RESUMO
INTRODUCTION: Zoledronic acid or zo/edronate is a potent bisphosphonate that recently has been used in children with osteoporosis and osteogenesis imperfecta (01), so it could be an option in the treatment of children with this terrible disease that virtually condemns them to a life of pain and prostration. The aim of this study was to evaluate the clinical and biochemical conditions of pediatric patients with 01 before and after treatment with zo /edronate. RESULTS: We included 14 patients, median age six years (6 months to 14 years), eight (57.1 %) males and six (42 .9%) females, weight 19 kg (5.8-45 kg). According to the type of 01, six (42.9%) were type I, six (42.9%) type Ill, and two (14.2%) type IV The functional score (Bleck) previous to treatment was 4 (1-9) and 6 (2-9) after treatment (p = 0.001). Pain intensity prior to zo/edronate was 2 (1-9) and 0 (0-2) after (p = 0.008). Previous fractures five (1-15) and post-treatment one (0-2) (p = 0.001 ). There were no significant differences in calcium, phosphorus, alkaline phosphatase, and parathyroid hormone. CONCLUSIONS: Zoledronic acid decreases the number of bone fractures and pain in children with osteogenesis imperfect and improves functional status. The most common side effects were fever and bone pain within five days after the infusion,which disappear paracetamol. No adverse long-term effects such as hypocalcemia or hypoparathyroidism were reported.
Assuntos
Conservadores da Densidade Óssea/uso terapêutico , Difosfonatos/uso terapêutico , Imidazóis/uso terapêutico , Osteogênese Imperfeita/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Osteogênese Imperfeita/diagnóstico , Ácido ZoledrônicoAssuntos
Humanos , Malformações Arteriovenosas Intracranianas , Malformações Arteriovenosas Intracranianas/cirurgia , Malformações Arteriovenosas Intracranianas/diagnóstico , Malformações Arteriovenosas Intracranianas/epidemiologia , Malformações Arteriovenosas Intracranianas/história , Malformações Arteriovenosas Intracranianas/terapiaRESUMO
Instrumentación Segmentaria Espinal de Luque, con implante rectangular, fue utilizada como método de tratamiento en nueve pacientes, con historia de trauma cervical y diagnóstico de luxaciones, fracturas, y luxofracturas inestables. Tres de los casos seleccionados correspondieron respectivamente a luxación occipito-cervical, luxación de C7-T1 y fractura del tubérculo anterior del atlas asociado a fractura de odontoides. Los resultados fueron satisfactorios con fusión precoz, rehabilitación temprana y mejoría neurológica. La limitacioón de la movilidad de la columna cervical no fue incapacitante, excepto en el caso en que se involucraron los niveles occipital C1-C2
Assuntos
Humanos , Masculino , Adulto , Pessoa de Meia-Idade , Fusão Vertebral/instrumentação , Luxações Articulares/cirurgia , Traumatismos da Coluna Vertebral/cirurgia , Vértebras Cervicais/cirurgia , Fusão Vertebral/métodos , Resultado do TratamentoRESUMO
Se presenta el empleo del metodo de la minitrefinacion en forma aguda y sin sistema de drenaje cerrado, como tratamiento quirurgico en 44 casos de hematoma subdural cronico, 31 unilaterales y 13 bilaterales. Hubo mejoria completa en las horas o dias inmediatos al procedimiento en 38 (86%) pacientes. El hematoma se reprodujo en 3 (7%) personas. No hubo casos de infeccion ni de deterioro neurologico. Tampoco hubo muertes