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SUMMARY Hypopituitarism is a rare clinical condition that can present as a partial or complete absence of pituitary hormones. Hypopituitarism is most commonly caused by a sellar or parasellar mass, particularly a tumor, and the gold standard for its differential diagnosis is magnetic resonance imaging (MRI). Intrasellar aneurysm is an unusual cause of hypopituitarism. Indeed, about 0.17% of all cases of hypopituitarism are due to intrasellar aneurysms. We report the case of a 72-year-old man who was admitted to the hospital due to gastrointestinal symptoms and malnourishment. Due to persistent hyponatremia and spontaneous hypoglycemia in laboratory findings, the examination of the hypothalamic-pituitary-adrenal axis was eventually initiated, and the patient was later diagnosed with an unruptured aneurysm of the ophthalmic segment of the right internal carotid artery with sellar extension as a cause of panhypopituitarism. A combined endovascular treatment was performed with stent-assisted coil embolization of the aneurysm, and the patient was prescribed oral hormonal therapy. At the 1-year follow-up visit, no improvement in pituitary function was observed, and a pituitary MRI showed complete aneurysm occlusion and partial empty sella with significantly decreased pituitary volume. Aneurysms of the internal carotid artery are rare and may be associated with hypopituitarism and delayed diagnosis due to their unusual clinical presentation. Endovascular procedures, such as coil embolization of the aneurysm, could be the treatment of choice in these patients. Persistent hypopituitarism may occur even after successful treatment of the aneurysm.
RESUMO
Abstract X chromosome STR typing has emerged recently as a powerful tool, complementary to autosomal STR typing, in solving complex forensic and missing person cases. Investigator® Argus X-12 is a commercial product that allows co-amplification of 12 X chromosomal markers belonging to four linkage groups (LGs). In this study, we analyzed by capillary electrophoresis blood samples from 100 females and 102 males from a population of northern Croatia. Statistical analysis included calculation of allele and haplotype frequencies, as well as forensic parameters. The most informative marker for the northern Croatia population was DXS10135 with PIC=0.9211 and a total of 27 alleles. The least polymorphic marker was DXS8378 with 6 alleles. The proportion of observed haplotypes from the number of possible haplotypes varied from 2.74-8.57% across all LGs, with LG1 being the most informative. Of the 11 tested world populations compared to the population of northern Croatia, significant differences in genetic distance (FST) were found for Greenlandic and all non-European populations. We found that all tested markers are in HWE and can thus be used for match probability calculation. Because of high combined power of discrimination in both men and women, Investigator® Argus X-12 is applicable for the northern Croatia population in routine forensic casework.
RESUMO
This paper examines the impact of the global economic crisis on revenues on all non-governmental sport organizations (sport NGOs) in Slovenia, as a small European economy. Five types of operating revenues of all sport NGOs from 2007 to 2010 have been analyzed. We found that the overall trend of sport NGOs revenues does not correspond exactly to the trends of the Slovenian economy. The greatest financial impacts were experienced in grassroots sport, while professional sport NGOs have increased their operating revenues, mostly due to increases of public revenues. The findings suggest that the true impact of the recession on Slovenian sport NGOs remains to be seen. We conclude that the ongoing recession will affect grassroots sport the least, while semi-professional and professional sport NGOs will be under financial threat. Because of the synergistic effects of different types of NGOs, this could affect the sustainability of Slovenian sport.
Este artigo analisa o impacto da crise econômica mundial sobre as receitas das organizações desportivas não governamentais (ONGs de esporte) na Eslovênia, como uma pequena economia europeia. Cinco tipos de receitas operacionais de todas as ONGs do esporte 2007-2010 foram analisados. Descobrimos que a tendência geral das receitas das ONGs do esporte não corresponde exatamente às tendências da economia eslovena. Os maiores impactos financeiros foram encontrados no esporte de base, enquanto as ONGs desportivas profissionais têm aumentado suas receitas operacionais principalmente devido ao aumento das receitas públicas. Os resultados sugerem que o verdadeiro impacto da recessão sobre as ONGs eslovenas desportivas continua a ser observado. Conclui-se que a recessão em curso afetará o esporte de base o mínimo, enquanto as ONGs de esportes semi-profissionais e profissionais estarão sob ameaça financeira. Por causa dos efeitos sinérgicos de diferentes tipos de ONGs isso poderá afetar a sustentabilidade do esporte esloveno.
Este artículo examina el impacto de la crisis económica global en los ingresos de las organizaciones deportivas no-gubernamentales (ONG's deportivas) en Eslovenia, como una pequeña economía europea. Han sido analizados cinco tipos de ingresos de explotación de todas las ONG's deportivas desde 2007 a 2010. Encontramos que la tendencia general de los ingresos de las ONG's deportivas no se corresponden con la tendencia de la economía eslovenia. El mayor impacto financiero fue experimentado en el deporte base, mientras que las ONG's deportivas profesionales han incrementado sus ingresos de explotación, generalmente debido al incremento de ingresos públicos. Los hallazgos sugieren que el auténtico impacto de la recesión en las ONG's deportivas eslovenias está aún por ver. Concluímos que la recesión en curso afectará lo mínimo al deporte base, mientras que las ONG's deportivas semiprofesionales y profesionales estarán económicamente amenazadas. Debido a los efectos sinérgicos de los diferentes tipos de ONG, esto podría afectar la sostenibilidad de los deportes de Eslovenia.