RESUMO

To assess the effects of a single supraphysiological postnatal administration of a progestogen on uterine glands in dogs, 10 females were randomly assigned to a medroxyprogesterone acetate 35 mg (MPA; n = 6) or placebo (n = 4) group within the first 24 h of birth. The safety of the treatment was also evaluated. A transient mild clitoris enlargement appeared in MPA-treated females. Microscopic postpubertal uterine assessment revealed the presence of uterine glands in all cases without significant differences in the area occupied by the glands per µm(2) of endometrium nor in the height of the uterine epithelium.

Assuntos

Epitélio/efeitos dos fármacos , Acetato de Medroxiprogesterona/farmacologia , Útero/efeitos dos fármacos , Animais , Animais Recém-Nascidos , Clitóris/efeitos dos fármacos , Cães , Feminino , Tamanho do Órgão/efeitos dos fármacos , Distribuição Aleatória , Maturidade Sexual/efeitos dos fármacos