RESUMO
BACKGROUND: The prevalence of Lyme disease in Chile is unknown. AIM: To study the existence and epidemiology of Lyme disease in Chile. PATIENTS AND METHODS: One hundred eighteen patients with signs or symptoms suggestive of Lyme disease were studied. Antibodies against Borrelia burgdorferi were measured using ELISA and indirect immunofluorescence screening tests. Positive cases were confirmed with ELISA using a purified antigen and Western Blot analysis. Human biological samples and ticks were cultured in BSK-H medium. RESULTS: Five patients, three with dermatological manifestations and two with facial palsy and other neurological symptoms, had antibodies against Borrelia, measured by ELISA and indirect immunofluorescence. However the presence of IgM antibodies by ELISA using purified antigen, was confirmed in only one case. All sera and cerebrospinal fluids were negative on Western Blot Analysis. No plasma, skin, CSF or thick culture yielded Borrelia CONCLUSIONS: We could not confirm the existence of Lyme disease in Chile. Positive screening with negative confirmatory test suggests false positive non-specific reactivity or that local Borrelia are antigenically different compared to North American strains.
Assuntos
Doença de Lyme/diagnóstico , Adolescente , Adulto , Idoso , Animais , Grupo Borrelia Burgdorferi/imunologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Chile , Estudos Transversais , Cães , Ensaio de Imunoadsorção Enzimática , Técnica Indireta de Fluorescência para Anticorpo , Humanos , Doença de Lyme/imunologia , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Carrapatos/microbiologiaRESUMO
Se analizo la actividad de un nuevo antimicotico - tolciclato- en 56 pacientes portadores de pitiriasis versicolor, comparando su actividad con tolnaftato en una experiencia de doble ciego. Para este objeto, 28 pacientes fueron tratados con tolnaftato al 1% dos veces al dia y 28 pacientes recibieron tolciclato en solucion al 1% durante un periodo de cuatro semanas Los criterios de evaluacion tomaron en cuenta la negativizacion de los examenes micologicos descritos y la mejoria de la sintomatologia clinica (pigmentacion -descamacion y prurito). Los resultados obtenidos demuestran que a la segunda semana de tratamiento, el 92,5% de los pacientes que recibieron tolciclato tuvieron examenes micologicos negativos, en comparacion con el 64% de los pacientes tratados con tolnaftato.Esta diferencia resulta ser estadisticamente significativa (P < 0.05).Al termino de la investigacion todos los pacientes habian mejorado con ambos esquemas de tratamiento, demostrando tolciclato ser mas rapido en su accion.Ambos medicamentos fueron bien tolerados, y solamente se registro como efecto colateral prurito intenso en un paciente que recibio tolciclato y que obligo a suspender el tratamient