RESUMO

A lupin seed γ-conglutin-enriched preparation was tested in a glucose overload trial with both murine models and adult healthy volunteers. The results with rats showed a dose-dependent significant decrease of blood glucose concentration, which confirmed previous findings obtained with the purified protein. Moreover, three test-product doses equivalent to 630, 315, and 157.5 mg γ-conglutin, orally administered 30 min before the carbohydrate supply, showed a relevant hypoglycemic effect in human trials. Insulin concentrations were not significantly affected. The general hematic parameters did not change at all. This is the first report on the glucose-lowering effect of lupin γ-conglutin in human subjects.

Assuntos

Glicemia/metabolismo , Hipoglicemiantes/farmacologia , Lupinus/química , Extratos Vegetais/farmacologia , Proteínas de Plantas/farmacologia , Adulto , Animais , Relação Dose-Resposta a Droga , Feminino , Teste de Tolerância a Glucose , Humanos , Masculino , Extratos Vegetais/química , Ratos , Valores de Referência , Sementes