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1.
Front Robot AI ; 11: 1331249, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38933083

RESUMO

Implementing and deploying advanced technologies are principal in improving manufacturing processes, signifying a transformative stride in the industrial sector. Computer vision plays a crucial innovation role during this technological advancement, demonstrating broad applicability and profound impact across various industrial operations. This pivotal technology is not merely an additive enhancement but a revolutionary approach that redefines quality control, automation, and operational efficiency parameters in manufacturing landscapes. By integrating computer vision, industries are positioned to optimize their current processes significantly and spearhead innovations that could set new standards for future industrial endeavors. However, the integration of computer vision in these contexts necessitates comprehensive training programs for operators, given this advanced system's complexity and abstract nature. Historically, training modalities have grappled with the complexities of understanding concepts as advanced as computer vision. Despite these challenges, computer vision has recently surged to the forefront across various disciplines, attributed to its versatility and superior performance, often matching or exceeding the capabilities of other established technologies. Nonetheless, there is a noticeable knowledge gap among students, particularly in comprehending the application of Artificial Intelligence (AI) within Computer Vision. This disconnect underscores the need for an educational paradigm transcending traditional theoretical instruction. Cultivating a more practical understanding of the symbiotic relationship between AI and computer vision is essential. To address this, the current work proposes a project-based instructional approach to bridge the educational divide. This methodology will enable students to engage directly with the practical aspects of computer vision applications within AI. By guiding students through a hands-on project, they will learn how to effectively utilize a dataset, train an object detection model, and implement it within a microcomputer infrastructure. This immersive experience is intended to bolster theoretical knowledge and provide a practical understanding of deploying AI techniques within computer vision. The main goal is to equip students with a robust skill set that translates into practical acumen, preparing a competent workforce to navigate and innovate in the complex landscape of Industry 4.0. This approach emphasizes the criticality of adapting educational strategies to meet the evolving demands of advanced technological infrastructures. It ensures that emerging professionals are adept at harnessing the potential of transformative tools like computer vision in industrial settings.

2.
Sci Rep ; 14(1): 11214, 2024 May 16.
Artigo em Inglês | MEDLINE | ID: mdl-38755242

RESUMO

The growing expansion of the manufacturing sector, particularly in Mexico, has revealed a spectrum of nearshoring opportunities yet is paralleled by a discernible void in educational tools for various stakeholders, such as engineers, students, and decision-makers. This paper introduces a state-of-the-art framework, incorporating virtual reality (VR) and artificial intelligence (AI) to metamorphose the pedagogy of advanced manufacturing systems. Through a case study focused on the design, production, and evaluation of a robotic platform, the framework endeavors to offer an exhaustive educational experience via an interactive VR environment, encapsulating (1) Robotic platform system design and modeling, enabling users to immerse themselves in the design and simulation of robotic platforms under varied conditions; (2) Virtual manufacturing company, presenting a detailed virtual manufacturing setup to enhance users' comprehension of manufacturing processes and systems, and problem-solving in realistic settings; and (3) Product evaluation, wherein users employ VR to meticulously assess the robotic platform, ensuring optimal functionality and customer satisfaction. This innovative framework melds theoretical acumen with practical application in advanced manufacturing, preparing entities to navigate Mexico's manufacturing sector's vibrant and competitive nearshoring landscape. It creates an immersive environment for understanding modern manufacturing challenges, fostering Mexico's manufacturing sector growth, and maximizing nearshoring opportunities for stakeholders.

