Assuntos
Ciclosporina/farmacocinética , Ciclosporina/uso terapêutico , Imunossupressores/farmacocinética , Imunossupressores/uso terapêutico , Transplante de Rim/imunologia , Administração Oral , Criança , Ciclosporina/administração & dosagem , Ciclosporina/sangue , Quimioterapia Combinada , Emulsões , Humanos , Imunossupressores/administração & dosagem , Imunossupressores/sangue , Transplante de Rim/fisiologia , Taxa de Depuração Metabólica , Análise de Regressão , Software , Fatores de TempoRESUMO
Wild rodents have been described as the most important hosts for Angiostrongylus costaricensis in Central America and southern Brazil. Sinantropic rodents apparently do not play a significant role as natural hosts. A search for natural infection failed to document worms in 14 mice captured in the house of a patient with diagnosis of abdominal angiostrongylosis and experimental infection of a "wild" Mus musculus strain and groups of albino swiss mice were carried out. Mortality was not significantly different and varied from 42% to 80% for Swiss mice and from 26% to 80% for "wild" mice. The high mortality of a "wild" M. musculus infected with A. costaricensis was very similar to what is observed with most laboratory mice strains. These data may be taken as indications that M. musculus is not a well adapted host for A. costaricensis, although susceptibility was apparently higher with "wild" populations of M. musculus as compared to Swiss strain.