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In many countries, there is an energy pricing policy that varies according to the time-of-use. In this context, it is financially advantageous for the industries to plan their production considering this policy. This article introduces a new bi-objective unrelated parallel machine scheduling problem with sequence-dependent setup times, in which the objectives are to minimize the makespan and the total energy cost. We propose a mixed-integer linear programming formulation based on the weighted sum method to obtain the Pareto front. We also developed an NSGA-II method to address large instances of the problem since the formulation cannot solve it in an acceptable computational time for decision-making. The results showed that the proposed NSGA-II is able to find a good approximation for the Pareto front when compared with the weighted sum method in small instances. Besides, in large instances, NSGA-II outperforms, with 95% confidence level, the MOGA and NSGA-I multi-objective techniques concerning the hypervolume and hierarchical cluster counting metrics. Thus, the proposed algorithm finds non-dominated solutions with good convergence, diversity, uniformity, and amplitude.

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To date, more than 2400 valid fish species have been recorded in the Amazon basin. However, some regions remain poorly documented. This is the case in the Beni basin and in particular in one of its main sub-basins, the Tuichi, an Andean foothills rivers flowing through the Madidi National Park in the Bolivian Amazonia. The knowledge of its ichthyological diversity is, however, essential for the management and protection of aquatic ecosystems, which are threatened by the development of infrastructures (dams, factories and cities), mining and deforestation. Environmental DNA (eDNA) has been relatively little used so far in the Amazon basin. We sampled eDNA from water in 34 sites in lakes and rivers in the Beni basin including 22 sites in the Tuichi sub-basin, during the dry season. To assess the biogeographical patterns of the amazonian ichthyofauna, we implemented a metabarcoding approach using two pairs of specific primers designed and developed in our laboratory to amplify two partially overlapping CO1 fragments, one of 185bp and another of 285bp. We detected 252 fish taxa (207 at species level) among which 57 are newly identified for the Beni watershed. Species compositions are significantly different between lakes and rivers but also between rivers according to their hydrographic rank and altitude. Furthermore, the diversity patterns are related to the different hydro-ecoregions through which the Tuichi flows. The eDNA approach makes it possible to identify and complete the inventory of the ichthyofauna in this still poorly documented Amazon basin. However, taxonomic identification remains constrained by the lack of reference barcodes in public databases and does not allow the assignment of all OTUs. Our results can be taken into account in conservation and management strategies and could serve as a baseline for future studies, including on other Andean tributaries.

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ABSTRACT: Mortatti, AL, Oliveira, RSCd, Pinto, JCBdL, Galvão-Coelho, NL, Almeida, RN, Aoki, MS, and Moreira, A. A congested match schedule alters internal match load and affects salivary immunoglobulin A concentration in youth soccer players. J Strength Cond Res 36(6): 1655-1659, 2022-The aim of this study was to analyze the effects of a congested match schedule (CMS) undertaken after a tapering week, on internal match load (IML) and salivary immunoglobulin A (SIgA) concentration in 12 youth soccer players (16.6 ± 0.5 years; 175 ± 8 cm; 65 ± 8 kg) who performed 4 official matches within a 4-day period. Internal match load was determined using the session-rating of perceived exertion method and the competitive strain (CS) and monotony index (MI) were also determined. Saliva sampling was conducted, before the last training day of a tapering week (training) preceding the CMS, 60 minutes before the first match (match-1), and 22 hours after match 4 (postmatch 4). Salivary immunoglobulin A was analyzed by ELISA. The results of the analysis of variance with repeated measures showed a significant difference for IML across the matches (p < 0.001). A significant reduction in SIgA was observed from prematch 1 to postmatch 4 (p = 0.019). Regarding the change in SIgA (ΔSIgA), 58.3% of the players presented values equal/higher than the minimal detectable change. A large within-individual correlation was observed between ΔSIgA and MI and CS (r = 0.71 and r = 0.72: p < 0.01, respectively). The current findings suggest that youth players participating in a CMS may present a decrease in mucosal immunity function. In addition, data suggest that the MI and CS may be used as valuable markers for monitoring competition load during CMS in youth soccer players.