3.
J Neural Eng ; 21(2)2024 04 26.
Artigo em Inglês | MEDLINE | ID: mdl-38626760

RESUMO

Objective. In recent years, electroencephalogram (EEG)-based brain-computer interfaces (BCIs) applied to inner speech classification have gathered attention for their potential to provide a communication channel for individuals with speech disabilities. However, existing methodologies for this task fall short in achieving acceptable accuracy for real-life implementation. This paper concentrated on exploring the possibility of using inter-trial coherence (ITC) as a feature extraction technique to enhance inner speech classification accuracy in EEG-based BCIs.Approach. To address the objective, this work presents a novel methodology that employs ITC for feature extraction within a complex Morlet time-frequency representation. The study involves a dataset comprising EEG recordings of four different words for ten subjects, with three recording sessions per subject. The extracted features are then classified using k-nearest-neighbors (kNNs) and support vector machine (SVM).Main results. The average classification accuracy achieved using the proposed methodology is 56.08% for kNN and 59.55% for SVM. These results demonstrate comparable or superior performance in comparison to previous works. The exploration of inter-trial phase coherence as a feature extraction technique proves promising for enhancing accuracy in inner speech classification within EEG-based BCIs.Significance. This study contributes to the advancement of EEG-based BCIs for inner speech classification by introducing a feature extraction methodology using ITC. The obtained results, on par or superior to previous works, highlight the potential significance of this approach in improving the accuracy of BCI systems. The exploration of this technique lays the groundwork for further research toward inner speech decoding.


Assuntos
Interfaces Cérebro-Computador , Eletroencefalografia , Fala , Humanos , Eletroencefalografia/métodos , Eletroencefalografia/classificação , Masculino , Fala/fisiologia , Feminino , Adulto , Máquina de Vetores de Suporte , Adulto Jovem , Reprodutibilidade dos Testes , Algoritmos
4.
Sensors (Basel) ; 23(23)2023 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-38067885

RESUMO

Obstructive Sleep Apnea (OSA) is a respiratory disorder characterized by frequent breathing pauses during sleep. The apnea-hypopnea index is a measure used to assess the severity of sleep apnea and the hourly rate of respiratory events. Despite numerous commercial devices available for apnea diagnosis and early detection, accessibility remains challenging for the general population, leading to lengthy wait times in sleep clinics. Consequently, research on monitoring and predicting OSA has surged. This comprehensive paper reviews devices, emphasizing distinctions among representative apnea devices and technologies for home detection of OSA. The collected articles are analyzed to present a clear discussion. Each article is evaluated according to diagnostic elements, the implemented automation level, and the derived level of evidence and quality rating. The findings indicate that the critical variables for monitoring sleep behavior include oxygen saturation (oximetry), body position, respiratory effort, and respiratory flow. Also, the prevalent trend is the development of level IV devices, measuring one or two signals and supported by prediction software. Noteworthy methods showcasing optimal results involve neural networks, deep learning, and regression modeling, achieving an accuracy of approximately 99%.


Assuntos
Síndromes da Apneia do Sono , Apneia Obstrutiva do Sono , Humanos , Polissonografia/métodos , Apneia Obstrutiva do Sono/diagnóstico , Sono , Oximetria/métodos
5.
Sensors (Basel) ; 23(22)2023 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-38005448

RESUMO

Current weather monitoring systems often remain out of reach for small-scale users and local communities due to their high costs and complexity. This paper addresses this significant issue by introducing a cost-effective, easy-to-use local weather station. Utilizing low-cost sensors, this weather station is a pivotal tool in making environmental monitoring more accessible and user-friendly, particularly for those with limited resources. It offers efficient in-site measurements of various environmental parameters, such as temperature, relative humidity, atmospheric pressure, carbon dioxide concentration, and particulate matter, including PM 1, PM 2.5, and PM 10. The findings demonstrate the station's capability to monitor these variables remotely and provide forecasts with a high degree of accuracy, displaying an error margin of just 0.67%. Furthermore, the station's use of the Autoregressive Integrated Moving Average (ARIMA) model enables short-term, reliable forecasts crucial for applications in agriculture, transportation, and air quality monitoring. Furthermore, the weather station's open-source nature significantly enhances environmental monitoring accessibility for smaller users and encourages broader public data sharing. With this approach, crucial in addressing climate change challenges, the station empowers communities to make informed decisions based on real-time data. In designing and developing this low-cost, efficient monitoring system, this work provides a valuable blueprint for future advancements in environmental technologies, emphasizing sustainability. The proposed automatic weather station not only offers an economical solution for environmental monitoring but also features a user-friendly interface for seamless data communication between the sensor platform and end users. This system ensures the transmission of data through various web-based platforms, catering to users with diverse technical backgrounds. Furthermore, by leveraging historical data through the ARIMA model, the station enhances its utility in providing short-term forecasts and supporting critical decision-making processes across different sectors.

