RESUMO
OBJECTIVES: This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. MATERIAL AND METHODS: One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples. RESULTS: Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group. CONCLUSIONS: Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.
Assuntos
Bactérias/isolamento & purificação , Cirurgia Bariátrica , Helicobacter pylori/isolamento & purificação , Boca/microbiologia , Obesidade/microbiologia , Estômago/microbiologia , Adolescente , Adulto , Idoso , Análise de Variância , Biópsia , Índice de Massa Corporal , Estudos Transversais , Placa Dentária/microbiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade/cirurgia , Índice Periodontal , Periodontite/microbiologia , Reação em Cadeia da Polimerase , Valores de Referência , Saliva/microbiologia , Estatísticas não Paramétricas , Adulto JovemRESUMO
ABSTRACT Objectives This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. Material and Methods One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples. Results Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group. Conclusions Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Estômago/microbiologia , Bactérias/isolamento & purificação , Helicobacter pylori/isolamento & purificação , Cirurgia Bariátrica , Boca/microbiologia , Obesidade/microbiologia , Periodontite/microbiologia , Valores de Referência , Saliva/microbiologia , Biópsia , Índice de Massa Corporal , Índice Periodontal , Reação em Cadeia da Polimerase , Estudos Transversais , Análise de Variância , Estatísticas não Paramétricas , Placa Dentária/microbiologia , Obesidade/cirurgiaRESUMO
This study evaluated the association between body mass index (BMI) and periodontal condition in a population of Brazilian women. A hospital convenience sample of 594 eligible women was recruited from a women's health reference center of Belo Horizonte, Brazil. Four groups were formed considering BMI levels: BMI normal group (n = 352), overweight (n = 54), obesity level I (n = 48), obesity level II (n = 56), and obesity level III (n = 74). Full-mouth periodontal examination was performed and biological, demographic, and behavioral risk variables were evaluated. Obese and overweight women showed statistically significant differences in bleeding on probing, probing depth and clinical attachment level ≥ 4 mm, and frequency of periodontitis (p < 0.05) compared to women showing normal BMI. The final multivariate model for the occurrence of periodontitis revealed that obesity groups were significantly associated with periodontitis. In addition, age (25-45), smoking, diabetes, and hypertension remained significantly associated with the occurrence of periodontitis (p < 0.05). Periodontitis was positively associated with obesity, and this association was more evident as obesity levels increases. These findings indicate the need for early diagnosis and the inclusion of periodontal care in health care programs for obese women.
Assuntos
Índice de Massa Corporal , Obesidade/complicações , Periodontite/complicações , Adulto , Fatores Etários , Brasil , Complicações do Diabetes , Feminino , Humanos , Hipertensão/complicações , Pessoa de Meia-Idade , Análise Multivariada , Higiene Bucal/estatística & dados numéricos , Sobrepeso/complicações , Fatores de Risco , Fumar/efeitos adversos , Fatores SocioeconômicosRESUMO
BACKGROUND: Recent studies have shown that being overweight or obese is associated with a higher risk of periodontitis. However, the literature offers an insufficient number of published reports regarding the effect of bariatric surgery on oral health. As such, the present study aims to determine the association between periodontal status and being overweight/obese in prebariatric and postbariatric surgery populations of Brazil. METHODS: Three hundred forty-five participants between 18 and 60 years of age, from both sexes, were grouped according to prebariatric or postbariatric surgery and underwent a complete periodontal examination. Biologic, demographic, and behavioral variables were analyzed in a Poisson regression model. RESULTS: Considering the timing of bariatric surgery, the sample was divided into three groups: PRE-OP (preoperative, n = 133), POS-OP1 (postoperative ≤6 months, n = 72), and POS-OP2 (post-surgery >6 months, n = 140). Regardless of the type of surgery (PRE-OP, POS-OP1, POS-OP2), the prevalence of periodontitis proved to be high (81.45%). There was a statistically significant difference in the prevalence of periodontitis among the PRE-OP, POS-OP1, and POS-OP2 groups (P = 0.040). In the Poisson regression model, after adjusting for biologic, demographic, and behavioral risk variables, only bleeding on probing remained significantly associated with the prevalence of periodontitis (P <0.001). CONCLUSION: Differences in periodontal condition were observed in individuals at different times of the bariatric surgery, showing a high prevalence of periodontitis in both preoperative and postoperative follow-up.
Assuntos
Cirurgia Bariátrica/estatística & dados numéricos , Obesidade/epidemiologia , Periodontite/epidemiologia , Adolescente , Adulto , Estatura , Índice de Massa Corporal , Peso Corporal , Brasil/epidemiologia , Estudos Transversais , Complicações do Diabetes/epidemiologia , Dislipidemias/epidemiologia , Escolaridade , Feminino , Seguimentos , Hemorragia Gengival/epidemiologia , Humanos , Hipertensão/epidemiologia , Renda , Masculino , Estado Civil , Pessoa de Meia-Idade , Obesidade/cirurgia , Sobrepeso/epidemiologia , Sobrepeso/cirurgia , Índice Periodontal , Prevalência , Fatores de Risco , Fumar/epidemiologia , Adulto JovemRESUMO
A obesidade é uma doença crônica e multifatorial, considerada um problema de saúde pública crescente em todo o mundo. Recentemente, a obesidade tem sido associada à doença periodontal, tanto em susceptibilidade como em gravidade. Entretanto, estes estudos são escassos e ainda não foi reportada a influência da obesidade mórbida frente `adoença periodontal e, particulamente, sobre patógenos periodontais em boca e estômago. Nesse sentido, 722 indivíduos elegíveis participaram dos estudos, sendo 370 indivíduos em tratamento cirúrgico de obesidade em centro de referência em Belo Horizonte, Minas Gerais, Brasil e 352 indivíduos acompanhantes desses pacientes. Desta população, 594 mulheres constituíram a amostra para o estudo caso-controle sobre obesidade, 345 indivíduos constituíram a amostra para o estudo transversal em obesos mórbidos candidatos e submetidos à cirurgia bariátrica e, entre estes, 154 participaram do estudo microbiológico...