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The study aim was to analyze the effects of successive matches on the internal match load, stress tolerance, salivary cortisol concentration and countermovement vertical jump height in twelve youth soccer players (16.6 ± 0.5 yr; 175 ± 8 cm; 65 ± 8 kg) who performed four official matches within a four day-period with a 24-h recovery interval between the matches. The internal match load, monotony index and competitive strain, as well as stress tolerance were examined. Saliva samples were collected and countermovement vertical jump height was assessed 60 min pre and 30 min post each match; delta of salivary cortisol and countermovement vertical jump height for each match were analyzed. Salivary cortisol was analyzed using an enzyme-linked immunosorbent assay. The results of ANOVA with repeated measures showed no differences between matches for the internal match load (p > 0.05). The scores of the monotony index and competitive strain were 4.3 (±2.3) and 8104 (±6795) arbitrary units, respectively. There was no difference for stress tolerance between matches (p > 0.05). Delta values of salivary cortisol were not different among the assessed matches (F(3,33) = 1.397, p = 0.351, η2: 0.09); however, delta of countermovement vertical jump height decreased from match 1 to match 4 (F(3,33) = 8.64, p < 0.001, η2: 0.44). The current findings suggest that participating in four successive matches, with 24-h of recovery in between, may not lead to changes in stress tolerance and salivary cortisol of youth players, but it may induce a decrease in players' jumping performance after the fourth match.

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abstract The study aimed to verify the correlation between resting heart rate variability (HRVrest) and endurance performance in female futsal players, as well as to evaluate the reliability of this parasympathetic autonomic marker. A total of 16 female futsal players (age: 22 ± 3 years; VO2max: 42.3 ± 2.0 ml.kg-1.min-1) were evaluated during the first week of preseason training. Vagal modulation was evaluated from the HRVrest (i.e., log-transformed root mean square of successive R-R interval differences - Ln-RMSSD) for two consecutive days, while endurance performance was evaluated by the Yo-Yo Intermittent Recovery Test, Level 1 (Yo-Yo IR1). Pearson correlation was used to analyze the relationship between the variables. Strong correlation between the HRVrest index and endurance performance (r = 0.643; p = 0.007). Reliability was tested through the intraclass correlation coefficient, coefficient of variation (CV), and Bland-Altman analysis of the agreement. Furthermore, acceptable repeatability of HRVrest, but with great inter-subject variability (ICC = 0.670, 95%CI = 0.056-0.885, CV = 15.8%). The current study demonstrated a strong correlation between Ln-RMSSD and endurance performance, and despite the acceptable values of intrasubject reliability, HRVrest presented high inter-individual variability in female futsal players.

resumo O objetivo do estudo foi verificar a correlação entre a variabilidade da frequência cardíaca de repouso (VFCRepouso) e o desempenho de resistência em jogadoras de futsal, bem como avaliar a confiabilidade do marcador parassimpático. No total, 16 jogadoras de futsal (idade: 22 ± 3 anos; VO2max: 42.3 ± 2.0 ml.kg-1.min-1) foram avaliadas durante a primeira semana de treinamento da pré-temporada. A modulação vagal foi avaliada a partir da VFC de repouso (isto é, raiz quadrada da média das diferenças sucessivas ao quadrado dos intervalos R-R adjacentes - Ln-RMSSD) por dois dias consecutivos, enquanto o desempenho da resistência foi avaliado pelo Yo-Yo Intermittent Recovery Test, Level 1 (Yo-Yo IR1). A correlação de Pearson foi utilizada para analisar a relação entre as variáveis. A confiabilidade foi testada através do coeficiente de correlação intraclasse, coeficiente de variação e análise de concordância de Bland-Altman. Observou-se uma forte correlação entre o índice de VFCrepouso e o desempenho de endurance (r = 0,643; p = 0,007). Por outro lado, repetibilidade aceitável dos índices de repouso vagal, mas com grande variabilidade interindividual (ICC = 0,670, IC = 0,056-0,885, CV = 15,8%). O presente estudo apresentou forte correlação entre Ln-RMSSD e desempenho de endurance, e mesmo com valores aceitáveis de confiabilidade intrasujeito, a VFC em repouso apresentou alta variabilidade interindividual em jogadoras de futsal.