7.
Life (Basel) ; 13(4)2023 Apr 17.
Artigo em Inglês | MEDLINE | ID: mdl-37109560

RESUMO

Motor neuron diseases (MNDs) are a group of chronic neurological disorders characterized by the progressive failure of the motor system. Currently, these disorders do not have a definitive treatment; therefore, it is of huge importance to propose new and more advanced diagnoses and treatment options for MNDs. Nowadays, artificial intelligence is being applied to solve several real-life problems in different areas, including healthcare. It has shown great potential to accelerate the understanding and management of many health disorders, including neurological ones. Therefore, the main objective of this work is to offer a review of the most important research that has been done on the application of artificial intelligence models for analyzing motor disorders. This review includes a general description of the most commonly used AI algorithms and their usage in MND diagnosis, prognosis, and treatment. Finally, we highlight the main issues that must be overcome to take full advantage of what AI can offer us when dealing with MNDs.

8.
Front Sociol ; 7: 946683, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36081574

RESUMO

Education around sexual and gender identities is highly important to understand diversity and prevent discrimination, violence, and even murder. Nevertheless, educational institutions around the world are lacking a curriculum that explicitly includes diversity and acknowledges the LGBTQ+ community, a minority that over the years has been facing consequences from this exclusion. This study presents a detailed description of the process applied to analyze the studies using a systematic mapping literature review, as well as the positive results found from those educational institutions that started their path to inclusion around sexual and gender diversities through their curricula. The research questions targeted in this work are: What is being taught in educational institutions regarding sexual and gender diversities? What are the approaches used inside the classrooms to teach sexual and gender diversities? Which students are receiving education regarding sexual and gender diversities? Is there a technological approach and/or tool used to teach sexual and gender diversities? After applying the filtering processes, 69 studies were selected from five different online libraries: ACM, DOAJ, Lens.org, SCOPUS, and SpringerLink. The conclusions made from the findings of this review are that those studies that do tackle concerns around the topic have proven to benefit the LGBTQ+ community, the education around sexual and gender diversities predominates within the healthcare field, there are a lack of studies around this topic in Latin American countries, and technological tools are minimally used during the teaching processes.

9.
Front Hum Neurosci ; 16: 867377, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35754778

RESUMO

Hands-free interfaces are essential to people with limited mobility for interacting with biomedical or electronic devices. However, there are not enough sensing platforms that quickly tailor the interface to these users with disabilities. Thus, this article proposes to create a sensing platform that could be used by patients with mobility impairments to manipulate electronic devices, thereby their independence will be increased. Hence, a new sensing scheme is developed by using three hands-free signals as inputs: voice commands, head movements, and eye gestures. These signals are obtained by using non-invasive sensors: a microphone for the speech commands, an accelerometer to detect inertial head movements, and an infrared oculography to register eye gestures. These signals are processed and received as the user's commands by an output unit, which provides several communication ports for sending control signals to other devices. The interaction methods are intuitive and could extend boundaries for people with disabilities to manipulate local or remote digital systems. As a study case, two volunteers with severe disabilities used the sensing platform to steer a power wheelchair. Participants performed 15 common skills for wheelchair users and their capacities were evaluated according to a standard test. By using the head control they obtained 93.3 and 86.6%, respectively for volunteers A and B; meanwhile, by using the voice control they obtained 63.3 and 66.6%, respectively. These results show that the end-users achieved high performance by developing most of the skills by using the head movements interface. On the contrary, the users were not able to develop most of the skills by using voice control. These results showed valuable information for tailoring the sensing platform according to the end-user needs.

