RESUMO
This study evaluated the IS6110-RFLP patterns of 109 Mycobacterium tuberculosis isolates of patients with HIV cared for at a Brazilian university hospital. Thirteen clusters involving 35 (32.1%) individuals were identified. Nosocomial transmission was possible in 5 cases. Strategies to prevent M. tuberculosis transmission should be implemented in hospitals in developing countries.
Assuntos
Infecção Hospitalar , Países em Desenvolvimento , Infecções por HIV/complicações , Tuberculose Pulmonar/transmissão , Adulto , Brasil , DNA Bacteriano/análise , Feminino , Hospitais Universitários , Humanos , Controle de Infecções , Masculino , Polimorfismo de Fragmento de Restrição , Estudos Retrospectivos , Fatores de Risco , Tuberculose Pulmonar/genéticaRESUMO
The main species of mycobacteria isolated in 51 patients with acquired immunodeficiency syndrome (AIDS) admitted to the Clinical Hospital of UNICAMP (Teaching Hospital) in 1996, were studied retrospectively by recording the isolation site and signs of pathogenesis. Of these isolates, 31 (55 percent) were M.tuberculosis and 20 (45 percent) M.avium complex. Strains of M.tuberculosis isolated in 1996, 1997, and 1998, originating from 42 patients who had AIDS, were tested for susceptibillity to isoniazid and rifampicin. Of these, 34 (81 percent) were susceptible to both drugs tested, 4 (10 percent) were resistant to isoniazid and susceptible to rifampicin, 2 (5 percent) were susceptible to isoniazid and resistant to rifampicin, and 2 (5 percent) were resistant to both rifampicin and isoniazid. We conclude that, in Brazil, M.avium complex infections in AIDS are more commun that has been previously suggested; i.e., almost as frequent as M.tuberculosis infections. Approximately 20 percent of M.tuberculosis strains showed resistence to rifampicin and/or isomiazid. Further distribution of information regarding how to treat the disease in AIDS patients is needed.