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OBJETIVO: Investigar a prevalência de sonolência diurna excessiva (SDE) e os fatores associados em adolescentes de escolas militares. MÉTODOS: Participaram 466 adolescentes do ensino médio (15 a 17 anos) de ambos os sexos (230 homens). Os participantes foram entrevistados sobre as características sociodemográficas e sobre a duração de sono (semana e final de semana), adotando-se valores < 8 horas de sono como tempo insuficiente de sono. A SDE foi avaliada com a escala de sonolência de Epworth, na qual os adolescentes que obtivessem escores ≥ 10 apresentavam SDE. RESULTADOS: A prevalência geral de SDE foi de 34,1%. A média de horas de sono foi de 6,9 h (±1,85) em dias da semana e de 8,5 h (±1,96) nos fins de semana. Identificou-se que 60% dos adolescentes apresentaram baixa duração do sono semanal (p = 0,05). Observaram-se, no modelo final de regressão, maiores riscos de SDE nos indivíduos com baixa duração de sono (OR: 1,55; IC de 95%: 1,04-2,31) e que utilizavam o celular antes de dormir (OR: 4,30; IC de 95%: 2,00-9,23). CONCLUSÃO: A SDE foi fortemente associada ao uso de celular antes de dormir. Outros fatores associados são sono insuficiente e estudar em tempo integral. Medidas educacionais, administrativas e de saúde são necessárias para melhorar o sono em adolescentes.

OBJECTIVE: To investigate the prevalence of excessive daytime sleepiness (EDS) and associated factors in adolescents attending military schools. METHODS: 466 high school students (15-17 years old) of both sexes (230 men) participated. Participants were interviewed about sociodemographic characteristics and sleep duration (week and weekend), adopting values < 8 hours of sleep as insufficient sleep time. EDS was assessed with the Epworth Sleepiness Scale; where students with scores ≥ 10 had EDS. RESULTS: The overall prevalence of EDS was 34.1%. The mean for sleep hours was 6.9 h (±1,85) on weekdays and 8.5 h (±1.96) on weekends. It was identified that 60% of the adolescents presented short weekly sleep duration (p = 0.05). In the final regression model, higher EDS risks were observed in those subjects that had a short sleep duration (OR: 1.55; 95% CI: 1.04-2.31) and those that used the cell phone before bedtime (OR: 4.30; 95% CI: 2.00-9.23). CONCLUSION: EDS was strongly associated with cell phone use before bedtime. Other associated factors are insufficient sleep and studying full-time. Educational, administrative and health measures are needed to improve sleep in adolescents.

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O objetivo do estudo foi analisar o efeito da quantidade de balizas em jogos reduzidos no futsal (JRF's) sobre a carga interna e resposta afetiva. Participaram do estudo oito atletas adultas de futsal feminino, que treinavam regularmente cinco vezes por semana. Foram analisadas duas sessões de treinamento: 1) JRF1baliza 4 x 4 com uma baliza para cada equipe; 2) JRF3balizas4 x 4 com três balizas para cada equipe. A ordem dos JRF's foi escolhida de forma randomizada. Para análise da carga interna utilizou-se a escala CR 0-10 de percepção subjetiva de esforço (PSE) e para a resposta afetiva, utilizou-se a escala de sentimento (feeling scale). Utilizou-se o teste t pareado para análise da resposta psicofisiológica, considerando significativo um valor p < 0,05. Em nossos resultados os valores de P SE foram semelhantes entre os JRF's (JRF1baliza: 4,5 ± 1,7 vs. JRF3balizas: 4,4 ± 0,7, p > 0,05) da mesma fo rm a para a resposta afetiva (JRF1baliza: 0,2 ± 0,8 vs. JRF3balizas: 0,1 ± 1,0, p > 0,05), adicionalmente observou-se que os valores de PSE fixaram-se em "um pouco difícil" e a resposta afetiva permaneceu positiva durante ambos os JRF's. Em suma, conclui-se que os JRF1baliza e JRF3balizas obtiveram respostas semelhante nos marcadores psicofisiológicos (PSE e Afeto) em atletas adultas de futsal feminino...(AU)

The aim of this study was to analyze the effect of the number of goals in futsal small-sided games (SSG) on the internal load and affective response. Eight adult female futsal players regularly training five times a week participated in the study. Two training sessions were analyzed: 1) SSG1goal 4 x 4 with one goal for each team; 2) SSG3goal 4 x 4 with three goals for each team. The order of SSG was chosen in a randomized fashion. The CR 0-10 scale of rating of perceived exertion (RPE) was ch o sen to analyze internal load and for the affective response, the feeling scale was used. Paired t test was used t o analyze the psychophysiological response, considering a value p < 0.05. It was observ ed t hat t he RPE values were similar between the SSG (SSG1goal: 4.5 ± 1.7 vs. SSG3goal: 4.4 ± 0.7, p > 0.05) in the same way for affective response (SSG1goal: 0.2 ± 0.8 vs. SSG3goal: 0.1 ± 1.0, p > 0.05), it was further observed that the RPE values were set as "a little difficult" and the values of the Feeling Scale was p o sit iv e durin g bo th SSG. In summary, the SSG1goal and SSG3goal being performed in random order with seven days rest between them, obtained similar responses in the psychophysiological markers in adult female futsal players...(AU)

