RESUMO

Primary lung paragangliomas are rare. They are 1-2% of the paragangliomas, and most of them occur in patients of 43-61 years. They clinically appear as solitary tumors and are in general asymptomatic. These tumors show a nesting pattern (Zellballen) of chief polygonal cells locked by fibrovascular trabeculae with subtenticular cells. The main cells have uniform nuclei with granular eosinophilic cytoplasm, and they are positive for neuroendocrinal markers (Neuron Specific Enolase, sinaptofisine and cromogranine A). Sustentacular cells are positive for protein S-100 and neurofibrilar protein. A differential diagnosis with the carcinoid tumor can be very difficult. The surgical treatment is mandatory , specially high blood pressure and the chances of malignization.

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RESUMO

Primary tumors of the small intestine are rare; 15-20% of the cases are extranodal lymphomas from B or T cells. Higher Incidence occurs in patients between 21 and 50 years. The clinical symptoms are pain, intestinal obstruction, diarrhea, bleeding or perforated peritonitis. In high-grade lymphomas, the cells are large and pleomorphic, with immunoblastic and plasmacytoid features, and immunopositive for alpha chain immunoglobulins. We reported the case of a 56-year-old patient presented with abdominal pain associated with intestinal perforation. Resections of a 9-centimetres-long segment in the small intestine was performed, which was covered by purulent plaques, with a perforation of 5 mm, surrounded by a greyish-white thick intestinal wall. It can be observed in the microscopy a proliferation of neoplastic cells arranged diffusely and with frequent mitosis. Large areas of immunoblastic and plasmacytoid configuration were evident. The immunomarcation was consistent with a lymphoma of large cells, immunophenotype B, with plasmacytoid development. We highlighted the clinical presentation like acute abdominal pain and its clinical and pathological characteristics, especially in the plasmacytoid development that should differ of the true plasmocytoma.

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RESUMO

Skin tissue from patients with Psoriasis was analyzed using HROM (High Resolution Optical Microscopy), studying epithelial differentiation and possible structural alterations of the queratinocytes. The samples were taken from 10 patients with histopathologic diagnosis of Psoriasis. This tissue samples where affixed with glutaraldehide buffer-collidine for 48 hours. Later processed with the HROM technique and colored with toluidine blue, metilene blue, basic Fuscine, and silver metenamine. The basal epithelial elements presented ovoid nucleus and most of them had prominent nucleolus. In 7 of the studied cases, the granulose stratus was absent, and thinner in the rest, with nucleus and nucleolus retention. At this level queratinocytes where observed with perinuclear anfofilia, as well as linfocitic and macrophagic infiltrate and union complex where elongated.

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RESUMO

La Psoriais se caracteriza por incremento del ciclo celular a nivel epidérmico, evidenciado a nivel histopatológico por un intensa hiperparaqueratosis, acantosis, papilomatosis e inflamación crónica. Materiales y métodos: Se estudió con microscopia óptica de alta resolución (MOAR), la epidermis de pacientes portadores de Psoriasis, analizando, la diferenciación epitelial y las posibelas alteraciones estructurales de los queratinocitos. Resultados: Los especímenes correspondieron a 10 pacientes con diagnóstico clínico e histopatológico de psoriasis. Las biopsias de piel fueron fijadas en solución de glutaraldehido buffer-collidina durante 48hs, procesados con la técnica para MOAR y coloreados con azul de toluidina, azul de metileno, fuscina básica y metenamina-plata. Los elementos epiteliales basales presentaban núcleos ovoideos, varios de ellos con nucleólos prominentes. En 7 de los casos estudiados el estrato granuloso estuvo ausente y en los 3 casos restantes observamos retención de núcleos y nucleólos. Conclusiones: Seobservaron queratinocitos con anfofilia e infiltrado linfocitario y de macrofagos.

Skin tissue from patients with Psoriasis was analyzed using HROM (High Resolution Optical Microscopy), studying epithelial differentiation and possible structural alterations of the queratinocytes. The samples were taken from 10 patients with histopathologic diagnosis of Psoriasis. This tissue samples where affixed with glutaraldehide buffer-collidine for 48 hours. Later processed with the HROM technique and colored with toluidine blue, metilene blue, basic Fuscine, and silver metenamine. The basal epithelial elements presented ovoid nucleus and most of them had prominent nucleolus. In 7 of the studied cases, the granulose stratus was absent, and thinner in the rest, with nucleus and nucleolus retention. At this level queratinocytes where observed with perinuclear anfofilia, as well as linfocitic and macrophagic infiltrate and union complex where elongated.

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RESUMO

Brown tumor (BT) is an uncommon condition that represents the terminal stage of the cystic osteitis fibrosa and have been increasingly reported in hyperparathyroidism secondary to renal failure, due to the increase of survival in patient with hemodialysis. The fine needle aspiration diagnosis is of great importance in the recognition of the BT, although it can be difficult to distinguish it of lesions as the aneurysmal bone cyst and giant-cell tumor. We describe the case of 20-year-old female with chronic renal failure undergoing hemodialysis during six years. Both x-rays and computer tomography revealed a tumor in head of right humerus and lytic images in scapula of the same side, clavicles and ribs. The patient was subjected to a fine needle aspiration biopsy of the tumor of humerus head and the sample was processed with the habitual technique of inclusion in paraffin and stained with hematoxilina and eosina. Histological preparations showed several multinucleate giant cells and spindly or fibrillary cells, feature that was pointed out as compatible, in a context of secondary hyperparathyroidism to chronic renal failure, with a BT. We consider that the radiological and tomographyc finds, besides the history of chronic renal failure with a long history of hemodialysis, were enough to link, with great approach, the histopathology with the diagnosis of BT.

