Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Int J Mol Sci ; 25(18)2024 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-39337657

RESUMO

Breast cancer (BC) is the leading cause of death from tumors in women worldwide, influenced by various factors, including genetics. The T allele of the single nucleotide variant (SNV) rs3025039 at position +936 of the VEGFA gene has been reported to affect the mRNA regulatory mechanisms, potentially altering VEGFA expression and increasing BC risk. This study aimed to investigate the association between rs3025039 and BC in Mexican women residing in Jalisco, Mexico. The study included 231 women with a confirmed diagnosis of BC and 201 healthy subjects as a reference group (RG). PCR-RFLP was employed for the genotyping of rs3025039, with the visualization of amplified products using polyacrylamide gel electrophoresis. Significant differences were observed in rs3025039 alleles and genotypes between BC cases and the RG (p = 0.0038). The frequency of the T allele and the CT genotype was higher in the BC group compared to the RG, with a significant difference (p = 0.0006). In conclusion, this research suggests that the SNV rs3025039 is associated with a higher risk of BC in Mexican women. These findings enhance our understanding of the genetic underpinnings of BC in this population, offering potential insights for future studies and interventions.


Assuntos
Neoplasias da Mama , Predisposição Genética para Doença , Genótipo , Polimorfismo de Nucleotídeo Único , Fator A de Crescimento do Endotélio Vascular , Humanos , Feminino , Neoplasias da Mama/genética , México/epidemiologia , Pessoa de Meia-Idade , Fator A de Crescimento do Endotélio Vascular/genética , Adulto , Fatores de Risco , Alelos , Estudos de Casos e Controles , Frequência do Gene , Idoso
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA