RESUMO
OBJECTIVE: The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). METHOD: Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. RESULTS: Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. CONCLUSION: Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/etiologia , Epilepsia do Lobo Temporal/complicações , Função Executiva/fisiologia , Comportamento Exploratório/fisiologia , Aprendizagem em Labirinto/fisiologia , Animais , Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Modelos Animais de Doenças , Epilepsia do Lobo Temporal/fisiopatologia , Lateralidade Funcional/fisiologia , Masculino , Ratos , Ratos Wistar , Tempo de Reação/fisiologiaRESUMO
ABSTRACT Objective The present study aimed to investigate cognitive and behavioural changes consistent with attention deficit hyperactivity disorder (ADHD -like behavior in male Wistar rats with temporal lobe epilepsy (TLE). Method Male Wistar rats at 25 day of age were submitted to animal model of TLE by pilocarpine injection (350 mg/kg, ip) and a control group received saline 0.9%. The animals were continuously video monitored up to the end of experiments. The behavioural tests (open field, elevated plus maze and operant conditioning box) started from 60 days postnatal. Results Animals with TLE exhibited elevated locomotor activity, reduced level of anxiety-related behavior, impulsivity and impaired visuospatial working memory. Conclusion Taken as a whole, we concluded that animals with TLE exhibited some cognitive and behavioural changes consistent with ADHD-like behavior.
RESUMO Objetivo O presente estudo teve como objetivo investigar as alterações cognitivas e comportamentais consistentes com o comportament de transtorno de deficit de atenção e hiperatividade (TDAH) -like em ratos Wistar machos com epilepsia do lobo temporal (ELT). Método Ratos Wistar machos com 25 dias de vida foram submetidos a modelo animal de ELT pela injeção de pilocarpina (350 mg / kg, ip) e grupo controle recebeu salina 0,9%. Os animais foram monitorados continuamente por vídeo até ao final dos experimentos. Os testes comportamentais (campo aberto, labirinto em cruz elevado e caixa de condicionamento operante) começaram a partir de 60 dias pós-natal. Resultados Os animais com ELT exibiram aumento da atividade locomotora, redução do comportamento relacionado com a ansiedade, impulsividade e prejuízo da memória de trabalho visuospatial. Conclusão Em conjunto, concluímos que os animais com ELT apresentaram algumas alterações cognitivas e comportamentais consistentes com o comportamento TDAH-like.
Assuntos
Animais , Masculino , Ratos , Transtorno do Deficit de Atenção com Hiperatividade/etiologia , Aprendizagem em Labirinto/fisiologia , Epilepsia do Lobo Temporal/complicações , Comportamento Exploratório/fisiologia , Função Executiva/fisiologia , Tempo de Reação/fisiologia , Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Ratos Wistar , Modelos Animais de Doenças , Epilepsia do Lobo Temporal/fisiopatologia , Lateralidade Funcional/fisiologiaRESUMO
Previously, we demonstrated that male Wistar rats submitted to neonatal status epilepticus showed abnormal social behavior characterized by deficit in social discrimination and enhanced emotionality. Taking into account that early insult can produce different biological manifestations in a gender-dependent manner, we aimed to investigate the social behavior and anxiety-like behavior in female Wistar rats following early life seizures. Neonate female Wistar rats at 9 days postnatal were subject to pilocarpine-induced status epilepticus and the control received saline. Behavioral tests started from 60 days postnatal and were carried out only during the diestrus phase of the reproductive cycle. In sociability test experimental animals exhibited reduced motivation for social encounter and deficit in social discrimination. In open field and the elevated plus maze, experimental animals showed enhanced emotionality with no changes in basal locomotor activity. The results showed that female rats submitted to neonatal status epipepticus showed impaired social behavior, characterized by reduced motivation to novelty and deficit in social discrimination in addition to enhanced emotionality.