Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
1.
Braz. J. Pharm. Sci. (Online) ; 54(4): e17242, 2018. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1001571

RESUMO

The novel alkaloid, oleracimine, presented remarkable anti-inflammatory bioactivity, and therefore, its pharmacokinetics was investigated in rat plasma after intravenous and oral administration by using a rapid ultra-high-performance liquid chromatography (UHPLC) method with UV detection at 270 nm. The analysis was performed on a shim-pack ODS column (75 mm×2 mm, 1.6 µm particle size, Shimadzu, Japan) column using isocratic elution with a mobile phase consisting of methanol-water (62:38, v/v) within 3 min. The results indicated that oleracimine was rapidly distributed with Tmax for 11.7 min after oral administration, which presented the double-peak phenomenon in the pharmacokinetic profile with a higher oral absolute bioavailability of 55.1% ± 7.83%.


Assuntos
Animais , Masculino , Ratos , Farmacocinética , Cromatografia Líquida/métodos , Portulaca/efeitos adversos , Alcaloides/análise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA