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1.
Metabolism ; 45(9): 1174-8, 1996 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-8781307

RESUMO

Gastric emptying studies were performed on 11 nondiabetic Mexican-Americans and 11 nondiabetic non-Hispanic whites following ingestion of 450 mL beer. Plasma glucose, serum insulin, and serum alcohol levels were measured in the fasting state and at 7, 15, 30, 45, and 60 minutes following ingestion of the beer. The area under the gastric emptying curve was significantly larger for non-Hispanic whites compared with Mexican-Americans (P = .0492), indicating that Mexican-Americans had faster stomach emptying. Partial correlation coefficients (adjusted for ethnicity, gender, age, and body mass index [BMI]) showed the gastric half-emptying time was inversely related to the incremental levels of glucose (r = -.709, P = .0010) and alcohol (r = -.650, P = .0035). The faster the rate of gastric emptying of beer, the higher the glucose and alcohol levels. There were no significant correlations between insulin and the rate of gastric emptying. The caloric emptying rate for the beer was much more rapid than previously reported for other liquid meals.


Assuntos
Cerveja , Esvaziamento Gástrico , Americanos Mexicanos , População Branca , Adulto , Glicemia/análise , Etanol/sangue , Etnicidade , Feminino , Humanos , Insulina/sangue , Masculino , Valores de Referência
2.
Dig Dis Sci ; 40(3): 624-30, 1995 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-7895557

RESUMO

Mexican Americans, a group at high risk for type II diabetes mellitus, have higher postprandial insulin and glucose levels when compared to non-Hispanic whites. A rapid rate of gastric emptying contributes to an increased rate of nutrient absorption and subsequent greater elevation of postprandial glucose and insulin levels. A more rapid rate of gastric emptying and hyperinsulinemia have been observed in patients with recently diagnosed type II diabetes mellitus. In this study, we examined whether Mexican Americans have a more rapid rate of gastric emptying than non-Hispanic whites. Gastric emptying studies were performed on 32 nondiabetic Mexican Americans and on 31 nondiabetic non-Hispanic whites. The rate of gastric emptying following a liquid glucose meal was measured. Serum insulin, plasma glucose, and GIP levels were measured in fasting and postprandial blood samples collected at 15-min intervals for 2 hr. Adjusting for age, body mass index, and gender, the gastric half-emptying time of a glucose meal was significantly (P < 0.05) more rapid for the Mexican American subjects (56.5 +/- 3.4 min) compared to the non-Hispanic white subjects (66.4 +/- 3.5 min). Nondiabetic Mexican Americans empty a liquid glucose meal more rapidly from their stomachs than nondiabetic non-Hispanic whites. Rapid gastric emptying is associated with hyperinsulinemia as a normal physiologic response to increased nutrient availability. The rapid gastric emptying observed in nondiabetic Mexican Americans is associated with hyperinsulinemia and could be a contributing factor for the increased risk of obesity and type II diabetes in this population.


Assuntos
Diabetes Mellitus Tipo 2/etnologia , Esvaziamento Gástrico/fisiologia , Insulina/sangue , Americanos Mexicanos , Glicemia/análise , Feminino , Polipeptídeo Inibidor Gástrico/sangue , Glucose , Humanos , Hiperinsulinismo/etnologia , Incidência , Masculino , México/etnologia , Obesidade/etnologia , Fatores de Risco , Coloide de Enxofre Marcado com Tecnécio Tc 99m , População Branca
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