El tumor pardo (TP) es una condición infrecuente que representa la fase terminal de la osteítis fibrosa quistica, habiéndose incrementado los reportes de tumores pardos en hiperparatiroidismos secundarios a falla renal. debido al aumento de supervivencia en pacientes dializados. El diagnóstico por aspiración con aguja fina es de gran importancia en el reconocimiento del TP. aunque puede ser dificil distinguirlo de lesiones como el quiste óseo aneurismático y el tumor de células gigantes. Presentamos el caso de una mujer de 20 años con insuficiencia renal crónica dializada durante seis años. que mostraba, con la tomografia computada y radiografia, un tumor en cabeza de húmero derecho e imágenes osteolíticas en homóplato homolateral, clavícula y costillas. Se realizó una biopsia por punción de la tumor ación de cabeza de húmero y la muestra fue procesada con la técnica habitual de inclusión en parafina y tinción con hematoxilina y eosina. Los preparados histológicos mostraron tejido constituido por abundantes células fusiformes y numerosas células gigantes multinucleadas, cuadro histopatológico que se señaló como compatible, en un contexto de hiperparatiroidismo secundario a insuficiencia renal crónica, con un TP.

Assuntos

RESUMO

Brown tumor (BT) is an uncommon condition that represents the terminal stage of the cystic osteitis fibrosa and have been increasingly reported in hyperparathyroidism secondary to renal failure, due to the increase of survival in patient with hemodialysis. The fine needle aspiration diagnosis is of great importance in the recognition of the BT, although it can be difficult to distinguish it of lesions as the aneurysmal bone cyst and giant-cell tumor. We describe the case of 20-year-old female with chronic renal failure undergoing hemodialysis during six years. Both x-rays and computer tomography revealed a tumor in head of right humerus and lytic images in scapula of the same side, clavicles and ribs. The patient was subjected to a fine needle aspiration biopsy of the tumor of humerus head and the sample was processed with the habitual technique of inclusion in paraffin and stained with hematoxilina and eosina. Histological preparations showed several multinucleate giant cells and spindly or fibrillary cells, feature that was pointed out as compatible, in a context of secondary hyperparathyroidism to chronic renal failure, with a BT. We consider that the radiological and tomographyc finds, besides the history of chronic renal failure with a long history of hemodialysis, were enough to link, with great approach, the histopathology with the diagnosis of BT.(AU)

El tumor pardo (TP) es una condición infrecuente que representa la fase terminal de la osteítis fibrosa quistica, habiéndose incrementado los reportes de tumores pardos en hiperparatiroidismos secundarios a falla renal. debido al aumento de supervivencia en pacientes dializados. El diagnóstico por aspiración con aguja fina es de gran importancia en el reconocimiento del TP. aunque puede ser dificil distinguirlo de lesiones como el quiste óseo aneurismático y el tumor de células gigantes. Presentamos el caso de una mujer de 20 años con insuficiencia renal crónica dializada durante seis años. que mostraba, con la tomografia computada y radiografia, un tumor en cabeza de húmero derecho e imágenes osteolíticas en homóplato homolateral, clavícula y costillas. Se realizó una biopsia por punción de la tumor ación de cabeza de húmero y la muestra fue procesada con la técnica habitual de inclusión en parafina y tinción con hematoxilina y eosina. Los preparados histológicos mostraron tejido constituido por abundantes células fusiformes y numerosas células gigantes multinucleadas, cuadro histopatológico que se señaló como compatible, en un contexto de hiperparatiroidismo secundario a insuficiencia renal crónica, con un TP.(AU)

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RESUMO

We describe a case of heterotopic mesenteric ossification presented in a 25 year-old male who underwent laparotomy for a fire-gun injury. Two weeks later he experienced small bowel obstruction and for this reason he has been operated five times with removal of segments of small bowel. Now, nine months later, he needs ileostomy to avoid another obstruction.

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Our purpose is to report two cases of fibromatosis in two women of 34 and 48 years old respectively that clinically appeared as a invasive breast carcinoma, particularly for the cutaneous retraction they showed. The histopathological diagnosis was done based on specimens studied with the common technique of paraffin embedding and Hematoxilin & Eosin staining. Both patients had firm poorly demarcated nodules with the histopathological pattern of classic fibromatosis. Mammary fibromatosis is an infrequent relapsing entity, not suspected in differential clinical diagnoses. The pathologist should bear it in mind, especially in frozen biopsies.

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RESUMO

Our purpose is to report two cases of fibromatosis in two women of 34 and 48 years old respectively that clinically appeared as a invasive breast carcinoma, particularly for the cutaneous retraction they showed. The histopathological diagnosis was done based on specimens studied with the common technique of paraffin embedding and Hematoxilin & Eosin staining. Both patients had firm poorly demarcated nodules with the histopathological pattern of classic fibromatosis. Mammary fibromatosis is an infrequent relapsing entity, not suspected in differential clinical diagnoses. The pathologist should bear it in mind, especially in frozen biopsies.

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Assuntos