RESUMO
Disseminated histoplasmosis (DH) is the most current revelation mode of AIDS in French Guiana. We describe the clinical and paraclinical presentation of DH, diagnostic tools, evolution and factors associated with 1-year mortality in HIV-infected patients from western French Guiana. Microbiologically proven AIDS-related DH in Saint Laurent du Maroni's hospital between May 2002 and May 2012 were retrospectively included. Among the 82 patients included, 58 (71%) were male, 44 (53%) presented concurrent histoplasmosis and HIV diagnosis and 63 (80%) had a CD4 cell count under 50 cells µL(-1). Almost all patients had weight loss (97%) and fever (95%), while 84% had digestive symptoms (63% diarrhoea), 55% lymphadenopathy, and 49% respiratory symptoms. Documented and presumed locations of H. capsulatum var capsulatum (Hcc) concerned almost all organs, with a particular affinity for the bone marrow and the digestive system. Co-infections were associated in 65%. Following treatment initiation, 10 patients (13%) died within 1 month and 17 patients (25%) died within a year. DH is a polymorphous systemic mycosis with haematological and digestive tropism. Co-infections are frequent and mortality rate is high.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS , Histoplasma/isolamento & purificação , Histoplasmose , Infecções Oportunistas Relacionadas com a AIDS/diagnóstico , Infecções Oportunistas Relacionadas com a AIDS/mortalidade , Adulto , Medula Óssea/microbiologia , Contagem de Linfócito CD4 , Coinfecção , Diarreia , Feminino , Febre , Guiana Francesa , Trato Gastrointestinal/microbiologia , Histoplasmose/diagnóstico , Histoplasmose/mortalidade , Humanos , Doenças Linfáticas/microbiologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo , Redução de PesoRESUMO
This article concerns the reevaluation of the classification diagnosis of a Negro patient who had been diagnosed in Pittsburgh, Penna., in 1953 as lepromatous leprosy, which diagnosis had been accepted when he was admitted to the Federal Leprosarium at Carville, La. Actually, the condition was eather advanced borderline leprosy. The primary lesion on the right forearm had at first been thought by the´patient to be an insect bite, but it progressed and when biopsied six months later was reported to be "sarcoid" in nature, which presumably signifies "tuberculoid". When seen at the Aspinwall Veterans Administration Hospital after another eight months, it presented as a mother lesion of the aspect of a major tuberculoid lesion which had undergone borderline deterioration. On the face were many asymmetric small nodular and other lesions which evidently had arisen as an eruption in a tuberculoid reaction, but which had not - and never did - cause loss af the eyebrows. During the month of his first hospitalization there appeared a circinate lesion on the abdomen, described as similar to the one on the forearm. Histologically, the forearm lesion showed a complex picture with a predominance of lepromatous elements, containing an abundance of bacilli in most parts. In the deeper levels of the dermis the picture was definitely lepromatous, but in the main lesion mass in the upper levels the picture indicated that the basis had been a reactiobnal tuberculoid condition, although no distinct tuberculoid features remained. A significant feature of the principal biopsy specimen was the presence, in one end of the section, of a part of an "immune" area against which the active lesion ended abruptly. Such areas arise only by central healing of tuberculoid plaques, and never in lepromas. Although the patient left Carville against advice after only four months, to return to the Veterans Administration for outpatient treatment, his condition has cleared up. This favorable outcome is in accord with the relatively goood prognosis of borderline cases generally.