RESUMO
Objetivo: La tuberculosis es un grave problema de salud pública más acentuado en los países en desarrollo. De las manifestaciones extrapulmonares las que comprometen la cavidad abdominal están dentro de las menos frecuentes y se asocian con factores de predisposición específica. Se requiere un alto nivel de sospecha diagnóstica en el abordaje inicial de esta enfermedad. Presentamos el caso de un adulto masculino sin condiciones de predisposición quien consultó por un cuadro de dolor abdominal crónico y los estudios complementarios manifestaron una tuberculosis peritoneal con compromiso pleural sin síntomas respiratorios.
Objetive: Tuberculosis is a serious public health problem most prevalent in developing countries. Of extrapulmonary manifestations, those involving the abdominal cavity are among the least frequent and are associated with specific predisposing factors. A high level of diagnostic suspicion is required in the initial approach of this disease. We present the case of a male adult patient with no predisposing conditions who consulted for chronic abdominal pain. The complementary studies evidenced peritoneal tuberculosis with pleural involvement with no respiratory symptoms.
Assuntos
Humanos , Masculino , Adulto , Peritonite Tuberculosa , Dor Abdominal , Tuberculose Pleural , LaparoscopiaRESUMO
Antimicrobial peptides are small amphiphilic proteins found in animals and plants as essential components of the innate immune system and whose function is to control bacterial infectious activity. In order to accomplish their function, antimicrobial peptides use different mechanisms of action which have been deeply studied in view of their potential exploitation to treat antibiotic-resistant bacterial infections. One of the main mechanisms of action of these peptides is the disruption of the bacterial membrane through pore formation, which, in some cases, takes place via a monomer to oligomer cooperative transition. Previous studies have shown that lipid composition, and the presence of exogenous components, such as cholesterol in model membranes or carotenoids in bacteria, can affect the potency of distinct antimicrobial peptides. At the same time, considering the membrane as a two-dimensional material, it has been shown that membrane composition defines its mechanical properties which might be relevant in many membrane-related processes. Nevertheless, the correlation between the mechanical properties of the membrane and antimicrobial peptide potency has not been considered according to the importance it deserves. The relevance of these mechanical properties in membrane deformation due to peptide insertion is reviewed here for different types of pores in order to elucidate if indeed membrane composition affects antimicrobial peptide activity by modulation of the mechanical properties of the membrane. This would also provide a better understanding of the mechanisms used by bacteria to overcome antimicrobial peptide activity.