RESUMO

An 8-month-old boy with severe lactic acidosis was found to have lipoamide dehydrogenase deficiency. Treatment with thiamine, biotin, bicarbonate, protein restriction, and ketogenic diet failed to alleviate the lactic acidosis. Oral administration of lipoic acid 25 to 50 mg/kg produced dramatic improvement in lactic and pyruvic acidemia, which has continued for 2 years and which has been accompanied by clinical improvement.

Assuntos

Acidose/tratamento farmacológico , Di-Hidrolipoamida Desidrogenase/deficiência , Lactatos , Ácido Tióctico/uso terapêutico , Acidose/urina , Administração Oral , Di-Hidrolipoamida Desidrogenase/metabolismo , Fibroblastos/enzimologia , Humanos , Lactente , Complexo Cetoglutarato Desidrogenase/metabolismo , Masculino , Complexo Piruvato Desidrogenase/metabolismo , Pele/citologia