Assuntos
Humanos , Masculino , Feminino , Cirurgia Bariátrica/efeitos adversos , Doenças Periodontais/complicações , Obesidade/complicações , Periodontite/complicações , Índice de Massa Corporal , Obesidade Mórbida/complicaçõesRESUMO
Apesar da frequente queixa de halitose entre indivíduos submetidos à cirurgia bariátrica, nenhum estudo foi feito a respeito da relação dessa queixa com o aumento real da concentração de compostos sufurados voláteis (CSV) na cavidade bucal. O objetivo desse estudo foi avaliar e comparar a autoavaliação do hálito entre 31 indivíduos obesos (controle) e 31 indivíduos submetidos à cirurgia bariátrica (caso), em tratamento no ambulatório de obesidade da Santa Casa de Belo Horizonte, e a sua relação com a concentração de CSV na cavidade bucal. Além disso, pretendeu-se verificar o impacto dessa autoavaliação na qualidade de vida desses indivíduos. A halitometria foi realizada pelos próprios participantes através de uma EVA(escala visual analógica) e com o auxílio de um monitor portátil de enxofre. Para avaliação do impacto na qualidade de vida foi utilizado um questionário com quatorze questões estruturadas (QIQV). Os resultados mostraram não haver diferença significativa entre a autoavaliação do hálito (p = 0,09) e as concentrações médias de CSV nos grupos caso e controle (p = 0,48). Houve correlação significativa entre esses dois resultados apenas no grupo caso (p =0,0173). Quanto ao QIQV, também não houve diferença significativa entre a média da sua pontuação final nos dois grupos. Nenhuma correlação foi encontrada entre EVA e QIQV, nos grupos caso (rs = 0.29, p = 0,10) e controle (rs =0,15, p = 0,38). Conclui-se que a queixa de halitose entre os indivíduos submetidos à cirurgia bariátrica não é mais frequente que entre os indivíduos obesos a espera dessa cirurgia.
Although the frequent complaint of halitosis among individuals undergoing bariatric surgery, any study has beenmade about the relationship of these complain with a real increase in volatile sulphur compounds (VSC) in oral cavity.That way, the purposes of this study was access and compare the selfestimation of halitosis and their relationship with VSC concentration in oral cavity of 31 obese individuals(control) and 31 individuals undergoing bariatric surgery (case). Additionally, the intent was asses the impact of halitosis in quality of life. All participants where treating in obesity ambulatory of Santa Casa Hospital in Belo Horizonte Brazil The halitometria was realized by the own participants by a VAS (Visual Analogical Scale)) and by a portable sulphide monitor. The impact of halitosis on quality of life was measured by a questionnaire with fourteen structurequestions (QIQV). The outcomes showed no significative difference among the self-assessment of the breath (p =0,09) and the concentrations of CSV on the case and control groups (p = 0,48). There was a correlation among those two results only into the case group (p = 0,0173). About QIQV, there was no difference among the average of final scores on the two groups. Neither correlation was encountered among EVA and QIQV on the case (rs= 0,29, p = 0,10) and control group (rs= 0,15, p = 0,38). It follows that the complaint of halitose among the individualsundergoing bariatric surgery isnt more frequent that in the group of obese individual waiting for bariatric surgery.
Assuntos
Humanos , Halitose , Obesidade , Qualidade de VidaAssuntos
Materiais Biocompatíveis , Polímeros , Tetraciclina , Compômeros , Materiais Dentários , Técnicas In VitroRESUMO
The aim of this work was study the effect of the chlorhexidine : hydroxypropyl-beta-cyclodextrin (CLX : HP-beta-CD) inclusion compound (IC) on in vitro slabs of bovine dentine. The substantivity, antimicrobial activity, and morphological effect of this inclusion compound were evaluated. Cyclodextrin improves the physical-chemical and pharmacological properties of drugs. Fragments of bovine dentine were immersed into either IC serial solutions at 0.24%, 0.12%, 0.06%, 0.03%, 0.015%, and 0.008% or controls water and free chlorhexidine. The desorption kinetics showed that CLX : HP-beta-CD compound release CLX for 6 days in a rate flow near to zero-order profile in comparison to plain CLX. Antimicrobial activity tests showed that CLX : HP-beta-CD inhibited A. actinomycetemcomitans and S. mutans significantly. The morphological effect studied by scanning electron microscopy (SEM) showed that CLX : HP-beta-CD did not cause morphological changes to the slab's surface. It is concluded that the chlorhexidine : hydroxypropyl-beta-CD inclusion compound creates an effective controlled release system with biological activity and that it may act as a good prevention and control agent of caries and periodontal disease in vivo.