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Introducción La pielonefritis xantogranulomatosa (XGPN), es una enfermedad inflamatoria crónica del parénquima renal, de rara presentación en pediatría. Su etiología es multifactorial comenzando con un proceso obstructivo del tracto urinario por litiasis e infección hasta el daño renal crónico. Su diagnóstico se logra por sospecha clínica, estudio imagenológico e histopatológico, lo que require tratamiento definitivo en la mayoría con nefrectomía simple. Materiales y métodos Paciente masculino de 4 años de edad con infección de la vía urinaria y dilatación de pelvis y uréter causada por cálculos que genera un proceso inflamatorio crónico y destrucción del parénquima renal. Sin respuesta clínica a tratamiento antibiótico quien requirió manejo en unidad de cuidados intensivos y nefrectomía. Discusión Se presenta entre la cuarta a sexta década de vida, con reportes de caso en edad pediátrica. Cursa con fiebre, dolor abdominal y masa palpable. Puede presentar en cambio de cursar con leucocitosis, anemia y piuria. Estudio radiológico de XGPN se puede apreciar de forma focal o difusa. A la histopatología se evidencia necrosis tisular crónica con macrófagos espumosos en su interior entremezclados con células inflamatorias. El tratamiento definitivo requiere nefrectomía de unidad renal disfuncional. Conclusiones Se presenta el caso de paciente pediátrico con XGPN por obstrucción urinaria litiásica; entidad de baja frecuencia en ese grupo poblacional, requiere una adecuada correlación clínico-imagenológica e histológica para lograr el diagnóstico final y puede ser tratado con manejo médico y quirúrgico.

Introduction Xanthogranulomatous pyelonephritis (XGPN) is a chronic inflammatory disease of the renal parenchyma, rare in pediatrics. Etiology is multifactorial ranging from an obstructive urinary tract process through lithiasis and infection generating chronic kidney amage. Its diagnosis is achieved by clinical suspicion, imaging and histopathology, which requires definitive treatment in the majority with simple nephrectomy Materials and Methods A 4-year-old male patient with urinary tract infection and dilation of the pelvis and ureter caused by calculus that generate a chronic inflammatory process and destruction of the renal parenchyma. No clinical response to antibiotic treatment that required management and intensive care unit and nephrectomy. Discussion It occurs between the fourth and sixth decade of life, with case reports in pediatric age. Patients have fever, abdominal pain and palpable mass. They can occur with leukocytosis, anemia and pyuria. Radiological study of XGPN can be seen in focal or diffuse form. Histopathology looks a chronic tissue necrosis with foamy macrophages and inflammatory cells. Definitive treatment requires nephrectomy of damaged renal unit. Conclusions We report the case of pediatric patients with XGPN due to urinary obstruction of the lithiasis; Low frequency entity in this population group, requires an adequate clinical-imaging and histological correlation to achieve final diagnosis and can be treated with medical and surgical management.

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PURPOSE: It has been suggested that mitochondrial disease may be responsible for a substantial proportion of strokes of indetermined origin. We have preliminarily screened for MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) mutations in young patients with cryptogenic strokes. METHOD: The mitochondrial mutations A3243G and T3271C were investigated in 38 subjects aged less than 46 years. Group 1: 15 patients with cryptogenic strokes; Group 2: 3 patients with diagnosis of MELAS syndrome, including stroke-like episodes; Group 3: 20 healthy subjects. RESULTS: The A3243G mutation was absent in all subjects in Groups 1 and 3 but was present in all subjects in Group 2. CONCLUSION: Our results do not support screening for these mutations to diagnose oligosymptomatic forms of MELAS in cryptogenic strokes in the absence of other features of the syndrome. We suggest that clinical findings should guide mitochondrial genetic testing.

