RESUMO
The inactivation of local and general effects of the Mapanare (Bothrops lanceolatus) venom by Opossum's (Didelphis marsupialis) serum fractions was tested using an in vivo assay and an in vitro preincubation experiment. A serum fraction of the Opossum serum has been obtained by immunochemical purification. It is only present in opossum's protective opossum serum fraction (F-0.1).
Assuntos
Bothrops , Venenos de Crotalídeos/antagonistas & inibidores , Gambás/sangue , Animais , Proteínas Sanguíneas/análise , Proteínas Sanguíneas/efeitos dos fármacos , Cromatografia DEAE-Celulose/métodos , Cromatografia em Gel/métodos , Venenos de Crotalídeos/toxicidade , Relação Dose-Resposta a Droga , Resistência a Medicamentos , Hemorragia/sangue , Hemorragia/induzido quimicamente , Camundongos , VenezuelaRESUMO
We are presenting the results obtained by endoscopic sclerotherapy with 80% alcohol in fifty-five patients with upper GI bleeding caused by esophageal varices, with or without active bleeding at the moment of the endoscopic study. We obtained control of bleeding in 83.64% with a recurrence of bleeding of 16.36% during the first 15 days. At the same period of time we obtained a 16.36% mortality rate. In the forty six patients that concluded sclerotherapy, decrease in size of the varices occurred in 89.79% and eradication was obtained in 6.11% of the patients. We observed three types of complications: esophageal ulcers in 100% of the cases which healed in a period of three weeks. Retrosternal pain of short duration, in 45.65%, this pain appears when the sclerosant substance is injected. Esophageal stenosis in 5.45% which were treated with dilatations. Our conclusion is that 80% alcohol is an effective and safe sclerosant substance in the management of acute bleeding of esophageal varices and in the prevention of the immediate recurrence, but has the disadvantage of a great number of local complications.
Assuntos
Varizes Esofágicas e Gástricas/terapia , Etanol/uso terapêutico , Hemorragia Gastrointestinal/terapia , Escleroterapia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Esofagoscopia , Etanol/química , Feminino , Hemostase Endoscópica , Humanos , Lactente , Recém-Nascido , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Soluções Esclerosantes/uso terapêutico , Escleroterapia/efeitos adversosAssuntos
Endoscopia , Hemorragia Gastrointestinal/diagnóstico , Adolescente , Adulto , Idoso , Anestésicos Locais/administração & dosagem , Criança , Diazepam/administração & dosagem , Emergências , Endoscopia/efeitos adversos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Parassimpatolíticos/administração & dosagem , Pré-MedicaçãoRESUMO
A comparative evaluation is made of patients with functional digestive diseases in an out-patient clinic of the Social Security of Barquisimeto. In the first group of patients a routine approach was followed while in the second group a brief biographic history is added adapting it to the circumstances of work that exist within this type of clinic. From the information obtained of the destiny of the patients of each group, it is evident that the total approach to the patient is of importance as the only mean possible for an adequate approximation to the patient and the proper management of the case. The problem is presented of the gastroenterologist, overwhelmed by the great technical progress, confronted by the destiny of the functional digestive patient in socialized medicine.