10.
Front Hum Neurosci ; 16: 867281, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35558735

RESUMO

Currently, the most used method to measure brain activity under a non-invasive procedure is the electroencephalogram (EEG). This is because of its high temporal resolution, ease of use, and safety. These signals can be used under a Brain Computer Interface (BCI) framework, which can be implemented to provide a new communication channel to people that are unable to speak due to motor disabilities or other neurological diseases. Nevertheless, EEG-based BCI systems have presented challenges to be implemented in real life situations for imagined speech recognition due to the difficulty to interpret EEG signals because of their low signal-to-noise ratio (SNR). As consequence, in order to help the researcher make a wise decision when approaching this problem, we offer a review article that sums the main findings of the most relevant studies on this subject since 2009. This review focuses mainly on the pre-processing, feature extraction, and classification techniques used by several authors, as well as the target vocabulary. Furthermore, we propose ideas that may be useful for future work in order to achieve a practical application of EEG-based BCI systems toward imagined speech decoding.

11.
Sensors (Basel) ; 22(3)2022 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-35161783

RESUMO

The lack of interest of children at school is one of the biggest problems that Mexican education faces. Two important factors causing this lack of interest are the predominant methodology used in Mexican schools and the technology as a barrier for attention. The methodology that institutions have followed has become an issue because of its very traditional approach, with the professor giving all the theoretical material to the students while they listen and memorize the contents, and, if we add the issue of the growing access to technological devices for students, children carrying a phone are more likely to be distracted. This study aims to integrate technology through assistive robots as a beneficial tool for educators, in order to improve the attention span of students by making the learning process in multiple areas of the Mexican curriculum more dynamic, therefore obtaining better results. To prove this, four different approaches were implemented; three in elementary schools and one in higher education: the LEGO® robotic kit and the NAO robot for STEM (science, technology, engineering, and mathematics) teaching, the NAO robot for physical education (PE), and the PhantomX Hexapod, respectively. Each of these technological approaches was applied by considering both control and experimental groups, in order to compare the data and provide conclusions. Finally, this study proves that the attention span is indeed improved as a result of implementing robotic platforms during the teaching process, allowing the children to become more motivated during their PE class and become more proactive and retain more information during their STEM classes.


Assuntos
Procedimentos Cirúrgicos Robóticos , Robótica , Criança , Países Desenvolvidos , Humanos , Educação Física e Treinamento , Tecnologia
12.
Sensors (Basel) ; 21(23)2021 Nov 26.
Artigo em Inglês | MEDLINE | ID: mdl-34883868

RESUMO

Depression is a common mental illness characterized by sadness, lack of interest, or pleasure. According to the DSM-5, there are nine symptoms, from which an individual must present 4 or 5 in the last two weeks to fulfill the diagnosis criteria of depression. Nevertheless, the common methods that health care professionals use to assess and monitor depression symptoms are face-to-face questionnaires leading to time-consuming or expensive methods. On the other hand, smart homes can monitor householders' health through smart devices such as smartphones, wearables, cameras, or voice assistants connected to the home. Although the depression disorders at smart homes are commonly oriented to the senior sector, depression affects all of us. Therefore, even though an expert needs to diagnose the depression disorder, questionnaires as the PHQ-9 help spot any depressive symptomatology as a pre-diagnosis. Thus, this paper proposes a three-step framework; the first step assesses the nine questions to the end-user through ALEXA or a gamified HMI. Then, a fuzzy logic decision system considers three actions based on the nine responses. Finally, the last step considers these three actions: continue monitoring through Alexa and the HMI, suggest specialist referral, and mandatory specialist referral.


