RESUMO
Fluoxetine is a selective serotonin reuptake inhibitor that increases serotonin concentration in the central nervous system and modulates various systems, including the control of sympathetic outflow and the hypothalamus-pituitary-adrenal. However, it is not yet established whether fluoxetine can modulate the responses to stressors stimulants (physical or chemical) that trigger cortisol response in zebrafish. We demonstrate that fluoxetine blunts the response to physical stress, but not to chemical stress.
RESUMO
Amazonian peoples use traditional remedies prepared with Ptychopetalum olacoides (PO) roots for treating various age-related conditions. This study shows that a single intraperitoneally (i.p.) administration of Ptychopetalum olacoides ethanol extract (POEE, 50 and 100mg/kg) improved memory retrieval in step-down inhibitory avoidance (P Assuntos
Envelhecimento/efeitos dos fármacos
, Transtornos da Memória/tratamento farmacológico
, Memória/efeitos dos fármacos
, Olacaceae
, Envelhecimento/fisiologia
, Animais
, Masculino
, Memória/fisiologia
, Camundongos
, Extratos Vegetais/isolamento & purificação
, Extratos Vegetais/farmacologia
, Extratos Vegetais/uso terapêutico
, Raízes de Plantas
, Tempo de Reação/efeitos dos fármacos
, Tempo de Reação/fisiologia