RESUMO
A term infant had a life-threatening inferior venal caval thrombosis during the first 24 hours of life. The plasma from the infant and his mother was found to be resistant to activated protein C and to be heterozygous for the factor V mutation (FV Leiden) associated with this disorder. The presence of this hereditary disorder should be considered in infants with thrombosis and in infants with conditions predisposing them to thrombosis.
Assuntos
Recém-Nascido , Proteína C/análise , Tromboflebite/diagnóstico , Tromboflebite/genética , Antitrombina III , Fator V/análise , Fator V/genética , Amplificação de Genes , Genótipo , Humanos , Masculino , Mutagênese , Tempo de Tromboplastina Parcial , Linhagem , Reação em Cadeia da Polimerase , Tempo de ProtrombinaRESUMO
We describe a case of thrombocytopenia and deep venous thrombosis in a boy who received heparin to maintain patency of a central venous catheter. Measurement of the release of serotonin labeled with carbon 14 confirmed the presence of heparin-induced thrombocytopenia. Children receiving heparin therapy should be monitored for the possibility of heparin-induced thrombocytopenia.
Assuntos
Heparina/efeitos adversos , Trombocitopenia/induzido quimicamente , Tromboflebite/induzido quimicamente , Adolescente , Anastomose Cirúrgica , Plaquetas/imunologia , Cateterismo Venoso Central/instrumentação , Humanos , Isoanticorpos/análise , Perna (Membro)/irrigação sanguínea , Masculino , Contagem de Plaquetas/efeitos dos fármacos , Veia Subclávia , Trombose/induzido quimicamente , Valva Tricúspide/anormalidades , Valva Tricúspide/cirurgiaRESUMO
Women with severe liver disease often have amenorrhea that resolves as liver disease abates. We describe three patients with mild to moderate chronic liver disease and amenorrhea. In each case amenorrhea resolved when spironolactone therapy was discontinued. We suggest that spironolactone, an androgen inhibitor, may also cause reversible amenorrhea.