Assuntos
Questionário de Saúde do Paciente , Saúde da População , Depressão/diagnóstico , Manual Diagnóstico e Estatístico de Transtornos Mentais , Lógica Fuzzy , Humanos , Inquéritos e Questionários
13.
Pharmaceutics ; 13(12)2021 Dec 02.
Artigo em Inglês | MEDLINE | ID: mdl-34959338

RESUMO

Despite diagnostic and therapeutic advances, cardiometabolic disease remains the leading cause of death worldwide. Extracellular vesicles (EVs), which include exosomes and microvesicles, have gained particular interest because of their role in metabolic homeostasis and cardiovascular physiology. Indeed, EVs are recognized as critical mediators of intercellular communication in the cardiovascular system. Exosomes are naturally occurring nanocarriers that transfer biological information in the setting of metabolic abnormalities and cardiac dysfunction. The study of these EVs can increase our knowledge on the pathophysiological mechanisms of metabolic disorders and their cardiovascular complications. Because of their inherent properties and composition, exosomes have been proposed as diagnostic and prognostic biomarkers and therapeutics for specific targeting and drug delivery. Emerging fields of study explore the use exosomes as tools for gene therapy and as a cell-free alternative for regenerative medicine. Furthermore, innovative biomaterials can incorporate exosomes to enhance tissue regeneration and engineering. In this work, we summarize the most recent knowledge on the role of exosomes in cardiometabolic pathophysiology while highlighting their potential therapeutic applications.

14.
Sensors (Basel) ; 21(21)2021 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-34770657

RESUMO

Automobile security became an essential theme over the last years, and some automakers invested much money for collision avoidance systems, but personalization of their driving systems based on the user's behavior was not explored in detail. Furthermore, efficiency gains could be had with tailored systems. In Mexico, 80% of automobile accidents are caused by human beings; the remaining 20% are related to other issues such as mechanical problems. Thus, 80% represents a significant opportunity to improve safety and explore driving efficiency gains. Moreover, when driving aggressively, it could be connected with mental health as a post-traumatic stress disorder. This paper proposes a Tailored Collision Mitigation Braking System, which evaluates the driver's personality driving treats through signal detection theory to create a cognitive map that understands the driving personality of the driver. In this way, aggressive driving can be detected; the system is then trained to recognize the personality trait of the driver and select the appropriate stimuli to achieve the optimal driving output. As a result, when aggressive driving is detected continuously, an automatic alert could be sent to the health specialists regarding particular risky behavior linked with mental problems or drug consumption. Thus, the driving profile test could also be used as a detector for health problems.


Assuntos
Condução de Veículo , Automóveis , Acidentes de Trânsito , Humanos , México , Personalidade
15.
Sensors (Basel) ; 21(14)2021 Jul 07.
Artigo em Inglês | MEDLINE | ID: mdl-34300396

RESUMO

Nowadays, the concept of Industry 4.0 aims to improve factories' competitiveness. Usually, manufacturing production is guided by standards to segment and distribute its processes and implementations. However, industry 4.0 requires innovative proposals for disruptive technologies that engage the entire production process in factories, not just a partial improvement. One of these disruptive technologies is the Digital Twin (DT). This advanced virtual model runs in real-time and can predict, detect, and classify normal and abnormal operating conditions in factory processes. The Automation Pyramid (AP) is a conceptual element that enables the efficient distribution and connection of different actuators in enterprises, from the shop floor to the decision-making levels. When a DT is deployed into a manufacturing system, generally, the DT focuses on the low-level that is named field level, which includes the physical devices such as controllers, sensors, and so on. Thus, the partial automation based on the DT is accomplished, and the information between all manufacturing stages could be decremented. Hence, to achieve a complete improvement of the manufacturing system, all the automation pyramid levels must be included in the DT concept. An artificial intelligent management system could create an interconnection between them that can manage the information. As a result, this paper proposed a complete DT structure covering all automation pyramid stages using Artificial Intelligence (AI) to model each stage of the AP based on the Digital Twin concept. This work proposes a virtual model for each level of the traditional AP and the interactions among them to flow and control information efficiently. Therefore, the proposed model is a valuable tool in improving all levels of an industrial process. In addition, It is presented a case study where the DT concept for modular workstations underpins the development of technologies within the framework of the Automation Pyramid model is implemented into a didactic manufacturing system.


