCLUSION: The identification of susceptibility haplotypes in FFA reinforces the genetic predisposition to the disease.
Assuntos
Alopecia , Líquen Plano , Alelos , Alopecia/genética , Brasil , Predisposição Genética para Doença , Haplótipos , Antígenos de Histocompatibilidade Classe II , HumanosRESUMO
OBJECTIVE: The objective of this study is to evaluate apoptosis in hair follicles of patients with female pattern hair loss (FPHL) and its association with follicular microinflammation. METHOD: Cross-sectional study involving 17 women with FPHL and five controls. Scalp skin samples were processed for HE and TUNEL assays. The variables were compared according to the categories of follicles (terminal versus miniaturized) and groups of patients (FPHL vs. controls). RESULTS: There was a higher apoptosis index among miniaturized follicles and among the test cases (P < 0.01). Microinflammation was prominent among miniaturized follicles, especially from FPHL (P = 0.02). In addition, a positive correlation between inflammatory infiltrate and apoptosis in miniaturized follicles (rS = 0.68; P < 0.01) was found. CONCLUSIONS: Apoptosis was prominent in hair follicles from the FPHL group, as well as in miniaturized ones. Moreover, it was also correlated with the inflammatory infiltrate, which suggests that inflammation can lead to apoptosis and play a role in the pathogenesis of follicle miniaturization.
Assuntos
Alopecia/patologia , Apoptose , Folículo Piloso/patologia , Inflamação/patologia , Estudos de Casos e Controles , Estudos Transversais , Feminino , Humanos , Marcação In Situ das Extremidades CortadasAssuntos
Humanos , Animais , Gatos , Cães , Raiva , Raiva/epidemiologia , Raiva/prevenção & controle , Vírus da Raiva , Cães , Gatos , Monitoramento EpidemiológicoAssuntos
Humanos , Animais , Gatos , Cães , Gatos , Cães , Monitoramento Epidemiológico , Raiva , Vírus da Raiva , Raiva/epidemiologia , Raiva/prevenção & controleRESUMO
Presentamos un caso de un paciente que sufre politraumatismo, incluyendo un trauma raquimedular con paraplejia con nivel motor T9 y traumatismo torácico predominante unilateral con atelectasia masiva del pulmón izquierdo, refractaria al tratamiento habitual, incluyendo ventilación mecánica con PEEP que respondió favorablemente a la aplicación de ventilación mecánica diferencial asincrónica. Este es un método si bien, excepcional, que puede ser de franca utilidad en la resolución terapéutica de patología pulmonar unilateral como en nuestro caso