RESUMO

A simple methodology giving access to the metal-free corroles of trans-A2B type, 5,15-bis(pentafluorophenyl)-10-{3-[2-(pyridin-4-yl)vinyl]phenyl}corrole and 5,15-bis(pentafluorophenyl)-10-{4-[2-(pyridin-4-yl)vinyl]phenyl}corrole, and to the corresponding bipyridyl platinum(II) complexes is described. These new positional isomers were fully characterized and spectroscopic studies demonstrated the ability of Pt(II)-corrole complexes to establish non-covalent interactions with calf-thymus DNA (ct-DNA) and human serum albumin (HSA). Additionally, gel electrophoresis experiments demonstrated that Pt(II)-corrole complexes are able to bind plasmid pMT123 DNA, inducing alterations on its secondary structure.

Assuntos

2,2'-Dipiridil/química , DNA/química , Compostos Organoplatínicos/química , Porfirinas/química , Albumina Sérica/química , 2,2'-Dipiridil/síntese química , Animais , Bovinos , Eletroforese em Gel de Ágar , Humanos , Compostos Organoplatínicos/síntese química , Plasmídeos/química , Porfirinas/síntese química , Espectroscopia de Prótons por Ressonância Magnética , Espectrometria de Fluorescência