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J Acquir Immune Defic Syndr (1988) ; 6(10): 1162-7, 1993 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-7692038

RESUMO

To study mother-to-child transmission of HTLV-I in Jamaica, we screened antenatal patients in Kingston, Jamaica, from 1983 to 1985. Of 2,329 women, 81 (3.5%) were HTLV-I seropositive. Two to three years later, 36 seropositive mothers were recontacted, and blood was drawn from them and their children. All sera were tested for HTLV-I antibodies, and mother's sera were additionally tested for HTLV-I whole-virus antibody titer, syncytium-inhibition neutralizing antibody titer, and titers to six synthetic peptides from the HTLV-I envelope glycoprotein gp46. Seventeen of 74 (23%) [95% confidence interval (CI) 15-34%] children were seropositive. HTLV-I transmission was associated with breast-feeding duration > 6 months [relative risk (RR) 3.2; CI 0.4-22.1], maternal age > 30 years (RR 2.8; CI 1.0-7.8), and higher maternal whole-virus antibody titer (RR 3.3; CI 1.3-8.5). After controlling for higher whole-virus antibody titer, transmission remained associated with higher titer of neutralizing antibody and higher titer of antibody to the peptide sp4a1, corresponding to amino acids 196-209 of the gp46 envelope glycoprotein. We conclude that mother-to-child transmission of HTLV-I in Jamaica is associated with longer duration of breast-feeding, older age, and higher HTLV-I antibody titer, in particular to a certain immunogenic portion of the gp46 envelope glycoprotein.


Assuntos
Produtos do Gene env/imunologia , Anticorpos Anti-HTLV-I/sangue , Antígenos HTLV-I/imunologia , Infecções por HTLV-I/transmissão , Proteínas Oncogênicas de Retroviridae/imunologia , Adolescente , Aleitamento Materno , Criança , Pré-Escolar , Epitopos/imunologia , Feminino , Infecções por HTLV-I/epidemiologia , Infecções por HTLV-I/imunologia , Humanos , Lactente , Recém-Nascido , Jamaica/epidemiologia , Idade Materna , Gravidez , Fatores de Risco
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