Assuntos
Inteligência Artificial , Indústrias , Automação , Tecnologia
16.
Sensors (Basel) ; 19(14)2019 Jul 14.
Artigo em Inglês | MEDLINE | ID: mdl-31337118

RESUMO

Artificial neural networks (ANN) are widely used to classify high non-linear systems by using a set of input/output data. Moreover, they are trained using several optimization methodologies and this paper presents a novel algorithm for training ANN through an earthquake optimization method. Usually, gradient optimization method is implemented for the training process, with perhaps the large number of iterations leading to slow convergence, and not always achieving the optimal solution. Since metaheuristic optimization methods deal with searching for weight values in a broad optimization space, the training computational effort is reduced and ensures an optimal solution. This work shows an efficient training process that is a suitable solution for detection of mobile phone usage while driving. The main advantage of training ANN using the Earthquake Algorithm (EA) lies in its versatility to search in a fine or aggressive way, which extends its field of application. Additionally, a basic example of a linear classification is illustrated using the proposal-training method, so the number of applications could be expanded to nano-sensors, such as reversible logic circuit synthesis in which a genetic algorithm had been implemented. The fine search is important for the studied logic gate emulation due to the small searching areas for the linear separation, also demonstrating the convergence capabilities of the algorithm. Experimental results validate the proposed method for smart mobile phone applications that also can be applied for optimization applications.

17.
J. bras. nefrol ; 41(2): 224-230, Apr.-June 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1012538

RESUMO

Abstract Introduction: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of phosphate binders (PB). Part of the reason for this challenge is poor adherence to treatment because of the high pill burden in this patient group. Objective: To assess the real-world effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus levels and determine the associated pill burden. Methods: A multicenter, quantitative, retrospective, before-after study was conducted with patients receiving online hemodiafiltration. Patients who switched to SO as a part of routine care were included in the study. PB treatment, number of pills, serum phosphorus levels, and intravenous iron medication and dosage were collected monthly during the six months of treatment with either PB or SO. Results: A total of 42 patients were included in the study. After switching from a PB to SO, the prescribed pills/day was reduced 67% from 6 pills/day to 2 pills/day (p < 0.001) and the frequency of pill intake was lowered from 3 times/day to 2 times/day (p < 0.001). During the treatment with SO, the proportion of patients with serum phosphorus ≤ 5.5 mg/dL increased from 33.3% at baseline to 45% after six months of treatment. Conclusion: During the six-month follow-up with SO, serum phosphorus levels were controlled with one third of the pills/day compared to other PB.


Resumo Introdução: A hiperfosfatemia é uma grave consequência da doença renal crônica associada a risco aumentado de doença cardiovascular. O controle dos níveis séricos de fósforo dos pacientes em diálise é um desafio que requer, na maioria dos casos, o uso de quelantes de fosfato (QF). Parte da dificuldade se deve à baixa adesão ao tratamento oriunda do grande número de medicamentos receitados para esse grupo de pacientes. Objetivo: Avaliar a real eficácia do oxihidróxido sucroférrico (OHS) no controle dos níveis séricos de fósforo e determinar a carga de comprimidos associada. Métodos: Estudo multicêntrico, quantitativo, retrospectivo, antes e depois conduzido com pacientes em hemodiafiltração on-line. Pacientes remanejados para OHS como parte dos cuidados de rotina foram incluídos no estudo. Tratamento com QF, número de comprimidos, níveis séricos de fósforo, reposição férrica endovenosa e dosagens foram registrados mensalmente durante seis meses de tratamento com QF ou OHS. Resultados: Foram incluídos 42 pacientes no estudo. Após a mudança de QF para OHS, o número de comprimidos prescritos por dia caiu em 67%, de seis para duas unidades diárias (p < 0,001). A frequência de ingestão de comprimidos caiu de três para duas vezes ao dia (p < 0,001). Durante o tratamento com OHS, o percentual de pacientes com fósforo sérico ≤ 5,5 mg/dL aumentou de 33,3% no início para 45% após seis meses de tratamento. Conclusão: Durante os seis meses de seguimento com OHS, os níveis séricos de fósforo foram controlados com um terço dos comprimidos por dia em relação aos tratamentos com outros QF.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Sacarose/uso terapêutico , Compostos Férricos/uso terapêutico , Hemodiafiltração , Hiperfosfatemia/tratamento farmacológico , Fósforo/sangue , Estudos Retrospectivos , Seguimentos , Resultado do Tratamento , Combinação de Medicamentos , Insuficiência Renal Crônica/complicações , Hiperfosfatemia/etiologia , Adesão à Medicação , Sevelamer/efeitos adversos , Sevelamer/uso terapêutico
18.
J Bras Nefrol ; 41(2): 224-230, 2019.
Artigo em Inglês, Português | MEDLINE | ID: mdl-30742699

