RESUMO
BACKGROUND: Prevalence Candida infections have increased and oncologic patients have risk factors for contacting them. They are associated with a long hospital stay and high mortality rate. Candida resistance to antifungal drugs has been reported. OBJECTIVES: To determine the prevalence of Candida grown in cultures from oncologic patients. To identify isolated species and to determine C albicans sensitivity to antifungal drugs. MATERIAL AND METHODS: During one year, different species of Candida spp. were isolated. They were inoculated in API-C-20 at 48 h. and cultivated in RPMI-1640. RESULTS: Cultures of 5,820 patients were collected, 66.68% from outpatients and 33% from hospitalized patients. Candida spp grew in 394 Candida albicans obtained from 81 cultures was the most frequent species (46.3%). One hundred were susceptible to Amphotericin B, 63% to Fluconazol, 59% to Ketoconazol and 31% to Itraconazol. Candidemia accounted for 24.6% of bloodstream infections. CONCLUSIONS: C. albicans had significant resistance to imidazoles and 100% were susceptible to Amphotericin B. Identification of species and susceptibility of Candida infections a useful tools because of the high proportion of Candida non-albicans species (53.7%). Candidemia accounted for 5.076% of the infections.
Assuntos
Antifúngicos/farmacologia , Candida albicans/efeitos dos fármacos , Candidíase/epidemiologia , Hospitais Especializados , Humanos , Testes de Sensibilidade Microbiana , PrevalênciaRESUMO
With the aim to know the frequency of mycotic agents in patients with different types of cancer, samples were obtained from 81 patients from the Hospital de Oncología, Centro Médico Nacional Siglo XXI, IMSS from May 1995 through May 1996. In a conventional grouping seven (7) ambulatory patients were found in early stages, twenty seven (27) occasionally hospitalized patients were found in intermediate stage and forty seven (47) hospitalized patients in terminal stage of cancer. The different samples were processed through routine mycologycal methods and the following fungi species were isolated and identified: fifty four strains (58%) of Candida albicans followed by eleven strains (11.8%) of Candida tropicalis, six strains (6.45%) of Candida parapsilosis, five strains (5.37%) of Candida krusei, four strains (4.3%) of Candida humicola and five strains (5.37%) of Rodothorula rubra. From medical devices like catheter tips, drainage catheters (Pen rouse, Foley) and gallbladder catheters; four (4) strains of C. albicans, three (3) strains of Rodothorula rubra and two (2) strains of Aspergillus sp were isolated. Of the Candida non albicans it was relevant to find C. krusei more frequently than Rodothorula rubra, Aspergillus sp and Penicillum sp. The frequency of the presence of fungi increases commensurately to the advancement of the clincal stage of the cancer.