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PURPOSE: It has been suggested that mitochondrial disease may be responsible for a substantial proportion of strokes of indetermined origin. We have preliminarily screened for MELAS (mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes) mutations in young patients with cryptogenic strokes. METHOD: The mitochondrial mutations A3243G and T3271C were investigated in 38 subjects aged less than 46 years. Group 1: 15 patients with cryptogenic strokes; Group 2: 3 patients with diagnosis of MELAS syndrome, including stroke-like episodes; Group 3: 20 healthy subjects. RESULTS: The A3243G mutation was absent in all subjects in Groups 1 and 3 but was present in all subjects in Group 2. CONCLUSION: Our results do not support screening for these mutations to diagnose oligosymptomatic forms of MELAS in cryptogenic strokes in the absence of other features of the syndrome. We suggest that clinical findings should guide mitochondrial genetic testing.

PROPÓSITO: Foi sugerido que mitocondriopatias possam ser responsáveis por uma proporção substancial de acidentes vasculares cerebrais de etiologia indeterminada. Realizamos um estudo preliminar de pesquisa de mutações relacionadas à síndrome de MELAS (encefalomiopatia mitocondrial, acidose lática e episódios "stroke-like") em pacientes jovens com acidentes vasculares cerebrais criptogênicos. MÉTODO: As mutações mitocondriais A3243G e T3271C em 38 indivíduos com menos de 46 anos. Grupo 1: 15 pacientes com acidentes vasculares cerebrais criptogênicos; Grupo 2: 3 pacientes com diagnóstico de síndrome de MELAS, incluindo episódios "stroke-like"; Grupo 3: 20 voluntários saudáveis. RESULTADOS: A mutação A3243G esteve ausente em todos os indivíduos dos Grupos 1 e 3 mas esteve presente em todos os indivíduos do Grupo 2. CONCLUSÃO: Nossos resultados sugerem que não há utilidade em pesquisar estas mutações para diagnosticar formas oligossintomáticas de MELAS em acidentes vasculares cerebrais criptogênicos na ausência de características da síndrome. Sugerimos que o quadro clínico deva guiar a solicitação de pesquisas de mutações relacionadas a mitocondriopatias nestes pacientes.

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Realizamos un estudio descriptivo y transversal para evaluar a la ecografía abdominal como método de despistaje en 1751 trabajadores asintomáticos de la empresa Souther Perú Limited en 1997. Hubo un 10.85 por ciento de trabajadores con hallazgos ecográficos. Las caracteristicas que se asociaron de forma significativa a los trabajadores con hallazgos ecográficos fueron: edad media de 49.3 años y un indice de masa corporal promedio de 27.61 por ciento. El sexo y la procedencia no se asociaron con una mayor frecuencia de hallazgos ecográficos. Los hallazgos más importantes fueron 2 carcinomas renales en el 0.11por ciento de la población examinada y 1 carcinoma pancreático (0.06 por ciento); hubo hallazgos como la colelitiasis en un 5.54 por ciento.

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Realizamos un estudio descriptivo y transversal, original en el ámbito nacional, donde evaluamos a la ecografía abdominal como un método de despitaje; el estudio ecográfico se realizó en 1751 trabajadores asintomáticos de la empresa Southern Perú Limited durante el año de 1997. El uso de la ecografía como despitaje en estos trabajos fue evaluado con respecto a la frecuencia y variedad de hallazgos ecográficos encontrados, las características asociadas a los trabajadores con hallazgos ecográficos y los beneficios o problemas potenciales de esta intervención. Hubo un 10,85 por ciento de la población con hallazgos ecográficos. Los hallazgos más significativos fueron 2 carcinomas renales (0,11 por ciento) y 1 carcinoma pancreático (0,06 por ciento); Hubo otros hallazgos más comunes como la colelitiasis en un 5,54 por ciento. Las características que se asociaron de forma significativa a los trabajadores con hallazgos ecográficos fueron una edad promedio de 49,3 años y un índice de masa corporal promedio de 27,61 por ciento (obesidad leve). El sexo y la procedencia no se asociaron con una mayor frecuencia de hallazgos ecográficos. El estudio ecográfico del abdómen como un estudio de despitaje ha sido beneficioso en la empresa Southern Perú Limited y merece ser considerado por otros diferentes sistemas de salud, especialmente aquellos privados.

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Propoe-se aqui a ideia de que, na raiz, o pensamento de Lacan e o de Peirce sao analogos no que diz respeito a significacao. Entretanto, por causa de seu enquadramento historicamente binario, Lacan deriva conclusoes acerca do papel do sujeito que entra em conflito com a semiotica e com a propria logica ternaria que fundamenta o pensamento lacaniano e que seu binario superficial nao consegue de todo descobrir.

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