RESUMO

INTRODUCTION: Hyperphosphatemia is a serious consequence of chronic kidney disease and has been associated with an increased risk for cardiovascular disease. Controlling serum phosphorus levels in patients on dialysis is a challenge for the clinicians and implies, in most cases, the use of phosphate binders (PB). Part of the reason for this challenge is poor adherence to treatment because of the high pill burden in this patient group. OBJECTIVE: To assess the real-world effectiveness of sucroferric oxyhydroxide (SO) in controlling serum phosphorus levels and determine the associated pill burden. METHODS: A multicenter, quantitative, retrospective, before-after study was conducted with patients receiving online hemodiafiltration. Patients who switched to SO as a part of routine care were included in the study. PB treatment, number of pills, serum phosphorus levels, and intravenous iron medication and dosage were collected monthly during the six months of treatment with either PB or SO. RESULTS: A total of 42 patients were included in the study. After switching from a PB to SO, the prescribed pills/day was reduced 67% from 6 pills/day to 2 pills/day (p < 0.001) and the frequency of pill intake was lowered from 3 times/day to 2 times/day (p < 0.001). During the treatment with SO, the proportion of patients with serum phosphorus ≤ 5.5 mg/dL increased from 33.3% at baseline to 45% after six months of treatment. CONCLUSION: During the six-month follow-up with SO, serum phosphorus levels were controlled with one third of the pills/day compared to other PB.


Assuntos
Compostos Férricos/uso terapêutico , Hemodiafiltração , Hiperfosfatemia/tratamento farmacológico , Sacarose/uso terapêutico , Adulto , Idoso , Combinação de Medicamentos , Feminino , Seguimentos , Humanos , Hiperfosfatemia/etiologia , Masculino , Adesão à Medicação , Pessoa de Meia-Idade , Fósforo/sangue , Insuficiência Renal Crônica/complicações , Estudos Retrospectivos , Sevelamer/efeitos adversos , Sevelamer/uso terapêutico , Resultado do Tratamento
19.
J Comput Chem ; 36(7): 478-92, 2015 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-25564969

RESUMO

Two of the most challenging problems that scientists and researchers face when they want to experiment with new cutting-edge algorithms are the time-consuming for encoding and the difficulties for linking them with other technologies and devices. In that sense, this article introduces the artificial organic networks toolkit for LabVIEW™ (AON-TL) from the implementation point of view. The toolkit is based on the framework provided by the artificial organic networks technique, giving it the potential to add new algorithms in the future based on this technique. Moreover, the toolkit inherits both the rapid prototyping and the easy-to-use characteristics of the LabVIEW™ software (e.g., graphical programming, transparent usage of other softwares and devices, built-in programming event-driven for user interfaces), to make it simple for the end-user. In fact, the article describes the global architecture of the toolkit, with particular emphasis in the software implementation of the so-called artificial hydrocarbon networks algorithm. Lastly, the article includes two case studies for engineering purposes (i.e., sensor characterization) and chemistry applications (i.e., blood-brain barrier partitioning data model) to show the usage of the toolkit and the potential scalability of the artificial organic networks technique.

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