RESUMO

We found increased age (p = 0.001) and history or evidence of stroke (p = 0.016) to be significant independent multivariate predictors of the presence and severity of leukoencephalopathy on magnetic resonance imaging brain scans in a mixed population of 35 elderly psychiatric patients and 25 neurologically healthy elderly volunteers. These results suggest that subcortical ischemia, as well as age-related changes that may not be vascular in origin, contribute to the emergence of periventricular and other deep white matter hyperintensities that are commonly seen on the magnetic resonance imaging brain scans of older adults.

Assuntos

Encéfalo/patologia , Leucoencefalopatia Multifocal Progressiva/patologia , Idoso , Análise de Variância , Isquemia Encefálica/patologia , Transtornos Cerebrovasculares/patologia , Diabetes Mellitus/patologia , Feminino , Humanos , Hipertensão/patologia , Ataque Isquêmico Transitório/patologia , Imageamento por Ressonância Magnética/métodos , Masculino , Análise de Regressão , Fatores de Risco